The effect of zinc supplementation in children with attention deficit hyperactivity disorder: A systematic review and dose-response meta‑analysis of randomized clinical trials.
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| Title: | The effect of zinc supplementation in children with attention deficit hyperactivity disorder: A systematic review and dose-response meta‑analysis of randomized clinical trials. |
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| Authors: | Talebi, Sepide1 (AUTHOR), Miraghajani, Maryam2,3 (AUTHOR), Ghavami, Abed4 (AUTHOR), Mohammadi, Hamed1 (AUTHOR) |
| Source: | Critical Reviews in Food Science & Nutrition. 2022, Vol. 62 Issue 32, p9093-9102. 10p. |
| Abstract: | The present systematic review and dose-response meta-analysis was conducted to quantify the efficacy of zinc supplementation on clinical symptoms of attention-deficit/hyperactivity disorder (ADHD) in children. Electronic databases including PubMed, Scopus, ISI web of science, and Google Scholar were searched until January 2021. Results were reported as standardized mean difference (SMD) with a 95% confidence interval (CI) using Hedges's adjusted g method. six randomized clinical trials with 489 school-aged children were identified for the meta-analysis. Our findings showed a significant effect of zinc supplementation on ADHD total scores (SMD: −0.62 Hedges' g; 95% CI: −1.24 to −0.002, p = 0.04) but not in hyperactivity scores (SMD: −0.93 Hedges' g; 95% CI: −3.31 to 1.45, p = 0.44) and inattention scores (SMD: 0.21 Hedges' g; 95% CI: −0.09 to 0.51, p = 0.17) compared to the control group. Besides, the dose-response analysis did not find any significant non-linear association between zinc supplementation dosage or duration on ADHD total scores. The certainty of the evidence was rated moderate to very low for all outcomes. Zinc supplementation may have beneficial effects in improving ADHD symptoms in children with ADHD. Future well‐designed, large‐scale randomized controlled trials are needed to establish the benefit of zinc supplementation for ADHD. [ABSTRACT FROM AUTHOR] |
| Copyright of Critical Reviews in Food Science & Nutrition is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 160241275 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The effect of zinc supplementation in children with attention deficit hyperactivity disorder: A systematic review and dose-response meta‑analysis of randomized clinical trials. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Talebi%2C+Sepide%22">Talebi, Sepide</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Miraghajani%2C+Maryam%22">Miraghajani, Maryam</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ghavami%2C+Abed%22">Ghavami, Abed</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mohammadi%2C+Hamed%22">Mohammadi, Hamed</searchLink><relatesTo>1</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Critical+Reviews+in+Food+Science+%26+Nutrition%22">Critical Reviews in Food Science & Nutrition</searchLink>. 2022, Vol. 62 Issue 32, p9093-9102. 10p. – Name: Abstract Label: Abstract Group: Ab Data: The present systematic review and dose-response meta-analysis was conducted to quantify the efficacy of zinc supplementation on clinical symptoms of attention-deficit/hyperactivity disorder (ADHD) in children. Electronic databases including PubMed, Scopus, ISI web of science, and Google Scholar were searched until January 2021. Results were reported as standardized mean difference (SMD) with a 95% confidence interval (CI) using Hedges's adjusted g method. six randomized clinical trials with 489 school-aged children were identified for the meta-analysis. Our findings showed a significant effect of zinc supplementation on ADHD total scores (SMD: −0.62 Hedges' g; 95% CI: −1.24 to −0.002, p = 0.04) but not in hyperactivity scores (SMD: −0.93 Hedges' g; 95% CI: −3.31 to 1.45, p = 0.44) and inattention scores (SMD: 0.21 Hedges' g; 95% CI: −0.09 to 0.51, p = 0.17) compared to the control group. Besides, the dose-response analysis did not find any significant non-linear association between zinc supplementation dosage or duration on ADHD total scores. The certainty of the evidence was rated moderate to very low for all outcomes. Zinc supplementation may have beneficial effects in improving ADHD symptoms in children with ADHD. Future well‐designed, large‐scale randomized controlled trials are needed to establish the benefit of zinc supplementation for ADHD. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Critical Reviews in Food Science & Nutrition is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/10408398.2021.1940833 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 9093 Titles: – TitleFull: The effect of zinc supplementation in children with attention deficit hyperactivity disorder: A systematic review and dose-response meta‑analysis of randomized clinical trials. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Talebi, Sepide – PersonEntity: Name: NameFull: Miraghajani, Maryam – PersonEntity: Name: NameFull: Ghavami, Abed – PersonEntity: Name: NameFull: Mohammadi, Hamed IsPartOfRelationships: – BibEntity: Dates: – D: 18 M: 12 Text: 2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 10408398 Numbering: – Type: volume Value: 62 – Type: issue Value: 32 Titles: – TitleFull: Critical Reviews in Food Science & Nutrition Type: main |
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