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Ingested Polystyrene Nanospheres Translocate to Placenta and Fetal Tissues in Pregnant Rats: Potential Health Implications.

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Title: Ingested Polystyrene Nanospheres Translocate to Placenta and Fetal Tissues in Pregnant Rats: Potential Health Implications.
Authors: Cary, Chelsea M.1,2 (AUTHOR), DeLoid, Glen M.1 (AUTHOR), Yang, Zhenning1,2 (AUTHOR), Bitounis, Dimitrios1,3 (AUTHOR), Polunas, Marianne4 (AUTHOR), Goedken, Michael J.4 (AUTHOR), Buckley, Brian1 (AUTHOR), Cheatham, Byron5 (AUTHOR), Stapleton, Phoebe A.1,2 (AUTHOR), Demokritou, Philip1,3 (AUTHOR) philip.demokritou@rutgers.edu
Source: Nanomaterials (2079-4991). Feb2023, Vol. 13 Issue 4, p720. 11p.
Subjects: Fetal tissues, Fetus, Fetal brain, Polystyrene, Placenta, Sprague Dawley rats, Fetal heart, Multiple pregnancy
Abstract: Recent studies in experimental animals found that oral exposure to micro- and nano-plastics (MNPs) during pregnancy had multiple adverse effects on outcomes and progeny, although no study has yet identified the translocation of ingested MNPs to the placenta or fetal tissues, which might account for those effects. We therefore assessed the placental and fetal translocation of ingested nanoscale polystyrene MNPs in pregnant rats. Sprague Dawley rats (N = 5) were gavaged on gestational day 19 with 10 mL/kg of 250 µg/mL 25 nm carboxylated polystyrene spheres (PS25C) and sacrificed after 24 h. Hyperspectral imaging of harvested placental and fetal tissues identified abundant PS25C within the placenta and in all fetal tissues examined, including liver, kidney, heart, lung and brain, where they appeared in 10–25 µm clusters. These findings demonstrate that ingested nanoscale polystyrene MNPs can breach the intestinal barrier and subsequently the maternal–fetal barrier of the placenta to access the fetal circulation and all fetal tissues. Further studies are needed to assess the mechanisms of MNP translocation across the intestinal and placental barriers, the effects of MNP polymer, size and other physicochemical properties on translocation, as well as the potential adverse effects of MNP translocation on the developing fetus. [ABSTRACT FROM AUTHOR]
Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Ingested Polystyrene Nanospheres Translocate to Placenta and Fetal Tissues in Pregnant Rats: Potential Health Implications.
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  Data: <searchLink fieldCode="AR" term="%22Cary%2C+Chelsea+M%2E%22">Cary, Chelsea M.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22DeLoid%2C+Glen+M%2E%22">DeLoid, Glen M.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Zhenning%22">Yang, Zhenning</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bitounis%2C+Dimitrios%22">Bitounis, Dimitrios</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Polunas%2C+Marianne%22">Polunas, Marianne</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Goedken%2C+Michael+J%2E%22">Goedken, Michael J.</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Buckley%2C+Brian%22">Buckley, Brian</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cheatham%2C+Byron%22">Cheatham, Byron</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stapleton%2C+Phoebe+A%2E%22">Stapleton, Phoebe A.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Demokritou%2C+Philip%22">Demokritou, Philip</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> philip.demokritou@rutgers.edu</i>
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  Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. Feb2023, Vol. 13 Issue 4, p720. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Fetal+tissues%22">Fetal tissues</searchLink><br /><searchLink fieldCode="DE" term="%22Fetus%22">Fetus</searchLink><br /><searchLink fieldCode="DE" term="%22Fetal+brain%22">Fetal brain</searchLink><br /><searchLink fieldCode="DE" term="%22Polystyrene%22">Polystyrene</searchLink><br /><searchLink fieldCode="DE" term="%22Placenta%22">Placenta</searchLink><br /><searchLink fieldCode="DE" term="%22Sprague+Dawley+rats%22">Sprague Dawley rats</searchLink><br /><searchLink fieldCode="DE" term="%22Fetal+heart%22">Fetal heart</searchLink><br /><searchLink fieldCode="DE" term="%22Multiple+pregnancy%22">Multiple pregnancy</searchLink>
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  Data: Recent studies in experimental animals found that oral exposure to micro- and nano-plastics (MNPs) during pregnancy had multiple adverse effects on outcomes and progeny, although no study has yet identified the translocation of ingested MNPs to the placenta or fetal tissues, which might account for those effects. We therefore assessed the placental and fetal translocation of ingested nanoscale polystyrene MNPs in pregnant rats. Sprague Dawley rats (N = 5) were gavaged on gestational day 19 with 10 mL/kg of 250 µg/mL 25 nm carboxylated polystyrene spheres (PS25C) and sacrificed after 24 h. Hyperspectral imaging of harvested placental and fetal tissues identified abundant PS25C within the placenta and in all fetal tissues examined, including liver, kidney, heart, lung and brain, where they appeared in 10–25 µm clusters. These findings demonstrate that ingested nanoscale polystyrene MNPs can breach the intestinal barrier and subsequently the maternal–fetal barrier of the placenta to access the fetal circulation and all fetal tissues. Further studies are needed to assess the mechanisms of MNP translocation across the intestinal and placental barriers, the effects of MNP polymer, size and other physicochemical properties on translocation, as well as the potential adverse effects of MNP translocation on the developing fetus. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=162385162
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        Value: 10.3390/nano13040720
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      – Code: eng
        Text: English
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        PageCount: 11
        StartPage: 720
    Subjects:
      – SubjectFull: Fetal tissues
        Type: general
      – SubjectFull: Fetus
        Type: general
      – SubjectFull: Fetal brain
        Type: general
      – SubjectFull: Polystyrene
        Type: general
      – SubjectFull: Placenta
        Type: general
      – SubjectFull: Sprague Dawley rats
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      – SubjectFull: Fetal heart
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      – SubjectFull: Multiple pregnancy
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              Text: Feb2023
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