ROS- and pH-Responsive Polydopamine Functionalized Ti 3 C 2 T x MXene-Based Nanoparticles as Drug Delivery Nanocarriers with High Antibacterial Activity.
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| Title: | ROS- and pH-Responsive Polydopamine Functionalized Ti 3 C 2 T x MXene-Based Nanoparticles as Drug Delivery Nanocarriers with High Antibacterial Activity. |
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| Authors: | Zhang, Wei-Jin1 (AUTHOR), Li, Shuwei2 (AUTHOR), Vijayan, Veena3,4 (AUTHOR), Lee, Jun Seok1 (AUTHOR), Park, Sung Soo5 (AUTHOR), Cui, Xiuguo6 (AUTHOR), Chung, Ildoo1 (AUTHOR), Lee, Jaejun1 (AUTHOR), Ahn, Suk-kyun1 (AUTHOR), Kim, Jung Rae2 (AUTHOR), Park, In-Kyu3,4 (AUTHOR), Ha, Chang-Sik1 (AUTHOR) csha@pnu.edu |
| Source: | Nanomaterials (2079-4991). Dec2022, Vol. 12 Issue 24, p4392. 25p. |
| Subjects: | Nanocarriers, Photothermal effect, Antibacterial agents, Escherichia coli, Photothermal conversion, Drug delivery systems, Reactive oxygen species |
| Abstract: | Premature drug release and poor controllability is a challenge in the practical application of tumor therapy, which may lead to poor chemotherapy efficacy and severe adverse effects. In this study, a reactive oxygen species (ROS)-cleavable nanoparticle system (MXene-TK-DOX@PDA) was designed for effective chemotherapy drug delivery and antibacterial applications. Doxorubicin (DOX) was conjugated to the surface of (3-aminopropyl)triethoxysilane (APTES)-functionalized MXene via an ROS-cleavable diacetoxyl thioketal (TK) linkage. Subsequently, the surfaces of the MXene nanosheets were coated with pH-responsive polydopamine (PDA) as a gatekeeper. PDA endowed the MXene-TK-DOX@PDA nanoparticles with superior biocompatibility and stability. The MXene-TK-DOX@PDA nanoparticles had an ultrathin planar structure and a small lateral size of approximately 180 nm. The as-synthesized nanoparticles demonstrated outstanding photothermal conversion efficiency, superior photothermal stability, and a remarkable extinction coefficient (23.3 L g−1 cm−1 at 808 nm). DOX exhibited both efficient ROS-responsive and pH-responsive release performance from MXene-TK-DOX@PDA nanoparticles due to the cleavage of the thioketal linker. In addition, MXene-TK-DOX@PDA nanoparticles displayed high antibacterial activity against both Gram-negative Escherichia coli (E. coli) and Gram-positive Bacillus subtilis (B. subtilis) within 5 h. Taken together, we hope that MXene-TK-DOX@PDA nanoparticles will enrich the drug delivery system and significantly expand their applications in the biomedical field [ABSTRACT FROM AUTHOR] |
| Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Items | – Name: Title Label: Title Group: Ti Data: ROS- and pH-Responsive Polydopamine Functionalized Ti 3 C 2 T x MXene-Based Nanoparticles as Drug Delivery Nanocarriers with High Antibacterial Activity. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Zhang%2C+Wei-Jin%22">Zhang, Wei-Jin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Shuwei%22">Li, Shuwei</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vijayan%2C+Veena%22">Vijayan, Veena</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Jun+Seok%22">Lee, Jun Seok</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Park%2C+Sung+Soo%22">Park, Sung Soo</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cui%2C+Xiuguo%22">Cui, Xiuguo</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chung%2C+Ildoo%22">Chung, Ildoo</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Jaejun%22">Lee, Jaejun</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ahn%2C+Suk-kyun%22">Ahn, Suk-kyun</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Jung+Rae%22">Kim, Jung Rae</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Park%2C+In-Kyu%22">Park, In-Kyu</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ha%2C+Chang-Sik%22">Ha, Chang-Sik</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> csha@pnu.