Computational modeling for osteogenic potential assessment of physical exercises based on loading-induced mechanobiological environments in cortical bone remodeling.
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| Title: | Computational modeling for osteogenic potential assessment of physical exercises based on loading-induced mechanobiological environments in cortical bone remodeling. |
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| Authors: | Mertiya, Abhimanyu Singh1 (AUTHOR), Tiwari, Abhishek Kumar1 (AUTHOR) aktiwari@mnnit.ac.in, Mishra, Ashutosh1 (AUTHOR), Main, Russell P.2 (AUTHOR), Tripathi, Dharmendra3 (AUTHOR), Tiwari, Abhishek1 (AUTHOR) |
| Source: | Biomechanics & Modeling in Mechanobiology. Feb2023, Vol. 22 Issue 1, p281-295. 15p. |
| Subjects: | Bone remodeling, Compact bone, Bone health, Bone growth, Femur, Extracellular fluid, Osseointegration |
| Abstract: | Osteoporosis and disuse can cause bone loss which reduces the weight-bearing strength of long bones. Physical exercise or mechanical loading prevents bone loss as it promotes bone modeling through osteogenesis, i.e., new bone formation. Several studies have observed distinct bone remodeling responses to physical exercises; nevertheless, the underlying mechanism behind such responses is not well established. Loading-induced pore-pressure and fluid motion act as mechanobiological stimuli to bone cells namely osteocytes which further initiate osteoactivities. The shape of loading waveforms also affects the poromechanical environment of bone. Accordingly, the present study hypothesizes that loading waveforms associated with physiological exercises may expose the bone to different mechanobiological stimuli resulting in distinct bone remodeling. A poromechanical finite element model is developed to compute pore-pressure and interstitial fluid velocity in femoral cortical bone tissue (healthy and osteoporotic) subjected to loading waveforms of three physiological exercises namely walking, running, and jumping. The model also computes the mechanobiological stimulus as a function of fluid velocity. The outcomes indicate that pore-pressure and fluid velocity decrease significantly in osteoporotic bone tissue in comparison with healthy tissue. Jumping and running both improve pore-pressure and fluid velocity in healthy and osteoporotic tissues, whereas running significantly enhances mechanobiological stimulus in both the tissues which indicates a possible explanation for distinct bone remodeling to different physical exercises. The present work also suggests that running may be recommended as a potential biomechanical therapeutic to prevent bone loss. Overall, the present work contributes to the area of orthopedic research to develop effective designs of prophylactic exercises to improve bone health. [ABSTRACT FROM AUTHOR] |
| Copyright of Biomechanics & Modeling in Mechanobiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 162078560 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Computational modeling for osteogenic potential assessment of physical exercises based on loading-induced mechanobiological environments in cortical bone remodeling. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Mertiya%2C+Abhimanyu+Singh%22">Mertiya, Abhimanyu Singh</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tiwari%2C+Abhishek+Kumar%22">Tiwari, Abhishek Kumar</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> aktiwari@mnnit.ac.in</i><br /><searchLink fieldCode="AR" term="%22Mishra%2C+Ashutosh%22">Mishra, Ashutosh</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Main%2C+Russell+P%2E%22">Main, Russell P.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tripathi%2C+Dharmendra%22">Tripathi, Dharmendra</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tiwari%2C+Abhishek%22">Tiwari, Abhishek</searchLink><relatesTo>1</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Biomechanics+%26+Modeling+in+Mechanobiology%22">Biomechanics & Modeling in Mechanobiology</searchLink>. Feb2023, Vol. 22 Issue 1, p281-295. 15p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Bone+remodeling%22">Bone remodeling</searchLink><br /><searchLink fieldCode="DE" term="%22Compact+bone%22">Compact bone</searchLink><br /><searchLink fieldCode="DE" term="%22Bone+health%22">Bone health</searchLink><br /><searchLink fieldCode="DE" term="%22Bone+growth%22">Bone growth</searchLink><br /><searchLink fieldCode="DE" term="%22Femur%22">Femur</searchLink><br /><searchLink fieldCode="DE" term="%22Extracellular+fluid%22">Extracellular fluid</searchLink><br /><searchLink fieldCode="DE" term="%22Osseointegration%22">Osseointegration</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Osteoporosis and disuse can cause bone loss which reduces the weight-bearing strength of long bones. Physical exercise or mechanical loading prevents bone loss as it promotes bone modeling through osteogenesis, i.e., new bone formation. Several studies have observed distinct bone remodeling responses to physical exercises; nevertheless, the underlying mechanism behind such responses is not well established. Loading-induced pore-pressure and fluid motion act as mechanobiological stimuli to bone cells namely osteocytes which further initiate osteoactivities. The shape of loading waveforms also affects the poromechanical environment of bone. Accordingly, the present study hypothesizes that loading waveforms associated with physiological exercises may expose the bone to different mechanobiological stimuli resulting in distinct bone remodeling. A poromechanical finite element model is developed to compute pore-pressure and interstitial fluid velocity in femoral cortical bone tissue (healthy and osteoporotic) subjected to loading waveforms of three physiological exercises namely walking, running, and jumping. The model also computes the mechanobiological stimulus as a function of fluid velocity. The outcomes indicate that pore-pressure and fluid velocity decrease significantly in osteoporotic bone tissue in comparison with healthy tissue. Jumping and running both improve pore-pressure and fluid velocity in healthy and osteoporotic tissues, whereas running significantly enhances mechanobiological stimulus in both the tissues which indicates a possible explanation for distinct bone remodeling to different physical exercises. The present work also suggests that running may be recommended as a potential biomechanical therapeutic to prevent bone loss. Overall, the present work contributes to the area of orthopedic research to develop effective designs of prophylactic exercises to improve bone health. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Biomechanics & Modeling in Mechanobiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10237-022-01647-5 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 15 StartPage: 281 Subjects: – SubjectFull: Bone remodeling Type: general – SubjectFull: Compact bone Type: general – SubjectFull: Bone health Type: general – SubjectFull: Bone growth Type: general – SubjectFull: Femur Type: general – SubjectFull: Extracellular fluid Type: general – SubjectFull: Osseointegration Type: general Titles: – TitleFull: Computational modeling for osteogenic potential assessment of physical exercises based on loading-induced mechanobiological environments in cortical bone remodeling. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Mertiya, Abhimanyu Singh – PersonEntity: Name: NameFull: Tiwari, Abhishek Kumar – PersonEntity: Name: NameFull: Mishra, Ashutosh – PersonEntity: Name: NameFull: Main, Russell P. – PersonEntity: Name: NameFull: Tripathi, Dharmendra – PersonEntity: Name: NameFull: Tiwari, Abhishek IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 16177959 Numbering: – Type: volume Value: 22 – Type: issue Value: 1 Titles: – TitleFull: Biomechanics & Modeling in Mechanobiology Type: main |
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