Characterization of eutectic mixtures of sugars and sugar-alcohols for cryopreservation.
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| Title: | Characterization of eutectic mixtures of sugars and sugar-alcohols for cryopreservation. |
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| Authors: | Joules, Adam1 (AUTHOR) juelf002@umn.edu, Burrows, Tessa1 (AUTHOR) burro139@umn.edu, I. Dosa, Peter1,2 (AUTHOR) pidosa@umn.edu, Hubel, Allison1,3 (AUTHOR) |
| Source: | Journal of Molecular Liquids. Feb2023, Vol. 371, pN.PAG-N.PAG. 1p. |
| Subjects: | Molecular volume, Hydrogen bonding interactions, Eutectic reactions, Latent heat of fusion, Mixtures, Sugar content of food |
| Abstract: | • NADES non-NADES were characterized by viscosity, density, DSC, water activity, and Raman across dilution. • Molar and excess volumes revealed NADES have as strong intermolecular bonding as glyceline. • Greatest excess volumes were in the water rich region. • Water activity of NADES is lower than non-NADES mixtures. • Raman cryomicroscopy revealed stronger hydrogen bonding for NADES. Natural Deep Eutectic Systems (NADES) composed of sugar and sugar alcohols have been studied and applied in a variety of biological applications. Understanding their interaction with water across dilution and temperature is inherently important for maximizing the utility of NADES. Herein a wide range of sugar:sugar-alcohol molar ratios were synthesized and characterized by viscosity, molar excess volume, differential scanning calorimetry, water activity, and confocal Raman cryomicroscopy. NADES were found to have greater viscosity, reduced heat of fusion, greater absolute molar excess volume, lower water activity, and stronger hydrogen bonding of water than non-NADES mixtures. This is hypothesized to be due to cumulatively stronger hydrogen bonding interactions between components in pure and diluted NADES with the strongest interactions in the water-rich region. This work provides useful data and further understanding of hydrogen bonding interaction strength for a wide range of molar ratios in pure to well-diluted forms. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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