View in EDS HTML Full Text PDF Full Text

A Continuum-Tensegrity Computational Model for Chondrocyte Biomechanics in AFM Indentation and Micropipette Aspiration.

Saved in:
Bibliographic Details
Title: A Continuum-Tensegrity Computational Model for Chondrocyte Biomechanics in AFM Indentation and Micropipette Aspiration.
Authors: Arduino, Alessandro1 (AUTHOR), Pettenuzzo, Sofia1 (AUTHOR), Berardo, Alice1,2 (AUTHOR) alice.berardo@unipd.it, Salomoni, Valentina A.3 (AUTHOR), Majorana, Carmelo1 (AUTHOR), Carniel, Emanuele Luigi4 (AUTHOR)
Source: Annals of Biomedical Engineering. Dec2022, Vol. 50 Issue 12, p1911-1922. 12p.
Subjects: Cellular mechanics, Biomechanics, Atomic force microscopy, Morphogenesis, Mechanical models, Cartilage cells
Abstract: Mechanical stimuli are fundamental in the development of organs and tissues, their growth, regeneration or disease. They influence the biochemical signals produced by the cells, and, consequently, the development and spreading of a disease. Moreover, tumour cells are usually characterized by a decrease in the cell mechanical properties that may be directly linked to their metastatic potential. Thus, recently, the experimental and computational study of cell biomechanics is facing a growing interest. Various experimental approaches have been implemented to describe the passive response of cells; however, cell variability and complex experimental procedures may affect the obtained mechanical properties. For this reason, in-silico computational models have been developed through the years, to overcome such limitations, while proposing valuable tools to understand cell mechanical behaviour. This being the case, we propose a combined continuous-tensegrity finite element (FE) model to analyse the mechanical response of a cell and its subcomponents, observing how every part contributes to the overall mechanical behaviour. We modelled both Atomic Force Microscopy (AFM) indentation and micropipette aspiration techniques, as common mechanical tests for cells and elucidated also the role of cell cytoplasm and cytoskeleton in the global cell mechanical response. [ABSTRACT FROM AUTHOR]
Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: egs
DbLabel: Engineering Source
An: 161020048
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: A Continuum-Tensegrity Computational Model for Chondrocyte Biomechanics in AFM Indentation and Micropipette Aspiration.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Arduino%2C+Alessandro%22">Arduino, Alessandro</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pettenuzzo%2C+Sofia%22">Pettenuzzo, Sofia</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Berardo%2C+Alice%22">Berardo, Alice</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> alice.berardo@unipd.it</i><br /><searchLink fieldCode="AR" term="%22Salomoni%2C+Valentina+A%2E%22">Salomoni, Valentina A.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Majorana%2C+Carmelo%22">Majorana, Carmelo</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Carniel%2C+Emanuele+Luigi%22">Carniel, Emanuele Luigi</searchLink><relatesTo>4</relatesTo> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Annals+of+Biomedical+Engineering%22">Annals of Biomedical Engineering</searchLink>. Dec2022, Vol. 50 Issue 12, p1911-1922. 12p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Cellular+mechanics%22">Cellular mechanics</searchLink><br /><searchLink fieldCode="DE" term="%22Biomechanics%22">Biomechanics</searchLink><br /><searchLink fieldCode="DE" term="%22Atomic+force+microscopy%22">Atomic force microscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Morphogenesis%22">Morphogenesis</searchLink><br /><searchLink fieldCode="DE" term="%22Mechanical+models%22">Mechanical models</searchLink><br /><searchLink fieldCode="DE" term="%22Cartilage+cells%22">Cartilage cells</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Mechanical stimuli are fundamental in the development of organs and tissues, their growth, regeneration or disease. They influence the biochemical signals produced by the cells, and, consequently, the development and spreading of a disease. Moreover, tumour cells are usually characterized by a decrease in the cell mechanical properties that may be directly linked to their metastatic potential. Thus, recently, the experimental and computational study of cell biomechanics is facing a growing interest. Various experimental approaches have been implemented to describe the passive response of cells; however, cell variability and complex experimental procedures may affect the obtained mechanical properties. For this reason, in-silico computational models have been developed through the years, to overcome such limitations, while proposing valuable tools to understand cell mechanical behaviour. This being the case, we propose a combined continuous-tensegrity finite element (FE) model to analyse the mechanical response of a cell and its subcomponents, observing how every part contributes to the overall mechanical behaviour. We modelled both Atomic Force Microscopy (AFM) indentation and micropipette aspiration techniques, as common mechanical tests for cells and elucidated also the role of cell cytoplasm and cytoskeleton in the global cell mechanical response. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=161020048
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s10439-022-03011-1
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 12
        StartPage: 1911
    Subjects:
      – SubjectFull: Cellular mechanics
        Type: general
      – SubjectFull: Biomechanics
        Type: general
      – SubjectFull: Atomic force microscopy
        Type: general
      – SubjectFull: Morphogenesis
        Type: general
      – SubjectFull: Mechanical models
        Type: general
      – SubjectFull: Cartilage cells
        Type: general
    Titles:
      – TitleFull: A Continuum-Tensegrity Computational Model for Chondrocyte Biomechanics in AFM Indentation and Micropipette Aspiration.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Arduino, Alessandro
      – PersonEntity:
          Name:
            NameFull: Pettenuzzo, Sofia
      – PersonEntity:
          Name:
            NameFull: Berardo, Alice
      – PersonEntity:
          Name:
            NameFull: Salomoni, Valentina A.
      – PersonEntity:
          Name:
            NameFull: Majorana, Carmelo
      – PersonEntity:
          Name:
            NameFull: Carniel, Emanuele Luigi
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 12
              Text: Dec2022
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-print
              Value: 00906964
          Numbering:
            – Type: volume
              Value: 50
            – Type: issue
              Value: 12
          Titles:
            – TitleFull: Annals of Biomedical Engineering
              Type: main
ResultId 1