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Structural analysis of DNA molecule in a confined shell.

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Title: Structural analysis of DNA molecule in a confined shell.
Authors: Maity, Arghya1,2 (AUTHOR), Mathur, Neha1 (AUTHOR), Imhof, Petra3 (AUTHOR), Singh, Navin1 (AUTHOR) navin@pilani.bits-pilani.ac.in
Source: Physica A. Jan2023, Vol. 609, pN.PAG-N.PAG. 1p.
Subjects: DNA analysis, Molecular dynamics, DNA structure, Molecules, Gene therapy
Abstract: Recent advances in operating and manipulating DNA have provided unique experimental possibilities in many fields of DNA research, especially in gene therapy. Researchers have deployed many techniques, experimental and theoretical, to study the DNA structure changes due to external perturbation. It is crucial to understand the structural and dynamical changes in the DNA molecules in a confined state to understand and control the self-assembly of DNA confined in a chamber or nano-channel for various applications. In the current manuscript, we extend the work study the effect of confinement on the thermal stability and the structural properties of duplex DNA. The present work is an extension of our previous research works (Maity et al., 2019; 2020). For our study we have considered a 1 BNA chain that is confined in a cylindrical geometry. How the geometry of the confinement affects the opening and other structural parameters of DNA molecule is the objective of this manuscript. We have used a statistical model(PBD model) and Molecular dynamics simulations for our purpose. [ABSTRACT FROM AUTHOR]
Copyright of Physica A is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 161059171
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Structural analysis of DNA molecule in a confined shell.
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  Data: <searchLink fieldCode="DE" term="%22DNA+analysis%22">DNA analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+dynamics%22">Molecular dynamics</searchLink><br /><searchLink fieldCode="DE" term="%22DNA+structure%22">DNA structure</searchLink><br /><searchLink fieldCode="DE" term="%22Molecules%22">Molecules</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+therapy%22">Gene therapy</searchLink>
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  Label: Abstract
  Group: Ab
  Data: Recent advances in operating and manipulating DNA have provided unique experimental possibilities in many fields of DNA research, especially in gene therapy. Researchers have deployed many techniques, experimental and theoretical, to study the DNA structure changes due to external perturbation. It is crucial to understand the structural and dynamical changes in the DNA molecules in a confined state to understand and control the self-assembly of DNA confined in a chamber or nano-channel for various applications. In the current manuscript, we extend the work study the effect of confinement on the thermal stability and the structural properties of duplex DNA. The present work is an extension of our previous research works (Maity et al., 2019; 2020). For our study we have considered a 1 BNA chain that is confined in a cylindrical geometry. How the geometry of the confinement affects the opening and other structural parameters of DNA molecule is the objective of this manuscript. We have used a statistical model(PBD model) and Molecular dynamics simulations for our purpose. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Physica A is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.physa.2022.128382
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      – Code: eng
        Text: English
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      – SubjectFull: DNA analysis
        Type: general
      – SubjectFull: Molecular dynamics
        Type: general
      – SubjectFull: DNA structure
        Type: general
      – SubjectFull: Molecules
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      – SubjectFull: Gene therapy
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      – TitleFull: Structural analysis of DNA molecule in a confined shell.
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            – D: 01
              M: 01
              Text: Jan2023
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              Y: 2023
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