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The preparation and effect of Sr-doped phosphate coatings on the ion release and cytocompatibility of biodegradable zinc.

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Title: The preparation and effect of Sr-doped phosphate coatings on the ion release and cytocompatibility of biodegradable zinc.
Authors: Feng, Boxuan1 (AUTHOR), Ren, Ran1 (AUTHOR), Yuan, Guangyin1,2 (AUTHOR) gyyuan@sjtu.edu.cn, Pei, Jia1,2 (AUTHOR) jpei@sjtu.edu.cn
Source: Materials Letters. Jun2023, Vol. 341, pN.PAG-N.PAG. 1p.
Subjects: Phosphate coating, Cytocompatibility, Strontium, Zinc, Ions, Metal ions, Phosphate removal (Water purification)
Abstract: • Sr-doped phosphate coatings were prepared on biodegradable Zn for regulating the ion release and biocompatibility. • The optimized Sr-P coating simultaneously controlled Zn2+ ion and Sr2+ ion release. • The optimized Sr-P coated Zn exhibited enhanced cytocompatibility due to the low concentration of Zn2+ ion and Sr2+ ion. The high concentration of Zn2+ ion locally released due to the degradation of zinc (Zn) implants causes cytotoxicity, hindering the clinical application of Zn. Herein, bioactive Sr2+ doped zinc phosphate (Sr-P) coatings were prepared by a feasible chemical conversion method to improve the biocompatibility of biomedical Zn. The reaction thermodynamics were regulated by different reaction parameters to further regulate the chemical composition and surface morphology, and in vitro release of metal ions of the Sr-P coatings. The Sr-P coating with the most obvious inhibition effect on Zn2+ ion release was selected for the in vitro cell assays. Sr-P coating presents a promising surface modification strategy to improve biocompatibility for biodegradable Zn. [ABSTRACT FROM AUTHOR]
Copyright of Materials Letters is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 162977553
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PubTypeId: academicJournal
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: The preparation and effect of Sr-doped phosphate coatings on the ion release and cytocompatibility of biodegradable zinc.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Feng%2C+Boxuan%22">Feng, Boxuan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ren%2C+Ran%22">Ren, Ran</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yuan%2C+Guangyin%22">Yuan, Guangyin</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> gyyuan@sjtu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Pei%2C+Jia%22">Pei, Jia</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> jpei@sjtu.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Materials+Letters%22">Materials Letters</searchLink>. Jun2023, Vol. 341, pN.PAG-N.PAG. 1p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Phosphate+coating%22">Phosphate coating</searchLink><br /><searchLink fieldCode="DE" term="%22Cytocompatibility%22">Cytocompatibility</searchLink><br /><searchLink fieldCode="DE" term="%22Strontium%22">Strontium</searchLink><br /><searchLink fieldCode="DE" term="%22Zinc%22">Zinc</searchLink><br /><searchLink fieldCode="DE" term="%22Ions%22">Ions</searchLink><br /><searchLink fieldCode="DE" term="%22Metal+ions%22">Metal ions</searchLink><br /><searchLink fieldCode="DE" term="%22Phosphate+removal+%28Water+purification%29%22">Phosphate removal (Water purification)</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: • Sr-doped phosphate coatings were prepared on biodegradable Zn for regulating the ion release and biocompatibility. • The optimized Sr-P coating simultaneously controlled Zn2+ ion and Sr2+ ion release. • The optimized Sr-P coated Zn exhibited enhanced cytocompatibility due to the low concentration of Zn2+ ion and Sr2+ ion. The high concentration of Zn2+ ion locally released due to the degradation of zinc (Zn) implants causes cytotoxicity, hindering the clinical application of Zn. Herein, bioactive Sr2+ doped zinc phosphate (Sr-P) coatings were prepared by a feasible chemical conversion method to improve the biocompatibility of biomedical Zn. The reaction thermodynamics were regulated by different reaction parameters to further regulate the chemical composition and surface morphology, and in vitro release of metal ions of the Sr-P coatings. The Sr-P coating with the most obvious inhibition effect on Zn2+ ion release was selected for the in vitro cell assays. Sr-P coating presents a promising surface modification strategy to improve biocompatibility for biodegradable Zn. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Materials Letters is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.matlet.2023.134281
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Phosphate coating
        Type: general
      – SubjectFull: Cytocompatibility
        Type: general
      – SubjectFull: Strontium
        Type: general
      – SubjectFull: Zinc
        Type: general
      – SubjectFull: Ions
        Type: general
      – SubjectFull: Metal ions
        Type: general
      – SubjectFull: Phosphate removal (Water purification)
        Type: general
    Titles:
      – TitleFull: The preparation and effect of Sr-doped phosphate coatings on the ion release and cytocompatibility of biodegradable zinc.
        Type: main
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      – PersonEntity:
          Name:
            NameFull: Feng, Boxuan
      – PersonEntity:
          Name:
            NameFull: Ren, Ran
      – PersonEntity:
          Name:
            NameFull: Yuan, Guangyin
      – PersonEntity:
          Name:
            NameFull: Pei, Jia
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          Dates:
            – D: 15
              M: 06
              Text: Jun2023
              Type: published
              Y: 2023
          Identifiers:
            – Type: issn-print
              Value: 0167577X
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              Value: 341
          Titles:
            – TitleFull: Materials Letters
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