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Т1 mapping of rat lungs in 19F MRI using octafluorocyclobutane.

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Title: Т1 mapping of rat lungs in 19F MRI using octafluorocyclobutane.
Authors: Pavlova, Olga S.1,2 (AUTHOR) pavlova.olga@physics.msu.ru, Gulyaev, Mikhail V.1 (AUTHOR), Gervits, Lev L.3 (AUTHOR), Hurshkainen, Anna A.4 (AUTHOR), Nikulin, Anton V.5 (AUTHOR), Puchnin, Viktor M.4 (AUTHOR), Teploukhova, Ekaterina D.2 (AUTHOR), Kuropatkina, Tatyana A.1 (AUTHOR), Anisimov, Nikolay V.1 (AUTHOR), Medvedeva, Nataliya A.6 (AUTHOR), Pirogov, Yury A.2 (AUTHOR)
Source: Magnetic Resonance in Medicine. Jun2023, Vol. 89 Issue 6, p2318-2331. 14p.
Subjects: Lungs, Magnetic resonance imaging, Partial pressure, Pulmonary hypertension, Rats
Abstract: Purpose: To demonstrate the feasibility of using octafluorocyclobutane (OFCB, c‐C4F8) for T1 mapping of lungs in 19F MRI. Methods: The study was performed at 7 T in three healthy rats and three rats with pulmonary hypertension. To increase the sensitivity of 19F MRI, a bent‐shaped RF coil with periodic metal strips structure was used. The double flip angle method was used to calculate normalized transmitting RF field (B1n+) maps and for correcting T1 maps built with the variable flip angle (VFA) method. The ultrashort TE pulse sequence was applied for acquiring MR images throughout the study. Results: The dependencies of OFCB relaxation times on its partial pressure in mixtures with oxygen, air, helium, and argon were obtained. T1 of OFCB linearly depended on its partial pressure with the slope of about 0.35 ms/kPa in the case of free diffusion. RF field inhomogeneity leads to distortion of T1 maps built with the VFA method, and therefore to high standard deviation of T1 in these maps. To improve the accuracy of the T1 maps, the B1n+ maps were applied for VFA correction. This contributed to a 2–3‐fold decrease in the SD of T1 values in the corresponding maps compared with T1 maps calculated without the correction. Three‐dimensional T1 maps were obtained, and the mean T1 in healthy rat lungs was 35 ± 10 ms, and in rat lungs with pulmonary hypertension – 41 ± 9 ms. Conclusion: OFCB has a spin‐rotational relaxation mechanism and can be used for 19F T1 mapping of lungs. The calculated OFCB maps captured ventilation defects induced by edema. [ABSTRACT FROM AUTHOR]
Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Т<subscript>1</subscript> mapping of rat lungs in <superscript>19</superscript>F MRI using octafluorocyclobutane.
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  Data: <searchLink fieldCode="AR" term="%22Pavlova%2C+Olga+S%2E%22">Pavlova, Olga S.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> pavlova.olga@physics.msu.ru</i><br /><searchLink fieldCode="AR" term="%22Gulyaev%2C+Mikhail+V%2E%22">Gulyaev, Mikhail V.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gervits%2C+Lev+L%2E%22">Gervits, Lev L.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hurshkainen%2C+Anna+A%2E%22">Hurshkainen, Anna A.</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nikulin%2C+Anton+V%2E%22">Nikulin, Anton V.</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Puchnin%2C+Viktor+M%2E%22">Puchnin, Viktor M.</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Teploukhova%2C+Ekaterina+D%2E%22">Teploukhova, Ekaterina D.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kuropatkina%2C+Tatyana+A%2E%22">Kuropatkina, Tatyana A.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Anisimov%2C+Nikolay+V%2E%22">Anisimov, Nikolay V.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Medvedeva%2C+Nataliya+A%2E%22">Medvedeva, Nataliya A.</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pirogov%2C+Yury+A%2E%22">Pirogov, Yury A.</searchLink><relatesTo>2</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Jun2023, Vol. 89 Issue 6, p2318-2331. 14p.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Lungs%22">Lungs</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Partial+pressure%22">Partial pressure</searchLink><br /><searchLink fieldCode="DE" term="%22Pulmonary+hypertension%22">Pulmonary hypertension</searchLink><br /><searchLink fieldCode="DE" term="%22Rats%22">Rats</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: To demonstrate the feasibility of using octafluorocyclobutane (OFCB, c‐C4F8) for T1 mapping of lungs in 19F MRI. Methods: The study was performed at 7 T in three healthy rats and three rats with pulmonary hypertension. To increase the sensitivity of 19F MRI, a bent‐shaped RF coil with periodic metal strips structure was used. The double flip angle method was used to calculate normalized transmitting RF field (B1n+) maps and for correcting T1 maps built with the variable flip angle (VFA) method. The ultrashort TE pulse sequence was applied for acquiring MR images throughout the study. Results: The dependencies of OFCB relaxation times on its partial pressure in mixtures with oxygen, air, helium, and argon were obtained. T1 of OFCB linearly depended on its partial pressure with the slope of about 0.35 ms/kPa in the case of free diffusion. RF field inhomogeneity leads to distortion of T1 maps built with the VFA method, and therefore to high standard deviation of T1 in these maps. To improve the accuracy of the T1 maps, the B1n+ maps were applied for VFA correction. This contributed to a 2–3‐fold decrease in the SD of T1 values in the corresponding maps compared with T1 maps calculated without the correction. Three‐dimensional T1 maps were obtained, and the mean T1 in healthy rat lungs was 35 ± 10 ms, and in rat lungs with pulmonary hypertension – 41 ± 9 ms. Conclusion: OFCB has a spin‐rotational relaxation mechanism and can be used for 19F T1 mapping of lungs. The calculated OFCB maps captured ventilation defects induced by edema. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/mrm.29606
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        Text: English
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        PageCount: 14
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    Subjects:
      – SubjectFull: Lungs
        Type: general
      – SubjectFull: Magnetic resonance imaging
        Type: general
      – SubjectFull: Partial pressure
        Type: general
      – SubjectFull: Pulmonary hypertension
        Type: general
      – SubjectFull: Rats
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      – TitleFull: Т1 mapping of rat lungs in 19F MRI using octafluorocyclobutane.
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              Text: Jun2023
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              Y: 2023
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