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. Dec2022, Vol. 12 Issue 24, p4392. 25p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Nanocarriers%22">Nanocarriers</searchLink><br /><searchLink fieldCode="DE" term="%22Photothermal+effect%22">Photothermal effect</searchLink><br /><searchLink fieldCode="DE" term="%22Antibacterial+agents%22">Antibacterial agents</searchLink><br /><searchLink fieldCode="DE" term="%22Escherichia+coli%22">Escherichia coli</searchLink><br /><searchLink fieldCode="DE" term="%22Photothermal+conversion%22">Photothermal conversion</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+delivery+systems%22">Drug delivery systems</searchLink><br /><searchLink fieldCode="DE" term="%22Reactive+oxygen+species%22">Reactive oxygen species</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Premature drug release and poor controllability is a challenge in the practical application of tumor therapy, which may lead to poor chemotherapy efficacy and severe adverse effects. In this study, a reactive oxygen species (ROS)-cleavable nanoparticle system (MXene-TK-DOX@PDA) was designed for effective chemotherapy drug delivery and antibacterial applications. Doxorubicin (DOX) was conjugated to the surface of (3-aminopropyl)triethoxysilane (APTES)-functionalized MXene via an ROS-cleavable diacetoxyl thioketal (TK) linkage. Subsequently, the surfaces of the MXene nanosheets were coated with pH-responsive polydopamine (PDA) as a gatekeeper. PDA endowed the MXene-TK-DOX@PDA nanoparticles with superior biocompatibility and stability. The MXene-TK-DOX@PDA nanoparticles had an ultrathin planar structure and a small lateral size of approximately 180 nm. The as-synthesized nanoparticles demonstrated outstanding photothermal conversion efficiency, superior photothermal stability, and a remarkable extinction coefficient (23.3 L g−1 cm−1 at 808 nm). DOX exhibited both efficient ROS-responsive and pH-responsive release performance from MXene-TK-DOX@PDA nanoparticles due to the cleavage of the thioketal linker. In addition, MXene-TK-DOX@PDA nanoparticles displayed high antibacterial activity against both Gram-negative Escherichia coli (E. coli) and Gram-positive Bacillus subtilis (B. subtilis) within 5 h. Taken together, we hope that MXene-TK-DOX@PDA nanoparticles will enrich the drug delivery system and significantly expand their applications in the biomedical field [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/nano12244392 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 25 StartPage: 4392 Subjects: – SubjectFull: Nanocarriers Type: general – SubjectFull: Photothermal effect Type: general – SubjectFull: Antibacterial agents Type: general – SubjectFull: Escherichia coli Type: general – SubjectFull: Photothermal conversion Type: general – SubjectFull: Drug delivery systems Type: general – SubjectFull: Reactive oxygen species Type: general Titles: – TitleFull: ROS- and pH-Responsive Polydopamine Functionalized Ti 3 C 2 T x MXene-Based Nanoparticles as Drug Delivery Nanocarriers with High Antibacterial Activity. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Zhang, Wei-Jin – PersonEntity: Name: NameFull: Li, Shuwei – PersonEntity: Name: NameFull: Vijayan, Veena – PersonEntity: Name: NameFull: Lee, Jun Seok – PersonEntity: Name: NameFull: Park, Sung Soo – PersonEntity: Name: NameFull: Cui, Xiuguo – PersonEntity: Name: NameFull: Chung, Ildoo – PersonEntity: Name: NameFull: Lee, Jaejun – PersonEntity: Name: NameFull: Ahn, Suk-kyun – PersonEntity: Name: NameFull: Kim, Jung Rae – PersonEntity: Name: NameFull: Park, In-Kyu – PersonEntity: Name: NameFull: Ha, Chang-Sik IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 12 Text: Dec2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 20794991 Numbering: – Type: volume Value: 12 – Type: issue Value: 24 Titles: – TitleFull: Nanomaterials (2079-4991) Type: main |
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