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3D printed peripheral vascular stents based on degradable poly(trimethylene carbonate‐b‐(L‐lactide‐ran‐glycolide)) terpolymer.

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Title: 3D printed peripheral vascular stents based on degradable poly(trimethylene carbonate‐b‐(L‐lactide‐ran‐glycolide)) terpolymer.
Authors: Ni, Na1 (AUTHOR) na.ni@sjtu.edu.cn, Fan, Tiantang2,3 (AUTHOR), Ye, Wuyou2 (AUTHOR), Xia, Qi2 (AUTHOR), Liu, Dongyang2 (AUTHOR), Qin, Jingwen4 (AUTHOR), Fan, Zhongyong2 (AUTHOR) zyfan@fudan.edu.cn, Liu, Qing4 (AUTHOR) qliu@ametcorp.com
Source: Polymers for Advanced Technologies. May2023, Vol. 34 Issue 5, p1739-1751. 13p.
Subjects: Laser engraving, Cyclopropane, Biomedical materials, Three-dimensional printing, Activation energy, Carbonates
Abstract: Poly(L‐lactic acid) (PLLA) is a biocompatible material and has found its application in bioresorbable vascular stents (BVS). However, the crystallization of pure PLLA makes it brittle as a medical implant device. In this work, the biodegradable poly(1,3‐trimethylene carbonate‐b‐(L‐lactide‐ran‐glycolide acid)) (PTLG) terpolymers with improved mechanical performance were developed and processed into peripheral vascular stents by a novel 3D 4‐axial printing technology. The PTLG terpolymers were successfully synthesized by ring‐opening copolymerization of L‐lactic acid (LLA), 1,3‐trimethylene carbonate (PTMC) and glycolide acid (GA) units. The crystallinity and mechanical properties of the PTLG terpolymers with various degradation rate depends on the chain sequence structure and the component contents. Compared with the stent prepared by laser engraving, the peripheral vascular stent prepared by the 3D 4‐axial printing technology exhibit a finer structure and smoother strut surface. It was found that both the strut diameters and the molecular weight of PTMC affect the radial force of the stents and that the apparent activation energy of thermal decomposition of the stents is mainly influenced by the molecular weight of PTMC and the component ratio. Therefore, the addition of the PTMC segment can effectively improve the flexibility of the PTLG terpolymer stent and the 3D printed PTLG terpolymer‐based stent. Furthermore, CCK‐8 and live/dead staining suggested that the stents have good biocompatibility. [ABSTRACT FROM AUTHOR]
Copyright of Polymers for Advanced Technologies is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: 3D printed peripheral vascular stents based on degradable poly(trimethylene carbonate‐b‐(L‐lactide‐ran‐glycolide)) terpolymer.
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  Data: <searchLink fieldCode="AR" term="%22Ni%2C+Na%22">Ni, Na</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> na.ni@sjtu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Fan%2C+Tiantang%22">Fan, Tiantang</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ye%2C+Wuyou%22">Ye, Wuyou</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xia%2C+Qi%22">Xia, Qi</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Dongyang%22">Liu, Dongyang</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Qin%2C+Jingwen%22">Qin, Jingwen</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fan%2C+Zhongyong%22">Fan, Zhongyong</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> zyfan@fudan.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Liu%2C+Qing%22">Liu, Qing</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> qliu@ametcorp.com</i>
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  Data: <searchLink fieldCode="JN" term="%22Polymers+for+Advanced+Technologies%22">Polymers for Advanced Technologies</searchLink>. May2023, Vol. 34 Issue 5, p1739-1751. 13p.
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  Data: <searchLink fieldCode="DE" term="%22Laser+engraving%22">Laser engraving</searchLink><br /><searchLink fieldCode="DE" term="%22Cyclopropane%22">Cyclopropane</searchLink><br /><searchLink fieldCode="DE" term="%22Biomedical+materials%22">Biomedical materials</searchLink><br /><searchLink fieldCode="DE" term="%22Three-dimensional+printing%22">Three-dimensional printing</searchLink><br /><searchLink fieldCode="DE" term="%22Activation+energy%22">Activation energy</searchLink><br /><searchLink fieldCode="DE" term="%22Carbonates%22">Carbonates</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Poly(L‐lactic acid) (PLLA) is a biocompatible material and has found its application in bioresorbable vascular stents (BVS). However, the crystallization of pure PLLA makes it brittle as a medical implant device. In this work, the biodegradable poly(1,3‐trimethylene carbonate‐b‐(L‐lactide‐ran‐glycolide acid)) (PTLG) terpolymers with improved mechanical performance were developed and processed into peripheral vascular stents by a novel 3D 4‐axial printing technology. The PTLG terpolymers were successfully synthesized by ring‐opening copolymerization of L‐lactic acid (LLA), 1,3‐trimethylene carbonate (PTMC) and glycolide acid (GA) units. The crystallinity and mechanical properties of the PTLG terpolymers with various degradation rate depends on the chain sequence structure and the component contents. Compared with the stent prepared by laser engraving, the peripheral vascular stent prepared by the 3D 4‐axial printing technology exhibit a finer structure and smoother strut surface. It was found that both the strut diameters and the molecular weight of PTMC affect the radial force of the stents and that the apparent activation energy of thermal decomposition of the stents is mainly influenced by the molecular weight of PTMC and the component ratio. Therefore, the addition of the PTMC segment can effectively improve the flexibility of the PTLG terpolymer stent and the 3D printed PTLG terpolymer‐based stent. Furthermore, CCK‐8 and live/dead staining suggested that the stents have good biocompatibility. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Polymers for Advanced Technologies is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/pat.6007
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        Text: English
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        PageCount: 13
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      – SubjectFull: Laser engraving
        Type: general
      – SubjectFull: Cyclopropane
        Type: general
      – SubjectFull: Biomedical materials
        Type: general
      – SubjectFull: Three-dimensional printing
        Type: general
      – SubjectFull: Activation energy
        Type: general
      – SubjectFull: Carbonates
        Type: general
    Titles:
      – TitleFull: 3D printed peripheral vascular stents based on degradable poly(trimethylene carbonate‐b‐(L‐lactide‐ran‐glycolide)) terpolymer.
        Type: main
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          Name:
            NameFull: Ni, Na
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            NameFull: Fan, Tiantang
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            NameFull: Ye, Wuyou
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            – D: 01
              M: 05
              Text: May2023
              Type: published
              Y: 2023
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              Value: 34
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