Cocoa presents cytotoxicity against melanoma cancer cell lines (A‐375 e B16‐F10) and improves chemotherapy activity by increasing oxidative stress.
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| Title: | Cocoa presents cytotoxicity against melanoma cancer cell lines (A‐375 e B16‐F10) and improves chemotherapy activity by increasing oxidative stress. |
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| Authors: | Mello, Gabriela Haas de1 (AUTHOR), D'Ávila, Camila Medianeira da Silva2 (AUTHOR), Viana, Altevir Rossato3 (AUTHOR), Krause, Luciana Maria Fontanari4 (AUTHOR), Cadoná, Francine Carla1 (AUTHOR) francinecadona@gmail.com |
| Source: | Journal of Food Biochemistry. Dec2022, Vol. 46 Issue 12, p1-12. 12p. |
| Subjects: | Oxidative stress, Cell lines, Cancer cells, Cocoa, Melanoma, Cell proliferation |
| Abstract: | Melanoma frequently presents a poor chemotherapy response. In this scenario, investigations for new therapies are essential. Thus, cocoa is highlighted in this area since it presents many biological properties. This study investigated the anticarcinogenic activity of cocoa in melanoma cell lines (A‐375 and B16‐F10). Melanoma and fibroblast (HFF‐1) cell lines were exposed to different concentrations of cocoa seeds (30 to 2000 ug/ml) at 24 and 72 h. Cocoa was also associated with paclitaxel IC50. We conducted viability, proliferation, and oxidative stress analyses. Our findings suggested that cocoa isolated, at almost all concentrations tested, was able to reduce viability and proliferation of B16‐F10 cells and proliferation of A‐375 cells via oxidative stress increasing. Also, cocoa caused no damage in fibroblast cells. Moreover, cocoa increased paclitaxel activity on A‐375 by reducing cell proliferation and increasing oxidative stress. Therefore, the results highlight cocoa as a potent selective adjuvant anticancer agent against melanoma. Practical applications: In conclusion, more studies should be performed to deeply explore this remarkable action of cocoa as a an promising adjuvant to enhance chemotherapy. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Food Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 161006745 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Cocoa presents cytotoxicity against melanoma cancer cell lines (A‐375 e B16‐F10) and improves chemotherapy activity by increasing oxidative stress. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Mello%2C+Gabriela+Haas+de%22">Mello, Gabriela Haas de</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22D'Ávila%2C+Camila+Medianeira+da+Silva%22">D'Ávila, Camila Medianeira da Silva</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Viana%2C+Altevir+Rossato%22">Viana, Altevir Rossato</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Krause%2C+Luciana+Maria+Fontanari%22">Krause, Luciana Maria Fontanari</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cadoná%2C+Francine+Carla%22">Cadoná, Francine Carla</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> francinecadona@gmail.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Food+Biochemistry%22">Journal of Food Biochemistry</searchLink>. Dec2022, Vol. 46 Issue 12, p1-12. 12p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Oxidative+stress%22">Oxidative stress</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+lines%22">Cell lines</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+cells%22">Cancer cells</searchLink><br /><searchLink fieldCode="DE" term="%22Cocoa%22">Cocoa</searchLink><br /><searchLink fieldCode="DE" term="%22Melanoma%22">Melanoma</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+proliferation%22">Cell proliferation</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Melanoma frequently presents a poor chemotherapy response. In this scenario, investigations for new therapies are essential. Thus, cocoa is highlighted in this area since it presents many biological properties. This study investigated the anticarcinogenic activity of cocoa in melanoma cell lines (A‐375 and B16‐F10). Melanoma and fibroblast (HFF‐1) cell lines were exposed to different concentrations of cocoa seeds (30 to 2000 ug/ml) at 24 and 72 h. Cocoa was also associated with paclitaxel IC50. We conducted viability, proliferation, and oxidative stress analyses. Our findings suggested that cocoa isolated, at almost all concentrations tested, was able to reduce viability and proliferation of B16‐F10 cells and proliferation of A‐375 cells via oxidative stress increasing. Also, cocoa caused no damage in fibroblast cells. Moreover, cocoa increased paclitaxel activity on A‐375 by reducing cell proliferation and increasing oxidative stress. Therefore, the results highlight cocoa as a potent selective adjuvant anticancer agent against melanoma. Practical applications: In conclusion, more studies should be performed to deeply explore this remarkable action of cocoa as a an promising adjuvant to enhance chemotherapy. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Food Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/jfbc.14512 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 1 Subjects: – SubjectFull: Oxidative stress Type: general – SubjectFull: Cell lines Type: general – SubjectFull: Cancer cells Type: general – SubjectFull: Cocoa Type: general – SubjectFull: Melanoma Type: general – SubjectFull: Cell proliferation Type: general Titles: – TitleFull: Cocoa presents cytotoxicity against melanoma cancer cell lines (A‐375 e B16‐F10) and improves chemotherapy activity by increasing oxidative stress. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Mello, Gabriela Haas de – PersonEntity: Name: NameFull: D'Ávila, Camila Medianeira da Silva – PersonEntity: Name: NameFull: Viana, Altevir Rossato – PersonEntity: Name: NameFull: Krause, Luciana Maria Fontanari – PersonEntity: Name: NameFull: Cadoná, Francine Carla IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 01458884 Numbering: – Type: volume Value: 46 – Type: issue Value: 12 Titles: – TitleFull: Journal of Food Biochemistry Type: main |
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