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Surface Modification of PHBV Fibrous Scaffold via Lithium Borohydride Reduction.

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Title: Surface Modification of PHBV Fibrous Scaffold via Lithium Borohydride Reduction.
Authors: Chaber, Paweł1 (AUTHOR) pchaber@cmpw-pan.pl, Tylko, Grzegorz2 (AUTHOR), Włodarczyk, Jakub1 (AUTHOR), Nitschke, Paweł1 (AUTHOR), Hercog, Anna1 (AUTHOR), Jurczyk, Sebastian3 (AUTHOR), Rech, Jakub4 (AUTHOR), Kubacki, Jerzy5 (AUTHOR), Adamus, Grażyna1 (AUTHOR) pchaber@cmpw-pan.pl
Source: Materials (1996-1944). Nov2022, Vol. 15 Issue 21, p7494. 20p.
Subjects: Lithium borohydride, Surface chemistry, Contact angle, Surface preparation, Cell morphology, Sodium borohydride
Abstract: In this study, lithium borohydride (LiBH4) reduction was used to modify the surface chemistry of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) fibers. Although the most common reaction employed in the surface treatment of polyester materials is hydrolysis, it is not suitable for fiber modification of bacterial polyesters, which are highly resistant to this type of reaction. The use of LiBH4 allowed the formation of surface hydroxyl groups under very mild conditions, which was crucial for maintaining the fibers' integrity. The presence of these groups resulted in a noticeable improvement in the surface hydrophilicity of PHBV, as revealed by contact angle measurements. After the treatment with a LiBH4 solution, the electrospun PHBV fibrous mat had a significantly greater number of viable osteoblast-like cells (SaOS-2 cell line) than the untreated mat. Moreover, the results of the cell proliferation measurements correlated well with the observed cell morphology. The most flattened SaOS-2 cells were found on the surface that supported the best cell attachment. Most importantly, the results of our study indicated that the degree of surface modification could be controlled by changing the degradation time and concentration of the borohydride solution. This was of great importance since it allowed optimization of the surface properties to achieve the highest cell-proliferation capacity. [ABSTRACT FROM AUTHOR]
Copyright of Materials (1996-1944) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Surface Modification of PHBV Fibrous Scaffold via Lithium Borohydride Reduction.
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  Data: <searchLink fieldCode="JN" term="%22Materials+%281996-1944%29%22">Materials (1996-1944)</searchLink>. Nov2022, Vol. 15 Issue 21, p7494. 20p.
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  Data: <searchLink fieldCode="DE" term="%22Lithium+borohydride%22">Lithium borohydride</searchLink><br /><searchLink fieldCode="DE" term="%22Surface+chemistry%22">Surface chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Contact+angle%22">Contact angle</searchLink><br /><searchLink fieldCode="DE" term="%22Surface+preparation%22">Surface preparation</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+morphology%22">Cell morphology</searchLink><br /><searchLink fieldCode="DE" term="%22Sodium+borohydride%22">Sodium borohydride</searchLink>
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  Data: In this study, lithium borohydride (LiBH4) reduction was used to modify the surface chemistry of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) fibers. Although the most common reaction employed in the surface treatment of polyester materials is hydrolysis, it is not suitable for fiber modification of bacterial polyesters, which are highly resistant to this type of reaction. The use of LiBH4 allowed the formation of surface hydroxyl groups under very mild conditions, which was crucial for maintaining the fibers' integrity. The presence of these groups resulted in a noticeable improvement in the surface hydrophilicity of PHBV, as revealed by contact angle measurements. After the treatment with a LiBH4 solution, the electrospun PHBV fibrous mat had a significantly greater number of viable osteoblast-like cells (SaOS-2 cell line) than the untreated mat. Moreover, the results of the cell proliferation measurements correlated well with the observed cell morphology. The most flattened SaOS-2 cells were found on the surface that supported the best cell attachment. Most importantly, the results of our study indicated that the degree of surface modification could be controlled by changing the degradation time and concentration of the borohydride solution. This was of great importance since it allowed optimization of the surface properties to achieve the highest cell-proliferation capacity. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Materials (1996-1944) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        StartPage: 7494
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      – SubjectFull: Lithium borohydride
        Type: general
      – SubjectFull: Surface chemistry
        Type: general
      – SubjectFull: Contact angle
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      – SubjectFull: Surface preparation
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      – SubjectFull: Cell morphology
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      – SubjectFull: Sodium borohydride
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      – TitleFull: Surface Modification of PHBV Fibrous Scaffold via Lithium Borohydride Reduction.
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              M: 11
              Text: Nov2022
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