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Naringenin induces endoplasmic reticulum stress‐mediated cell apoptosis and autophagy in human oral squamous cell carcinoma cells.

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Title: Naringenin induces endoplasmic reticulum stress‐mediated cell apoptosis and autophagy in human oral squamous cell carcinoma cells.
Authors: Liu, Ju‐Fang1,2,3 (AUTHOR), Chang, Tsung‐Ming4 (AUTHOR), Chen, Po‐Han5 (AUTHOR), Lin, Jaster Szu‐Wei1 (AUTHOR), Tsai, Yih‐Jeng6,7 (AUTHOR), Wu, Hsing‐Mei6,7 (AUTHOR), Lee, Chia‐Jung6,7 (AUTHOR) gialon12@gmail.com
Source: Journal of Food Biochemistry. Nov2022, Vol. 46 Issue 11, p1-12. 12p.
Subjects: Cell death, Apoptosis, Squamous cell carcinoma, Endoplasmic reticulum, Autophagy, Naringenin, Betel nut, Reactive oxygen species
Abstract: Human oral squamous cell carcinoma (OSCC) has been one of the most common oral cancers owing to high percentage of betel nuts chewers, smokers, and alcohol consumption. With current treatment strategies in OSCC, more than half patients relapse and develop distant metastases with poor prognosis. To overcome the incident, OSCC poses a challenge in current therapies and treatments. Naringenin, a natural flavonoid, has been noted for antitumor effects on various types of cancers; however, the effects of naringenin on OSCC remain bias. In this study, naringenin demonstrated the potential multifunction in human OSCC cells not only leading to cell apoptosis, but also alternating the general function of autophagy, serving as pro‐survival mechanism by inducing the endoplasmic reticulum (ER) stress signaling through intracellular reactive oxygen species (ROS) production. In the process of programmed cell death, naringenin induced apoptotic signaling through caspase‐cascade, mitochondrial dysfunction, and ER stress by aberrance of Ca2+ release. In contrast, under the presence of naringenin, the pro‐survival has been altered into pro‐death to activate the caspases‐mediated apoptosis achieving cell death. The cross‐function of apoptosis and autophagy has demonstrated the effect of naringenin‐induced intracellular ROS activity in OSCC cells. Therefore, this study found that the effect of naringenin induces intracellular ROS to trigger programmed cell death and ER stress through the mechanisms of apoptosis and autophagy in human oral squamous carcinoma. Practical applications: This study revealed that naringenin debilitated the OSCC cell viability via the intracellular ROS production, ER stress, and autophagy, leading to cell apoptosis. Based on these studies and findings, naringenin provided an antitumor effect as a novel natural compound to improve the current therapies in OSCC. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Food Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
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  Data: Naringenin induces endoplasmic reticulum stress‐mediated cell apoptosis and autophagy in human oral squamous cell carcinoma cells.
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  Data: <searchLink fieldCode="AR" term="%22Liu%2C+Ju‐Fang%22">Liu, Ju‐Fang</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chang%2C+Tsung‐Ming%22">Chang, Tsung‐Ming</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Po‐Han%22">Chen, Po‐Han</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lin%2C+Jaster+Szu‐Wei%22">Lin, Jaster Szu‐Wei</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tsai%2C+Yih‐Jeng%22">Tsai, Yih‐Jeng</searchLink><relatesTo>6,7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wu%2C+Hsing‐Mei%22">Wu, Hsing‐Mei</searchLink><relatesTo>6,7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Chia‐Jung%22">Lee, Chia‐Jung</searchLink><relatesTo>6,7</relatesTo> (AUTHOR)<i> gialon12@gmail.com</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Food+Biochemistry%22">Journal of Food Biochemistry</searchLink>. Nov2022, Vol. 46 Issue 11, p1-12. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Cell+death%22">Cell death</searchLink><br /><searchLink fieldCode="DE" term="%22Apoptosis%22">Apoptosis</searchLink><br /><searchLink fieldCode="DE" term="%22Squamous+cell+carcinoma%22">Squamous cell carcinoma</searchLink><br /><searchLink fieldCode="DE" term="%22Endoplasmic+reticulum%22">Endoplasmic reticulum</searchLink><br /><searchLink fieldCode="DE" term="%22Autophagy%22">Autophagy</searchLink><br /><searchLink fieldCode="DE" term="%22Naringenin%22">Naringenin</searchLink><br /><searchLink fieldCode="DE" term="%22Betel+nut%22">Betel nut</searchLink><br /><searchLink fieldCode="DE" term="%22Reactive+oxygen+species%22">Reactive oxygen species</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Human oral squamous cell carcinoma (OSCC) has been one of the most common oral cancers owing to high percentage of betel nuts chewers, smokers, and alcohol consumption. With current treatment strategies in OSCC, more than half patients relapse and develop distant metastases with poor prognosis. To overcome the incident, OSCC poses a challenge in current therapies and treatments. Naringenin, a natural flavonoid, has been noted for antitumor effects on various types of cancers; however, the effects of naringenin on OSCC remain bias. In this study, naringenin demonstrated the potential multifunction in human OSCC cells not only leading to cell apoptosis, but also alternating the general function of autophagy, serving as pro‐survival mechanism by inducing the endoplasmic reticulum (ER) stress signaling through intracellular reactive oxygen species (ROS) production. In the process of programmed cell death, naringenin induced apoptotic signaling through caspase‐cascade, mitochondrial dysfunction, and ER stress by aberrance of Ca2+ release. In contrast, under the presence of naringenin, the pro‐survival has been altered into pro‐death to activate the caspases‐mediated apoptosis achieving cell death. The cross‐function of apoptosis and autophagy has demonstrated the effect of naringenin‐induced intracellular ROS activity in OSCC cells. Therefore, this study found that the effect of naringenin induces intracellular ROS to trigger programmed cell death and ER stress through the mechanisms of apoptosis and autophagy in human oral squamous carcinoma. Practical applications: This study revealed that naringenin debilitated the OSCC cell viability via the intracellular ROS production, ER stress, and autophagy, leading to cell apoptosis. Based on these studies and findings, naringenin provided an antitumor effect as a novel natural compound to improve the current therapies in OSCC. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Food Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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        Value: 10.1111/jfbc.14221
    Languages:
      – Code: eng
        Text: English
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      Pagination:
        PageCount: 12
        StartPage: 1
    Subjects:
      – SubjectFull: Cell death
        Type: general
      – SubjectFull: Apoptosis
        Type: general
      – SubjectFull: Squamous cell carcinoma
        Type: general
      – SubjectFull: Endoplasmic reticulum
        Type: general
      – SubjectFull: Autophagy
        Type: general
      – SubjectFull: Naringenin
        Type: general
      – SubjectFull: Betel nut
        Type: general
      – SubjectFull: Reactive oxygen species
        Type: general
    Titles:
      – TitleFull: Naringenin induces endoplasmic reticulum stress‐mediated cell apoptosis and autophagy in human oral squamous cell carcinoma cells.
        Type: main
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            NameFull: Liu, Ju‐Fang
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            NameFull: Chang, Tsung‐Ming
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            NameFull: Chen, Po‐Han
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            NameFull: Tsai, Yih‐Jeng
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            – D: 01
              M: 11
              Text: Nov2022
              Type: published
              Y: 2022
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