Shine, Shine, Ruthenium Caged Drug†.
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| Title: | Shine, Shine, Ruthenium Caged Drug†. |
|---|---|
| Authors: | Etchenique, Roberto1 (AUTHOR) rober@qi.fcen.uba.ar, Filevich, Oscar2 (AUTHOR) |
| Source: | Photochemistry & Photobiology. Mar/Apr2023, Vol. 99 Issue 2, p860-862. 3p. |
| Subjects: | Ruthenium, Cancer chemotherapy, Irradiation, Drugs, Platinum |
| Abstract: | This is a highlight on the paper by Bonnet et al.: A Lock‐and‐Kill Anticancer Photoactivated Chemotherapy Agent. which constitutes an important step toward establishing photoactivated chemotherapy (PACT) as a widespread tool to treat different health issues, specially tumors. PACT can be a useful technique to deliver already tested drugs, where the effect of the desired molecule is directed only to its target after light irradiation, even in the cases in which it is difficult to achieve a precise delivery in the desired organ or tissue. Ruthenium‐polipyridyl caged‐compounds are near ideal devices to deliver a drug in that precise fashion, albeit they usually fail in revealing their actual location due to their weak light emission properties. The mentioned work introduces a simple and clever idea: the use of a covalently linked fluorophore to map the caged‐compounds in‐vivo distribution prior to the eventual irradiation to activate the chemotherapy. [ABSTRACT FROM AUTHOR] |
| Copyright of Photochemistry & Photobiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 162824092 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Shine, Shine, Ruthenium Caged Drug<superscript>†</superscript>. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Etchenique%2C+Roberto%22">Etchenique, Roberto</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> rober@qi.fcen.uba.ar</i><br /><searchLink fieldCode="AR" term="%22Filevich%2C+Oscar%22">Filevich, Oscar</searchLink><relatesTo>2</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Photochemistry+%26+Photobiology%22">Photochemistry & Photobiology</searchLink>. Mar/Apr2023, Vol. 99 Issue 2, p860-862. 3p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Ruthenium%22">Ruthenium</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+chemotherapy%22">Cancer chemotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Irradiation%22">Irradiation</searchLink><br /><searchLink fieldCode="DE" term="%22Drugs%22">Drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Platinum%22">Platinum</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: This is a highlight on the paper by Bonnet et al.: A Lock‐and‐Kill Anticancer Photoactivated Chemotherapy Agent. which constitutes an important step toward establishing photoactivated chemotherapy (PACT) as a widespread tool to treat different health issues, specially tumors. PACT can be a useful technique to deliver already tested drugs, where the effect of the desired molecule is directed only to its target after light irradiation, even in the cases in which it is difficult to achieve a precise delivery in the desired organ or tissue. Ruthenium‐polipyridyl caged‐compounds are near ideal devices to deliver a drug in that precise fashion, albeit they usually fail in revealing their actual location due to their weak light emission properties. The mentioned work introduces a simple and clever idea: the use of a covalently linked fluorophore to map the caged‐compounds in‐vivo distribution prior to the eventual irradiation to activate the chemotherapy. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Photochemistry & Photobiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=162824092 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/php.13772 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 3 StartPage: 860 Subjects: – SubjectFull: Ruthenium Type: general – SubjectFull: Cancer chemotherapy Type: general – SubjectFull: Irradiation Type: general – SubjectFull: Drugs Type: general – SubjectFull: Platinum Type: general Titles: – TitleFull: Shine, Shine, Ruthenium Caged Drug†. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Etchenique, Roberto – PersonEntity: Name: NameFull: Filevich, Oscar IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar/Apr2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 00318655 Numbering: – Type: volume Value: 99 – Type: issue Value: 2 Titles: – TitleFull: Photochemistry & Photobiology Type: main |
| ResultId | 1 |
