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Preparation of Functional Nanoparticles-Loaded Magnetic Carbon Nanohorn Nanocomposites towards Composite Treatment.

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Title: Preparation of Functional Nanoparticles-Loaded Magnetic Carbon Nanohorn Nanocomposites towards Composite Treatment.
Authors: Rahmania, Fitriani Jati1 (AUTHOR), Huang, Yi-Shou2 (AUTHOR), Workie, Yitayal Admassu1 (AUTHOR), Imae, Toyoko1,2 (AUTHOR) imae@mail.ntust.edu.tw, Kondo, Anna3 (AUTHOR), Miki, Yukiko3 (AUTHOR), Imai, Ritsuko3 (AUTHOR), Nagai, Takashi4 (AUTHOR), Nakagawa, Hiroshi3 (AUTHOR), Kawai, Noriyasu4 (AUTHOR) imae@mail.ntust.edu.tw, Tsutsumiuchi, Kaname3 (AUTHOR)
Source: Nanomaterials (2079-4991). Mar2023, Vol. 13 Issue 5, p839. 18p.
Subjects: Ferric oxide, Gadolinium, Camptothecin, Doxorubicin, Nanocomposite materials, Samarium, Magnetic resonance imaging, Ethylene glycol
Abstract: Combination therapy for cancer is expected for the synergetic effect of different treatments, and the development of promising carrier materials is demanded for new therapeutics. In this study, nanocomposites including functional nanoparticles (NPs) such as samarium oxide NP for radiotherapy and gadolinium oxide NP as a magnetic resonance imaging agent were synthesized and chemically combined with iron oxide NP-embedded or carbon dot-coating iron oxide NP-embedded carbon nanohorn carriers, where iron oxide NP is a hyperthermia reagent and carbon dot exerts effects on photodynamic/photothermal treatments. These nanocomposites exerted potential for delivery of anticancer drugs (doxorubicin, gemcitabine, and camptothecin) even after being coated with poly(ethylene glycol). The co-delivery of these anticancer drugs played better drug-release efficacy than the independent drug delivery, and the thermal and photothermal procedures enlarged the drug release. Thus, the prepared nanocomposites can be expected as materials to develop advanced medication for combination treatment. [ABSTRACT FROM AUTHOR]
Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Preparation of Functional Nanoparticles-Loaded Magnetic Carbon Nanohorn Nanocomposites towards Composite Treatment.
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  Data: <searchLink fieldCode="AR" term="%22Rahmania%2C+Fitriani+Jati%22">Rahmania, Fitriani Jati</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huang%2C+Yi-Shou%22">Huang, Yi-Shou</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Workie%2C+Yitayal+Admassu%22">Workie, Yitayal Admassu</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Imae%2C+Toyoko%22">Imae, Toyoko</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> imae@mail.ntust.edu.tw</i><br /><searchLink fieldCode="AR" term="%22Kondo%2C+Anna%22">Kondo, Anna</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Miki%2C+Yukiko%22">Miki, Yukiko</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Imai%2C+Ritsuko%22">Imai, Ritsuko</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nagai%2C+Takashi%22">Nagai, Takashi</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nakagawa%2C+Hiroshi%22">Nakagawa, Hiroshi</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kawai%2C+Noriyasu%22">Kawai, Noriyasu</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> imae@mail.ntust.edu.tw</i><br /><searchLink fieldCode="AR" term="%22Tsutsumiuchi%2C+Kaname%22">Tsutsumiuchi, Kaname</searchLink><relatesTo>3</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. Mar2023, Vol. 13 Issue 5, p839. 18p.
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  Data: <searchLink fieldCode="DE" term="%22Ferric+oxide%22">Ferric oxide</searchLink><br /><searchLink fieldCode="DE" term="%22Gadolinium%22">Gadolinium</searchLink><br /><searchLink fieldCode="DE" term="%22Camptothecin%22">Camptothecin</searchLink><br /><searchLink fieldCode="DE" term="%22Doxorubicin%22">Doxorubicin</searchLink><br /><searchLink fieldCode="DE" term="%22Nanocomposite+materials%22">Nanocomposite materials</searchLink><br /><searchLink fieldCode="DE" term="%22Samarium%22">Samarium</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Ethylene+glycol%22">Ethylene glycol</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Combination therapy for cancer is expected for the synergetic effect of different treatments, and the development of promising carrier materials is demanded for new therapeutics. In this study, nanocomposites including functional nanoparticles (NPs) such as samarium oxide NP for radiotherapy and gadolinium oxide NP as a magnetic resonance imaging agent were synthesized and chemically combined with iron oxide NP-embedded or carbon dot-coating iron oxide NP-embedded carbon nanohorn carriers, where iron oxide NP is a hyperthermia reagent and carbon dot exerts effects on photodynamic/photothermal treatments. These nanocomposites exerted potential for delivery of anticancer drugs (doxorubicin, gemcitabine, and camptothecin) even after being coated with poly(ethylene glycol). The co-delivery of these anticancer drugs played better drug-release efficacy than the independent drug delivery, and the thermal and photothermal procedures enlarged the drug release. Thus, the prepared nanocomposites can be expected as materials to develop advanced medication for combination treatment. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.3390/nano13050839
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 18
        StartPage: 839
    Subjects:
      – SubjectFull: Ferric oxide
        Type: general
      – SubjectFull: Gadolinium
        Type: general
      – SubjectFull: Camptothecin
        Type: general
      – SubjectFull: Doxorubicin
        Type: general
      – SubjectFull: Nanocomposite materials
        Type: general
      – SubjectFull: Samarium
        Type: general
      – SubjectFull: Magnetic resonance imaging
        Type: general
      – SubjectFull: Ethylene glycol
        Type: general
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      – TitleFull: Preparation of Functional Nanoparticles-Loaded Magnetic Carbon Nanohorn Nanocomposites towards Composite Treatment.
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            NameFull: Rahmania, Fitriani Jati
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            – D: 01
              M: 03
              Text: Mar2023
              Type: published
              Y: 2023
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