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Chemical background of silver nanoparticles interfering with mammalian copper metabolism.

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Title: Chemical background of silver nanoparticles interfering with mammalian copper metabolism.
Authors: Skvortsov, Alexey N.1,2 (AUTHOR), Ilyechova, Ekaterina Yu.1,3,4 (AUTHOR) ilichevaey@itmo.ru, Puchkova, Ludmila V.1,3,4 (AUTHOR)
Source: Journal of Hazardous Materials. Jun2023, Vol. 451, pN.PAG-N.PAG. 1p.
Subjects: Silver nanoparticles, Silver ions, Nanoparticles, Silver compounds, Metabolism
Abstract: The rapidly increasing application of silver nanoparticles (AgNPs) boosts their release into the environment, which raises a reasonable alarm for ecologists and health specialists. This is manifested as increased research devoted to the influence of AgNPs on physiological and cellular processes in various model systems, including mammals. The topic of the present paper is the ability of silver to interfere with copper metabolism, the potential health effects of this interference, and the danger of low silver concentrations to humans. The chemical properties of ionic and nanoparticle silver, supporting the possibility of silver release by AgNPs in extracellular and intracellular compartments of mammals, are discussed. The possibility of justified use of silver for the treatment of some severe diseases, including tumors and viral infections, based on the specific molecular mechanisms of the decrease in copper status by silver ions released from AgNPs is also discussed. [Display omitted] • Metallic Ag can deposit outside the cell but dissolve to Ag(I) inside it. • Copper metabolism is a specific target for biological action of silver ions. • Copper transport systems are unable to discriminate Ag(I) and Cu(I) ions. • Silver compounds and AgNPs affect copper status at very low doses. • Copper metabolic systems have a key role is the fate of AgNPs in biological system. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Hazardous Materials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 162593276
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Chemical background of silver nanoparticles interfering with mammalian copper metabolism.
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  Data: <searchLink fieldCode="AR" term="%22Skvortsov%2C+Alexey+N%2E%22">Skvortsov, Alexey N.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ilyechova%2C+Ekaterina+Yu%2E%22">Ilyechova, Ekaterina Yu.</searchLink><relatesTo>1,3,4</relatesTo> (AUTHOR)<i> ilichevaey@itmo.ru</i><br /><searchLink fieldCode="AR" term="%22Puchkova%2C+Ludmila+V%2E%22">Puchkova, Ludmila V.</searchLink><relatesTo>1,3,4</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Hazardous+Materials%22">Journal of Hazardous Materials</searchLink>. Jun2023, Vol. 451, pN.PAG-N.PAG. 1p.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Silver+nanoparticles%22">Silver nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Silver+ions%22">Silver ions</searchLink><br /><searchLink fieldCode="DE" term="%22Nanoparticles%22">Nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Silver+compounds%22">Silver compounds</searchLink><br /><searchLink fieldCode="DE" term="%22Metabolism%22">Metabolism</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The rapidly increasing application of silver nanoparticles (AgNPs) boosts their release into the environment, which raises a reasonable alarm for ecologists and health specialists. This is manifested as increased research devoted to the influence of AgNPs on physiological and cellular processes in various model systems, including mammals. The topic of the present paper is the ability of silver to interfere with copper metabolism, the potential health effects of this interference, and the danger of low silver concentrations to humans. The chemical properties of ionic and nanoparticle silver, supporting the possibility of silver release by AgNPs in extracellular and intracellular compartments of mammals, are discussed. The possibility of justified use of silver for the treatment of some severe diseases, including tumors and viral infections, based on the specific molecular mechanisms of the decrease in copper status by silver ions released from AgNPs is also discussed. [Display omitted] • Metallic Ag can deposit outside the cell but dissolve to Ag(I) inside it. • Copper metabolism is a specific target for biological action of silver ions. • Copper transport systems are unable to discriminate Ag(I) and Cu(I) ions. • Silver compounds and AgNPs affect copper status at very low doses. • Copper metabolic systems have a key role is the fate of AgNPs in biological system. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Hazardous Materials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1016/j.jhazmat.2023.131093
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Silver nanoparticles
        Type: general
      – SubjectFull: Silver ions
        Type: general
      – SubjectFull: Nanoparticles
        Type: general
      – SubjectFull: Silver compounds
        Type: general
      – SubjectFull: Metabolism
        Type: general
    Titles:
      – TitleFull: Chemical background of silver nanoparticles interfering with mammalian copper metabolism.
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          Name:
            NameFull: Skvortsov, Alexey N.
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            NameFull: Ilyechova, Ekaterina Yu.
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          Name:
            NameFull: Puchkova, Ludmila V.
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          Dates:
            – D: 05
              M: 06
              Text: Jun2023
              Type: published
              Y: 2023
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              Value: 451
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            – TitleFull: Journal of Hazardous Materials
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