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Chemical background of silver nanoparticles interfering with mammalian copper metabolism.

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Title: Chemical background of silver nanoparticles interfering with mammalian copper metabolism.
Authors: Skvortsov, Alexey N.1,2 (AUTHOR), Ilyechova, Ekaterina Yu.1,3,4 (AUTHOR) ilichevaey@itmo.ru, Puchkova, Ludmila V.1,3,4 (AUTHOR)
Source: Journal of Hazardous Materials. Jun2023, Vol. 451, pN.PAG-N.PAG. 1p.
Subjects: Silver nanoparticles, Silver ions, Nanoparticles, Silver compounds, Metabolism
Abstract: The rapidly increasing application of silver nanoparticles (AgNPs) boosts their release into the environment, which raises a reasonable alarm for ecologists and health specialists. This is manifested as increased research devoted to the influence of AgNPs on physiological and cellular processes in various model systems, including mammals. The topic of the present paper is the ability of silver to interfere with copper metabolism, the potential health effects of this interference, and the danger of low silver concentrations to humans. The chemical properties of ionic and nanoparticle silver, supporting the possibility of silver release by AgNPs in extracellular and intracellular compartments of mammals, are discussed. The possibility of justified use of silver for the treatment of some severe diseases, including tumors and viral infections, based on the specific molecular mechanisms of the decrease in copper status by silver ions released from AgNPs is also discussed. [Display omitted] • Metallic Ag can deposit outside the cell but dissolve to Ag(I) inside it. • Copper metabolism is a specific target for biological action of silver ions. • Copper transport systems are unable to discriminate Ag(I) and Cu(I) ions. • Silver compounds and AgNPs affect copper status at very low doses. • Copper metabolic systems have a key role is the fate of AgNPs in biological system. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
Description
Abstract:The rapidly increasing application of silver nanoparticles (AgNPs) boosts their release into the environment, which raises a reasonable alarm for ecologists and health specialists. This is manifested as increased research devoted to the influence of AgNPs on physiological and cellular processes in various model systems, including mammals. The topic of the present paper is the ability of silver to interfere with copper metabolism, the potential health effects of this interference, and the danger of low silver concentrations to humans. The chemical properties of ionic and nanoparticle silver, supporting the possibility of silver release by AgNPs in extracellular and intracellular compartments of mammals, are discussed. The possibility of justified use of silver for the treatment of some severe diseases, including tumors and viral infections, based on the specific molecular mechanisms of the decrease in copper status by silver ions released from AgNPs is also discussed. [Display omitted] • Metallic Ag can deposit outside the cell but dissolve to Ag(I) inside it. • Copper metabolism is a specific target for biological action of silver ions. • Copper transport systems are unable to discriminate Ag(I) and Cu(I) ions. • Silver compounds and AgNPs affect copper status at very low doses. • Copper metabolic systems have a key role is the fate of AgNPs in biological system. [ABSTRACT FROM AUTHOR]
ISSN:03043894
DOI:10.1016/j.jhazmat.2023.131093