ROS- and pH-Responsive Polydopamine Functionalized Ti 3 C 2 T x MXene-Based Nanoparticles as Drug Delivery Nanocarriers with High Antibacterial Activity.
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| Title: | ROS- and pH-Responsive Polydopamine Functionalized Ti 3 C 2 T x MXene-Based Nanoparticles as Drug Delivery Nanocarriers with High Antibacterial Activity. |
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| Authors: | Zhang, Wei-Jin1 (AUTHOR), Li, Shuwei2 (AUTHOR), Vijayan, Veena3,4 (AUTHOR), Lee, Jun Seok1 (AUTHOR), Park, Sung Soo5 (AUTHOR), Cui, Xiuguo6 (AUTHOR), Chung, Ildoo1 (AUTHOR), Lee, Jaejun1 (AUTHOR), Ahn, Suk-kyun1 (AUTHOR), Kim, Jung Rae2 (AUTHOR), Park, In-Kyu3,4 (AUTHOR), Ha, Chang-Sik1 (AUTHOR) csha@pnu.edu |
| Source: | Nanomaterials (2079-4991). Dec2022, Vol. 12 Issue 24, p4392. 25p. |
| Subjects: | Nanocarriers, Photothermal effect, Antibacterial agents, Escherichia coli, Photothermal conversion, Drug delivery systems, Reactive oxygen species |
| Abstract: | Premature drug release and poor controllability is a challenge in the practical application of tumor therapy, which may lead to poor chemotherapy efficacy and severe adverse effects. In this study, a reactive oxygen species (ROS)-cleavable nanoparticle system (MXene-TK-DOX@PDA) was designed for effective chemotherapy drug delivery and antibacterial applications. Doxorubicin (DOX) was conjugated to the surface of (3-aminopropyl)triethoxysilane (APTES)-functionalized MXene via an ROS-cleavable diacetoxyl thioketal (TK) linkage. Subsequently, the surfaces of the MXene nanosheets were coated with pH-responsive polydopamine (PDA) as a gatekeeper. PDA endowed the MXene-TK-DOX@PDA nanoparticles with superior biocompatibility and stability. The MXene-TK-DOX@PDA nanoparticles had an ultrathin planar structure and a small lateral size of approximately 180 nm. The as-synthesized nanoparticles demonstrated outstanding photothermal conversion efficiency, superior photothermal stability, and a remarkable extinction coefficient (23.3 L g−1 cm−1 at 808 nm). DOX exhibited both efficient ROS-responsive and pH-responsive release performance from MXene-TK-DOX@PDA nanoparticles due to the cleavage of the thioketal linker. In addition, MXene-TK-DOX@PDA nanoparticles displayed high antibacterial activity against both Gram-negative Escherichia coli (E. coli) and Gram-positive Bacillus subtilis (B. subtilis) within 5 h. Taken together, we hope that MXene-TK-DOX@PDA nanoparticles will enrich the drug delivery system and significantly expand their applications in the biomedical field [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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