View in EDS

Colonic budesonide delivery by multistimuli alginate/Eudragit® FS 30D/inulin-based microspheres as a paediatric formulation.

Saved in:
Bibliographic Details
Title: Colonic budesonide delivery by multistimuli alginate/Eudragit® FS 30D/inulin-based microspheres as a paediatric formulation.
Authors: D'Amico, Vita1 (AUTHOR), Arduino, Ilaria1 (AUTHOR), Vacca, Mirco2 (AUTHOR), Iacobazzi, Rosa Maria1 (AUTHOR), Altamura, Davide3 (AUTHOR), Lopalco, Antonio1 (AUTHOR), Rizzi, Rosanna3 (AUTHOR), Cutrignelli, Annalisa1 (AUTHOR), Laquintana, Valentino1 (AUTHOR), Massimo, Franco1 (AUTHOR), De Angelis, Maria2 (AUTHOR), Denora, Nunzio1 (AUTHOR) nunzio.denora@uniba.it, Lopedota, Angela Assunta1 (AUTHOR) angelaassunta.lopedota@uniba.it
Source: Carbohydrate Polymers. Feb2023, Vol. 302, pN.PAG-N.PAG. 1p.
Subjects: Alginates, Microspheres, Oral drug administration, Inflammatory bowel diseases, Inulin, Budesonide, Drug delivery systems
Abstract: The purpose of this study was to develop an oral paediatric formulation of budesonide (BUD) for the treatment of inflammatory bowel disease. A formulation realized as microspheres using the prilling/vibration technique is proposed as an innovative drug delivery system ensuring BUD-specific colonic release in response to different triggers, such as pH, transit time, and resident microbiota. BUD, or the inclusion complex BUD/hydroxypropyl-β-cyclodextrin, was loaded into microspheres consisting of different ratios of alginate, Eudragit® FS 30D, with or without inulin. Sixteen formulations are produced that show high yields and encapsulation efficiencies, ensuring a homogenous distribution of BUD into the matrix. Microsphere diameters of <655 μm and promising flow properties make these systems suitable for oral administration to children. Swelling and drug release studies in simulated gastrointestinal fluid are used to demonstrate the response of microspheres to time and pH triggers. Studies in faecal medium highlight that drug release from microspheres with inulin is also influenced by microbiota. [ABSTRACT FROM AUTHOR]
Copyright of Carbohydrate Polymers is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 161120841
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Colonic budesonide delivery by multistimuli alginate/Eudragit&#174; FS 30D/inulin-based microspheres as a paediatric formulation.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22D&#39;Amico%2C+Vita%22&quot;&gt;D&#39;Amico, Vita&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Arduino%2C+Ilaria%22&quot;&gt;Arduino, Ilaria&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Vacca%2C+Mirco%22&quot;&gt;Vacca, Mirco&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Iacobazzi%2C+Rosa+Maria%22&quot;&gt;Iacobazzi, Rosa Maria&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Altamura%2C+Davide%22&quot;&gt;Altamura, Davide&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lopalco%2C+Antonio%22&quot;&gt;Lopalco, Antonio&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rizzi%2C+Rosanna%22&quot;&gt;Rizzi, Rosanna&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cutrignelli%2C+Annalisa%22&quot;&gt;Cutrignelli, Annalisa&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Laquintana%2C+Valentino%22&quot;&gt;Laquintana, Valentino&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Massimo%2C+Franco%22&quot;&gt;Massimo, Franco&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22De+Angelis%2C+Maria%22&quot;&gt;De Angelis, Maria&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Denora%2C+Nunzio%22&quot;&gt;Denora, Nunzio&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; nunzio.denora@uniba.it&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lopedota%2C+Angela+Assunta%22&quot;&gt;Lopedota, Angela Assunta&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; angelaassunta.lopedota@uniba.it&lt;/i&gt;
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Carbohydrate+Polymers%22&quot;&gt;Carbohydrate Polymers&lt;/searchLink&gt;. Feb2023, Vol. 302, pN.PAG-N.PAG. 1p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Alginates%22&quot;&gt;Alginates&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Microspheres%22&quot;&gt;Microspheres&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Oral+drug+administration%22&quot;&gt;Oral drug administration&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Inflammatory+bowel+diseases%22&quot;&gt;Inflammatory bowel diseases&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Inulin%22&quot;&gt;Inulin&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Budesonide%22&quot;&gt;Budesonide&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Drug+delivery+systems%22&quot;&gt;Drug delivery systems&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The purpose of this study was to develop an oral paediatric formulation of budesonide (BUD) for the treatment of inflammatory bowel disease. A formulation realized as microspheres using the prilling/vibration technique is proposed as an innovative drug delivery system ensuring BUD-specific colonic release in response to different triggers, such as pH, transit time, and resident microbiota. BUD, or the inclusion complex BUD/hydroxypropyl-β-cyclodextrin, was loaded into microspheres consisting of different ratios of alginate, Eudragit&#174; FS 30D, with or without inulin. Sixteen formulations are produced that show high yields and encapsulation efficiencies, ensuring a homogenous distribution of BUD into the matrix. Microsphere diameters of &lt;655 μm and promising flow properties make these systems suitable for oral administration to children. Swelling and drug release studies in simulated gastrointestinal fluid are used to demonstrate the response of microspheres to time and pH triggers. Studies in faecal medium highlight that drug release from microspheres with inulin is also influenced by microbiota. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Carbohydrate Polymers is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=161120841
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.carbpol.2022.120422
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Alginates
        Type: general
      – SubjectFull: Microspheres
        Type: general
      – SubjectFull: Oral drug administration
        Type: general
      – SubjectFull: Inflammatory bowel diseases
        Type: general
      – SubjectFull: Inulin
        Type: general
      – SubjectFull: Budesonide
        Type: general
      – SubjectFull: Drug delivery systems
        Type: general
    Titles:
      – TitleFull: Colonic budesonide delivery by multistimuli alginate/Eudragit® FS 30D/inulin-based microspheres as a paediatric formulation.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: D'Amico, Vita
      – PersonEntity:
          Name:
            NameFull: Arduino, Ilaria
      – PersonEntity:
          Name:
            NameFull: Vacca, Mirco
      – PersonEntity:
          Name:
            NameFull: Iacobazzi, Rosa Maria
      – PersonEntity:
          Name:
            NameFull: Altamura, Davide
      – PersonEntity:
          Name:
            NameFull: Lopalco, Antonio
      – PersonEntity:
          Name:
            NameFull: Rizzi, Rosanna
      – PersonEntity:
          Name:
            NameFull: Cutrignelli, Annalisa
      – PersonEntity:
          Name:
            NameFull: Laquintana, Valentino
      – PersonEntity:
          Name:
            NameFull: Massimo, Franco
      – PersonEntity:
          Name:
            NameFull: De Angelis, Maria
      – PersonEntity:
          Name:
            NameFull: Denora, Nunzio
      – PersonEntity:
          Name:
            NameFull: Lopedota, Angela Assunta
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 15
              M: 02
              Text: Feb2023
              Type: published
              Y: 2023
          Identifiers:
            – Type: issn-print
              Value: 01448617
          Numbering:
            – Type: volume
              Value: 302
          Titles:
            – TitleFull: Carbohydrate Polymers
              Type: main
ResultId 1