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Radio‐luminescent imaging for rapid, high‐resolution eye plaque loading verification.

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Title: Radio‐luminescent imaging for rapid, high‐resolution eye plaque loading verification.
Authors: Yan, Huagang1 (AUTHOR), De Jean, Paul2 (AUTHOR), Grafil, Elliot2 (AUTHOR), Ashraf, Ramish3 (AUTHOR), Niedermayr, Thomas3 (AUTHOR), Astrahan, Melvin4 (AUTHOR), Mruthyunjaya, Prithvi5 (AUTHOR), Beadle, Beth3 (AUTHOR), Xing, Lei3 (AUTHOR), Liu, Wu3 (AUTHOR) wuliu@stanford.edu
Source: Medical Physics. Jan2023, Vol. 50 Issue 1, p142-151. 10p.
Subjects: Radioisotope brachytherapy, Monte Carlo method, Imaging phantoms, Scintillators
Abstract: Background: Eye plaque brachytherapy is currently an optimal therapy for intraocular cancers. Due to the lack of an effective and practical technique to measure the seed radioactivity distribution, current quality assurance (QA) practice according to the American Association of Physicists in Medicine TG129 only stipulates that the plaque assembly be visually inspected. Consequently, uniform seed activity is routinely adopted to avoid possible loading mistakes of differential seed loading. However, modulated dose delivery, which represents a general trend in radiotherapy to provide more personalized treatment for a given tumor and patient, requires differential activities in the loaded seeds. Purpose: In this study, a fast and low‐cost radio‐luminescent imaging and dose calculating system to verify the seed activity distribution for differential loading was developed. Methods: A proof‐of‐concept system consisting of a thin scintillator sheet coupled to a camera/lens system was constructed. A seed‐loaded plaque can be placed directly on the scintillator surface with the radioactive seeds facing the scintillator. The camera system collects the radioluminescent signal generated by the scintillator on its opposite side. The predicted dose distribution in the scintillator's sensitive layer was calculated using a Monte Carlo simulation with the planned plaque loading pattern of I‐125 seeds. Quantitative comparisons of the distribution of relative measured signal intensity and that of the relative predicted dose in the sensitive layer were performed by gamma analysis, similar to intensity‐modulated radiation therapy QA. Results: Data analyses showed high gamma (3%/0.3 mm, global, 20% threshold) passing rates for correct seed loadings and low passing rates with distinguished high gamma value area for incorrect loadings, indicating that possible errors may be detected. The measurement and analysis only required a few extra minutes, significantly shorter than the time to assay the extra verification seeds the physicist already must perform as recommended by TG129. Conclusions: Radio‐luminescent QA can be used to facilitate and assure the implementation of intensity‐modulated, customized plaque loading. [ABSTRACT FROM AUTHOR]
Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Radio‐luminescent imaging for rapid, high‐resolution eye plaque loading verification.
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  Data: <searchLink fieldCode="AR" term="%22Yan%2C+Huagang%22">Yan, Huagang</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22De+Jean%2C+Paul%22">De Jean, Paul</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Grafil%2C+Elliot%22">Grafil, Elliot</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ashraf%2C+Ramish%22">Ashraf, Ramish</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Niedermayr%2C+Thomas%22">Niedermayr, Thomas</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Astrahan%2C+Melvin%22">Astrahan, Melvin</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mruthyunjaya%2C+Prithvi%22">Mruthyunjaya, Prithvi</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Beadle%2C+Beth%22">Beadle, Beth</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xing%2C+Lei%22">Xing, Lei</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Wu%22">Liu, Wu</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> wuliu@stanford.edu</i>
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  Data: <searchLink fieldCode="JN" term="%22Medical+Physics%22">Medical Physics</searchLink>. Jan2023, Vol. 50 Issue 1, p142-151. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Radioisotope+brachytherapy%22">Radioisotope brachytherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Monte+Carlo+method%22">Monte Carlo method</searchLink><br /><searchLink fieldCode="DE" term="%22Imaging+phantoms%22">Imaging phantoms</searchLink><br /><searchLink fieldCode="DE" term="%22Scintillators%22">Scintillators</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Background: Eye plaque brachytherapy is currently an optimal therapy for intraocular cancers. Due to the lack of an effective and practical technique to measure the seed radioactivity distribution, current quality assurance (QA) practice according to the American Association of Physicists in Medicine TG129 only stipulates that the plaque assembly be visually inspected. Consequently, uniform seed activity is routinely adopted to avoid possible loading mistakes of differential seed loading. However, modulated dose delivery, which represents a general trend in radiotherapy to provide more personalized treatment for a given tumor and patient, requires differential activities in the loaded seeds. Purpose: In this study, a fast and low‐cost radio‐luminescent imaging and dose calculating system to verify the seed activity distribution for differential loading was developed. Methods: A proof‐of‐concept system consisting of a thin scintillator sheet coupled to a camera/lens system was constructed. A seed‐loaded plaque can be placed directly on the scintillator surface with the radioactive seeds facing the scintillator. The camera system collects the radioluminescent signal generated by the scintillator on its opposite side. The predicted dose distribution in the scintillator's sensitive layer was calculated using a Monte Carlo simulation with the planned plaque loading pattern of I‐125 seeds. Quantitative comparisons of the distribution of relative measured signal intensity and that of the relative predicted dose in the sensitive layer were performed by gamma analysis, similar to intensity‐modulated radiation therapy QA. Results: Data analyses showed high gamma (3%/0.3 mm, global, 20% threshold) passing rates for correct seed loadings and low passing rates with distinguished high gamma value area for incorrect loadings, indicating that possible errors may be detected. The measurement and analysis only required a few extra minutes, significantly shorter than the time to assay the extra verification seeds the physicist already must perform as recommended by TG129. Conclusions: Radio‐luminescent QA can be used to facilitate and assure the implementation of intensity‐modulated, customized plaque loading. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/mp.16003
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        Text: English
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      – SubjectFull: Radioisotope brachytherapy
        Type: general
      – SubjectFull: Monte Carlo method
        Type: general
      – SubjectFull: Imaging phantoms
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      – SubjectFull: Scintillators
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      – TitleFull: Radio‐luminescent imaging for rapid, high‐resolution eye plaque loading verification.
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              Text: Jan2023
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