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Economic potential of abbreviated breast MRI for screening women with dense breast tissue for breast cancer.

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Title: Economic potential of abbreviated breast MRI for screening women with dense breast tissue for breast cancer.
Authors: Tollens, Fabian1, Baltzer, Pascal A. T.2, Dietzel, Matthias3, Schnitzer, Moritz L.4, Schwarze, Vincent4, Kunz, Wolfgang G.4, Rink, Johann1, Rübenthaler, Johannes4, Froelich, Matthias F.1, Schönberg, Stefan O.1, Kaiser, Clemens G.1 clemens.kaiser@umm.de
Source: European Radiology. Nov2022, Vol. 32 Issue 11, p7409-7419. 11p. 1 Diagram, 3 Charts, 3 Graphs.
Subjects: Magnetic resonance imaging, Breast cancer, Cost effectiveness, Mammograms, Cancer chemotherapy
Abstract: Objectives: Abbreviated breast MRI (AB-MRI) was introduced to reduce both examination and image reading times and to improve cost-effectiveness of breast cancer screening. The aim of this model-based economic study was to analyze the cost-effectiveness of full protocol breast MRI (FB-MRI) vs. AB-MRI in screening women with dense breast tissue for breast cancer. Methods: Decision analysis and a Markov model were designed to model the cumulative costs and effects of biennial screening in terms of quality-adjusted life years (QALYs) from a US healthcare system perspective. Model input parameters for a cohort of women with dense breast tissue were adopted from recent literature. The impact of varying AB-MRI costs per examination as well as specificity on the resulting cost-effectiveness was modeled within deterministic sensitivity analyses. Results: At an assumed cost per examination of $ 263 for AB-MRI (84% of the cost of a FB-MRI examination), the discounted cumulative costs of both MR-based strategies accounted comparably. Reducing the costs of AB-MRI below $ 259 (82% of the cost of a FB-MRI examination, respectively), the incremental cost-effectiveness ratio of FB-MRI exceeded the willingness to pay threshold and the AB-MRI-strategy should be considered preferable in terms of cost-effectiveness. Conclusions: Our preliminary findings indicate that AB-MRI may be considered cost-effective compared to FB-MRI for screening women with dense breast tissue for breast cancer, as long as the costs per examination do not exceed 82% of the cost of a FB-MRI examination. Key Points: • Cost-effectiveness of abbreviated breast MRI is affected by reductions in specificity and resulting false positive findings and increased recall rates. • Abbreviated breast MRI may be cost-effective up to a cost per examination of 82% of the cost of a full protocol examination. • Abbreviated breast MRI could be an economically preferable alternative to full protocol breast MRI in screening women with dense breast tissue. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Economic potential of abbreviated breast MRI for screening women with dense breast tissue for breast cancer.
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  Data: <searchLink fieldCode="AR" term="%22Tollens%2C+Fabian%22">Tollens, Fabian</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Baltzer%2C+Pascal+A%2E+T%2E%22">Baltzer, Pascal A. T.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Dietzel%2C+Matthias%22">Dietzel, Matthias</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Schnitzer%2C+Moritz+L%2E%22">Schnitzer, Moritz L.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Schwarze%2C+Vincent%22">Schwarze, Vincent</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Kunz%2C+Wolfgang+G%2E%22">Kunz, Wolfgang G.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Rink%2C+Johann%22">Rink, Johann</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Rübenthaler%2C+Johannes%22">Rübenthaler, Johannes</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Froelich%2C+Matthias+F%2E%22">Froelich, Matthias F.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Schönberg%2C+Stefan+O%2E%22">Schönberg, Stefan O.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kaiser%2C+Clemens+G%2E%22">Kaiser, Clemens G.</searchLink><relatesTo>1</relatesTo><i> clemens.kaiser@umm.de</i>
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  Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Nov2022, Vol. 32 Issue 11, p7409-7419. 11p. 1 Diagram, 3 Charts, 3 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Breast+cancer%22">Breast cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Cost+effectiveness%22">Cost effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Mammograms%22">Mammograms</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+chemotherapy%22">Cancer chemotherapy</searchLink>
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  Data: Objectives: Abbreviated breast MRI (AB-MRI) was introduced to reduce both examination and image reading times and to improve cost-effectiveness of breast cancer screening. The aim of this model-based economic study was to analyze the cost-effectiveness of full protocol breast MRI (FB-MRI) vs. AB-MRI in screening women with dense breast tissue for breast cancer. Methods: Decision analysis and a Markov model were designed to model the cumulative costs and effects of biennial screening in terms of quality-adjusted life years (QALYs) from a US healthcare system perspective. Model input parameters for a cohort of women with dense breast tissue were adopted from recent literature. The impact of varying AB-MRI costs per examination as well as specificity on the resulting cost-effectiveness was modeled within deterministic sensitivity analyses. Results: At an assumed cost per examination of $ 263 for AB-MRI (84% of the cost of a FB-MRI examination), the discounted cumulative costs of both MR-based strategies accounted comparably. Reducing the costs of AB-MRI below $ 259 (82% of the cost of a FB-MRI examination, respectively), the incremental cost-effectiveness ratio of FB-MRI exceeded the willingness to pay threshold and the AB-MRI-strategy should be considered preferable in terms of cost-effectiveness. Conclusions: Our preliminary findings indicate that AB-MRI may be considered cost-effective compared to FB-MRI for screening women with dense breast tissue for breast cancer, as long as the costs per examination do not exceed 82% of the cost of a FB-MRI examination. Key Points: • Cost-effectiveness of abbreviated breast MRI is affected by reductions in specificity and resulting false positive findings and increased recall rates. • Abbreviated breast MRI may be cost-effective up to a cost per examination of 82% of the cost of a full protocol examination. • Abbreviated breast MRI could be an economically preferable alternative to full protocol breast MRI in screening women with dense breast tissue. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00330-022-08777-5
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