Synthesis, structure elucidation, biological activity, enzyme inhibition and molecular docking studies of new Schiff bases based on 5-nitroisatin-thiocarbohydrazone.
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| Title: | Synthesis, structure elucidation, biological activity, enzyme inhibition and molecular docking studies of new Schiff bases based on 5-nitroisatin-thiocarbohydrazone. |
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| Authors: | Yakan, Hasan1 (AUTHOR) hasany@omu.edu.tr, Omer, Hiba-H.S.2,3 (AUTHOR), Buruk, Osman2 (AUTHOR), Çakmak, Şükriye4 (AUTHOR), Marah, Sarmad2 (AUTHOR), Veyisoğlu, Aysel4 (AUTHOR), Muğlu, Halit5 (AUTHOR), Ozen, Tevfik1,2 (AUTHOR) tevfkoz@omu.edu.tr, Kütük, Halil2 (AUTHOR) |
| Source: | Journal of Molecular Structure. Apr2023, Vol. 1277, pN.PAG-N.PAG. 1p. |
| Subjects: | Schiff bases, Molecular docking, Oxidant status, Chemical synthesis, Antibacterial agents, Thiourea |
| Abstract: | • New Schiff bases bearing 5-nitroisatin-thiocarbohydrazone have been prepared. • The structures of all compounds have been elucidated by spectroscopic methods. • Total antioxidant capacity and antimicrobial activities of the compounds has been determined. • The enzyme inhibition potentials of synthesized compounds have been evaluated. • Molecular docking calculations have been performed. New Schiff bases bearing 5-nitroisatin-thiocarbohydrazone (1-9) have been prepared. The chemical structures of these compounds have been clarified by spectroscopic methods (IR, 1H NMR, and 13C NMR), and elemental analysis. Besides, they have been tested for antimicrobial activity. The antimicrobial activities of the novel compounds have been evaluated using a twofold serial dilution method for Minimum Inhibitory Concentration (MIC) against three gram-positive bacteria, three gram-negative bacteria, and two fungal pathogens. The obtained data showed that compound 7 has excellent activity against gram-strain-positive and gram-strain-negative bacteria. Compound 7 showed better activity than amoxicillin, which is one of the standard drugs used against the E. faecalis pathogen, but showed the same activity as tetracycline. Synthesized compounds could be formed the basis for the development of better antibacterial agents. The total antioxidant activity of compounds 3 and 5 showed better antioxidant activity than standard BHT, while compounds 4, 8, 7, 2 , and 6 showed better antioxidant activity than standard Trolox. The urease inhibitory effect of compound 7 was better than thiourea. Also, the structure-activity relationship study showed that the scores of molecular models revealed that the compounds with the highest number of binding with urease enzyme were compounds 3 and 7 with total bond numbers of 19 and 18, respectively. [Display omitted] [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Molecular Structure is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 161627954 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Synthesis, structure elucidation, biological activity, enzyme inhibition and molecular docking studies of new Schiff bases based on 5-nitroisatin-thiocarbohydrazone. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Yakan%2C+Hasan%22">Yakan, Hasan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> hasany@omu.edu.tr</i><br /><searchLink fieldCode="AR" term="%22Omer%2C+Hiba-H%2ES%2E%22">Omer, Hiba-H.S.</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Buruk%2C+Osman%22">Buruk, Osman</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Çakmak%2C+Şükriye%22">Çakmak, Şükriye</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Marah%2C+Sarmad%22">Marah, Sarmad</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Veyisoğlu%2C+Aysel%22">Veyisoğlu, Aysel</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Muğlu%2C+Halit%22">Muğlu, Halit</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ozen%2C+Tevfik%22">Ozen, Tevfik</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> tevfkoz@omu.edu.tr</i><br /><searchLink fieldCode="AR" term="%22Kütük%2C+Halil%22">Kütük, Halil</searchLink><relatesTo>2</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Molecular+Structure%22">Journal of Molecular Structure</searchLink>. Apr2023, Vol. 1277, pN.PAG-N.PAG. 1p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Schiff+bases%22">Schiff bases</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+docking%22">Molecular docking</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidant+status%22">Oxidant status</searchLink><br /><searchLink fieldCode="DE" term="%22Chemical+synthesis%22">Chemical synthesis</searchLink><br /><searchLink fieldCode="DE" term="%22Antibacterial+agents%22">Antibacterial agents</searchLink><br /><searchLink fieldCode="DE" term="%22Thiourea%22">Thiourea</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: • New Schiff bases bearing 5-nitroisatin-thiocarbohydrazone have been prepared. • The structures of all compounds have been elucidated by spectroscopic methods. • Total antioxidant capacity and antimicrobial activities of the compounds has been determined. • The enzyme inhibition potentials of synthesized compounds have been evaluated. • Molecular docking calculations have been performed. New Schiff bases bearing 5-nitroisatin-thiocarbohydrazone (1-9) have been prepared. The chemical structures of these compounds have been clarified by spectroscopic methods (IR, 1H NMR, and 13C NMR), and elemental analysis. Besides, they have been tested for antimicrobial activity. The antimicrobial activities of the novel compounds have been evaluated using a twofold serial dilution method for Minimum Inhibitory Concentration (MIC) against three gram-positive bacteria, three gram-negative bacteria, and two fungal pathogens. The obtained data showed that compound 7 has excellent activity against gram-strain-positive and gram-strain-negative bacteria. Compound 7 showed better activity than amoxicillin, which is one of the standard drugs used against the E. faecalis pathogen, but showed the same activity as tetracycline. Synthesized compounds could be formed the basis for the development of better antibacterial agents. The total antioxidant activity of compounds 3 and 5 showed better antioxidant activity than standard BHT, while compounds 4, 8, 7, 2 , and 6 showed better antioxidant activity than standard Trolox. The urease inhibitory effect of compound 7 was better than thiourea. Also, the structure-activity relationship study showed that the scores of molecular models revealed that the compounds with the highest number of binding with urease enzyme were compounds 3 and 7 with total bond numbers of 19 and 18, respectively. [Display omitted] [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Molecular Structure is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.molstruc.2022.134799 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: N.PAG Subjects: – SubjectFull: Schiff bases Type: general – SubjectFull: Molecular docking Type: general – SubjectFull: Oxidant status Type: general – SubjectFull: Chemical synthesis Type: general – SubjectFull: Antibacterial agents Type: general – SubjectFull: Thiourea Type: general Titles: – TitleFull: Synthesis, structure elucidation, biological activity, enzyme inhibition and molecular docking studies of new Schiff bases based on 5-nitroisatin-thiocarbohydrazone. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Yakan, Hasan – PersonEntity: Name: NameFull: Omer, Hiba-H.S. – PersonEntity: Name: NameFull: Buruk, Osman – PersonEntity: Name: NameFull: Çakmak, Şükriye – PersonEntity: Name: NameFull: Marah, Sarmad – PersonEntity: Name: NameFull: Veyisoğlu, Aysel – PersonEntity: Name: NameFull: Muğlu, Halit – PersonEntity: Name: NameFull: Ozen, Tevfik – PersonEntity: Name: NameFull: Kütük, Halil IsPartOfRelationships: – BibEntity: Dates: – D: 05 M: 04 Text: Apr2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 00222860 Numbering: – Type: volume Value: 1277 Titles: – TitleFull: Journal of Molecular Structure Type: main |
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