Characterization of eutectic mixtures of sugars and sugar-alcohols for cryopreservation.
Saved in:
| Title: | Characterization of eutectic mixtures of sugars and sugar-alcohols for cryopreservation. |
|---|---|
| Authors: | Joules, Adam1 (AUTHOR) juelf002@umn.edu, Burrows, Tessa1 (AUTHOR) burro139@umn.edu, I. Dosa, Peter1,2 (AUTHOR) pidosa@umn.edu, Hubel, Allison1,3 (AUTHOR) |
| Source: | Journal of Molecular Liquids. Feb2023, Vol. 371, pN.PAG-N.PAG. 1p. |
| Subjects: | Molecular volume, Hydrogen bonding interactions, Eutectic reactions, Latent heat of fusion, Mixtures, Sugar content of food |
| Abstract: | • NADES non-NADES were characterized by viscosity, density, DSC, water activity, and Raman across dilution. • Molar and excess volumes revealed NADES have as strong intermolecular bonding as glyceline. • Greatest excess volumes were in the water rich region. • Water activity of NADES is lower than non-NADES mixtures. • Raman cryomicroscopy revealed stronger hydrogen bonding for NADES. Natural Deep Eutectic Systems (NADES) composed of sugar and sugar alcohols have been studied and applied in a variety of biological applications. Understanding their interaction with water across dilution and temperature is inherently important for maximizing the utility of NADES. Herein a wide range of sugar:sugar-alcohol molar ratios were synthesized and characterized by viscosity, molar excess volume, differential scanning calorimetry, water activity, and confocal Raman cryomicroscopy. NADES were found to have greater viscosity, reduced heat of fusion, greater absolute molar excess volume, lower water activity, and stronger hydrogen bonding of water than non-NADES mixtures. This is hypothesized to be due to cumulatively stronger hydrogen bonding interactions between components in pure and diluted NADES with the strongest interactions in the water-rich region. This work provides useful data and further understanding of hydrogen bonding interaction strength for a wide range of molar ratios in pure to well-diluted forms. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Molecular Liquids is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: egs DbLabel: Engineering Source An: 161277953 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Characterization of eutectic mixtures of sugars and sugar-alcohols for cryopreservation. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Joules%2C+Adam%22">Joules, Adam</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> juelf002@umn.edu</i><br /><searchLink fieldCode="AR" term="%22Burrows%2C+Tessa%22">Burrows, Tessa</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> burro139@umn.edu</i><br /><searchLink fieldCode="AR" term="%22I%2E+Dosa%2C+Peter%22">I. Dosa, Peter</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> pidosa@umn.edu</i><br /><searchLink fieldCode="AR" term="%22Hubel%2C+Allison%22">Hubel, Allison</searchLink><relatesTo>1,3</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Molecular+Liquids%22">Journal of Molecular Liquids</searchLink>. Feb2023, Vol. 371, pN.PAG-N.PAG. 1p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Molecular+volume%22">Molecular volume</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrogen+bonding+interactions%22">Hydrogen bonding interactions</searchLink><br /><searchLink fieldCode="DE" term="%22Eutectic+reactions%22">Eutectic reactions</searchLink><br /><searchLink fieldCode="DE" term="%22Latent+heat+of+fusion%22">Latent heat of fusion</searchLink><br /><searchLink fieldCode="DE" term="%22Mixtures%22">Mixtures</searchLink><br /><searchLink fieldCode="DE" term="%22Sugar+content+of+food%22">Sugar content of food</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: • NADES non-NADES were characterized by viscosity, density, DSC, water activity, and Raman across dilution. • Molar and excess volumes revealed NADES have as strong intermolecular bonding as glyceline. • Greatest excess volumes were in the water rich region. • Water activity of NADES is lower than non-NADES mixtures. • Raman cryomicroscopy revealed stronger hydrogen bonding for NADES. Natural Deep Eutectic Systems (NADES) composed of sugar and sugar alcohols have been studied and applied in a variety of biological applications. Understanding their interaction with water across dilution and temperature is inherently important for maximizing the utility of NADES. Herein a wide range of sugar:sugar-alcohol molar ratios were synthesized and characterized by viscosity, molar excess volume, differential scanning calorimetry, water activity, and confocal Raman cryomicroscopy. NADES were found to have greater viscosity, reduced heat of fusion, greater absolute molar excess volume, lower water activity, and stronger hydrogen bonding of water than non-NADES mixtures. This is hypothesized to be due to cumulatively stronger hydrogen bonding interactions between components in pure and diluted NADES with the strongest interactions in the water-rich region. This work provides useful data and further understanding of hydrogen bonding interaction strength for a wide range of molar ratios in pure to well-diluted forms. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Molecular Liquids is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=161277953 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.molliq.2022.120937 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: N.PAG Subjects: – SubjectFull: Molecular volume Type: general – SubjectFull: Hydrogen bonding interactions Type: general – SubjectFull: Eutectic reactions Type: general – SubjectFull: Latent heat of fusion Type: general – SubjectFull: Mixtures Type: general – SubjectFull: Sugar content of food Type: general Titles: – TitleFull: Characterization of eutectic mixtures of sugars and sugar-alcohols for cryopreservation. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Joules, Adam – PersonEntity: Name: NameFull: Burrows, Tessa – PersonEntity: Name: NameFull: I. Dosa, Peter – PersonEntity: Name: NameFull: Hubel, Allison IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 01677322 Numbering: – Type: volume Value: 371 Titles: – TitleFull: Journal of Molecular Liquids Type: main |
| ResultId | 1 |
