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Brain BOLD and NIRS response to hyperoxic challenge in sickle cell disease and chronic anemias.

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Title: Brain BOLD and NIRS response to hyperoxic challenge in sickle cell disease and chronic anemias.
Authors: Vu, Chau1 (AUTHOR), Bush, Adam1,2 (AUTHOR), Borzage, Matthew3,4 (AUTHOR), Choi, Soyoung5 (AUTHOR), Coloigner, Julie6,7 (AUTHOR), Farzad, Shayan1 (AUTHOR), Chai, Yaqiong1 (AUTHOR), Coates, Thomas D.8,9 (AUTHOR), Wood, John C.1,10 (AUTHOR) jwood@chla.usc.edu
Source: Magnetic Resonance Imaging (0730725X). Jul2023, Vol. 100, p26-35. 10p.
Subjects: Sickle cell anemia, Cerebral circulation, Oxygen in the blood, Near infrared spectroscopy, Chronic diseases, Anemia
Abstract: Congenital anemias, including sickle cell anemia and thalassemia, are associated with cerebral tissue hypoxia and heightened stroke risks. Recent works in sickle cell disease mouse models have suggested that hyperoxia respiratory challenges can identify regions of the brain having chronic tissue hypoxia. Therefore, this work investigated differences in hyperoxic response and regional cerebral oxygenation between anemic and healthy subjects. A cohort of 38 sickle cell disease subjects (age 22 ± 8 years, female 39%), 25 non-sickle anemic subjects (age 25 ± 11 years, female 52%), and 31 healthy controls (age 25 ± 10 years, female 68%) were examined. A hyperoxic gas challenge was performed with concurrent acquisition of blood oxygen level-dependent (BOLD) MRI and near-infrared spectroscopy (NIRS). In addition to hyperoxia-induced changes in BOLD and NIRS, global measurements of cerebral blood flow, oxygen delivery, and cerebral metabolic rate of oxygen were obtained and compared between the three groups. Regional BOLD changes were not able to identify brain regions of flow limitation in chronically anemic patients. Higher blood oxygen content and tissue oxygenation were observed during hyperoxia gas challenge. Both control and anemic groups demonstrated lower blood flow, oxygen delivery, and metabolic rate compared to baseline, but the oxygen metabolism in anemic subjects were abnormally low during hyperoxic exposure. These results indicated that hyperoxic respiratory challenge could not be used to identify chronically ischemic brain. Furthermore, the low hyperoxia-induced metabolic rate suggested potential negative effects of prolonged oxygen therapy and required further studies to evaluate the risk for hyperoxia-induced oxygen toxicity and cerebral dysfunction. [ABSTRACT FROM AUTHOR]
Copyright of Magnetic Resonance Imaging (0730725X) is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Brain BOLD and NIRS response to hyperoxic challenge in sickle cell disease and chronic anemias.
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  Data: <searchLink fieldCode="DE" term="%22Sickle+cell+anemia%22">Sickle cell anemia</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+circulation%22">Cerebral circulation</searchLink><br /><searchLink fieldCode="DE" term="%22Oxygen+in+the+blood%22">Oxygen in the blood</searchLink><br /><searchLink fieldCode="DE" term="%22Near+infrared+spectroscopy%22">Near infrared spectroscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Chronic+diseases%22">Chronic diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Anemia%22">Anemia</searchLink>
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  Data: Congenital anemias, including sickle cell anemia and thalassemia, are associated with cerebral tissue hypoxia and heightened stroke risks. Recent works in sickle cell disease mouse models have suggested that hyperoxia respiratory challenges can identify regions of the brain having chronic tissue hypoxia. Therefore, this work investigated differences in hyperoxic response and regional cerebral oxygenation between anemic and healthy subjects. A cohort of 38 sickle cell disease subjects (age 22 ± 8 years, female 39%), 25 non-sickle anemic subjects (age 25 ± 11 years, female 52%), and 31 healthy controls (age 25 ± 10 years, female 68%) were examined. A hyperoxic gas challenge was performed with concurrent acquisition of blood oxygen level-dependent (BOLD) MRI and near-infrared spectroscopy (NIRS). In addition to hyperoxia-induced changes in BOLD and NIRS, global measurements of cerebral blood flow, oxygen delivery, and cerebral metabolic rate of oxygen were obtained and compared between the three groups. Regional BOLD changes were not able to identify brain regions of flow limitation in chronically anemic patients. Higher blood oxygen content and tissue oxygenation were observed during hyperoxia gas challenge. Both control and anemic groups demonstrated lower blood flow, oxygen delivery, and metabolic rate compared to baseline, but the oxygen metabolism in anemic subjects were abnormally low during hyperoxic exposure. These results indicated that hyperoxic respiratory challenge could not be used to identify chronically ischemic brain. Furthermore, the low hyperoxia-induced metabolic rate suggested potential negative effects of prolonged oxygen therapy and required further studies to evaluate the risk for hyperoxia-induced oxygen toxicity and cerebral dysfunction. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Magnetic Resonance Imaging (0730725X) is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.mri.2023.03.002
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      – Code: eng
        Text: English
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        PageCount: 10
        StartPage: 26
    Subjects:
      – SubjectFull: Sickle cell anemia
        Type: general
      – SubjectFull: Cerebral circulation
        Type: general
      – SubjectFull: Oxygen in the blood
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      – SubjectFull: Near infrared spectroscopy
        Type: general
      – SubjectFull: Chronic diseases
        Type: general
      – SubjectFull: Anemia
        Type: general
    Titles:
      – TitleFull: Brain BOLD and NIRS response to hyperoxic challenge in sickle cell disease and chronic anemias.
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            – D: 01
              M: 07
              Text: Jul2023
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              Y: 2023
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