View in EDS

The human placenta: new perspectives on its formation and function during early pregnancy.

Saved in:
Bibliographic Details
Title: The human placenta: new perspectives on its formation and function during early pregnancy.
Authors: Burton, Graham J.1 gjb2@cam.ac.uk, Jauniaux, Eric2
Source: Proceedings of the Royal Society B: Biological Sciences. 4/19/2023, Vol. 290 Issue 1997, p1-11. 11p.
Subjects: Trophoblast, Placenta, Pregnancy complications, Pregnancy, Decidua, Morphogenesis
Abstract: The placenta has evolved to support the development of the embryo and fetus during the different intrauterine periods of life. By necessity, its development must precede that of the embryo. There is now evidence that during embryogenesis and organogenesis, the development of the human placenta is supported by histotrophic nutrition secreted from endometrial glands rather than maternal blood. These secretions provide a plentiful supply of glucose, lipids, glycoproteins and growth factors that stimulate rapid proliferation and differentiation of the villous trophoblast. Furthermore, evidence from endometrial gland organoids indicates that expression and secretion of these products are upregulated following sequential exposure to oestrogen, progesterone and trophoblastic and decidual hormones, in particular prolactin. Hence, a feed-forward signalling dialogue is proposed among the trophoblast, decidua and glands that enables the placenta to stimulate its own development, independent of that of the embryo. Many common complications of pregnancy represent a spectrum of disorders associated with deficient trophoblast proliferation. Increasing evidence suggests that this spectrum is mirrored by one of impaired decidualization, potentially compromising histotroph secretion through diminished prolactin secretion and reduced gland function. Optimizing endometrial wellbeing prior to conception may therefore help to prevent common pregnancy complications, such as miscarriage, growth restriction and pre-eclampsia. [ABSTRACT FROM AUTHOR]
Copyright of Proceedings of the Royal Society B: Biological Sciences is the property of Royal Society and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 163343389
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: The human placenta: new perspectives on its formation and function during early pregnancy.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Burton%2C+Graham+J%2E%22">Burton, Graham J.</searchLink><relatesTo>1</relatesTo><i> gjb2@cam.ac.uk</i><br /><searchLink fieldCode="AR" term="%22Jauniaux%2C+Eric%22">Jauniaux, Eric</searchLink><relatesTo>2</relatesTo>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Proceedings+of+the+Royal+Society+B%3A+Biological+Sciences%22">Proceedings of the Royal Society B: Biological Sciences</searchLink>. 4/19/2023, Vol. 290 Issue 1997, p1-11. 11p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Trophoblast%22">Trophoblast</searchLink><br /><searchLink fieldCode="DE" term="%22Placenta%22">Placenta</searchLink><br /><searchLink fieldCode="DE" term="%22Pregnancy+complications%22">Pregnancy complications</searchLink><br /><searchLink fieldCode="DE" term="%22Pregnancy%22">Pregnancy</searchLink><br /><searchLink fieldCode="DE" term="%22Decidua%22">Decidua</searchLink><br /><searchLink fieldCode="DE" term="%22Morphogenesis%22">Morphogenesis</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The placenta has evolved to support the development of the embryo and fetus during the different intrauterine periods of life. By necessity, its development must precede that of the embryo. There is now evidence that during embryogenesis and organogenesis, the development of the human placenta is supported by histotrophic nutrition secreted from endometrial glands rather than maternal blood. These secretions provide a plentiful supply of glucose, lipids, glycoproteins and growth factors that stimulate rapid proliferation and differentiation of the villous trophoblast. Furthermore, evidence from endometrial gland organoids indicates that expression and secretion of these products are upregulated following sequential exposure to oestrogen, progesterone and trophoblastic and decidual hormones, in particular prolactin. Hence, a feed-forward signalling dialogue is proposed among the trophoblast, decidua and glands that enables the placenta to stimulate its own development, independent of that of the embryo. Many common complications of pregnancy represent a spectrum of disorders associated with deficient trophoblast proliferation. Increasing evidence suggests that this spectrum is mirrored by one of impaired decidualization, potentially compromising histotroph secretion through diminished prolactin secretion and reduced gland function. Optimizing endometrial wellbeing prior to conception may therefore help to prevent common pregnancy complications, such as miscarriage, growth restriction and pre-eclampsia. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Proceedings of the Royal Society B: Biological Sciences is the property of Royal Society and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=163343389
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1098/rspb.2023.0191
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 11
        StartPage: 1
    Subjects:
      – SubjectFull: Trophoblast
        Type: general
      – SubjectFull: Placenta
        Type: general
      – SubjectFull: Pregnancy complications
        Type: general
      – SubjectFull: Pregnancy
        Type: general
      – SubjectFull: Decidua
        Type: general
      – SubjectFull: Morphogenesis
        Type: general
    Titles:
      – TitleFull: The human placenta: new perspectives on its formation and function during early pregnancy.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Burton, Graham J.
      – PersonEntity:
          Name:
            NameFull: Jauniaux, Eric
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 19
              M: 04
              Text: 4/19/2023
              Type: published
              Y: 2023
          Identifiers:
            – Type: issn-print
              Value: 09628452
          Numbering:
            – Type: volume
              Value: 290
            – Type: issue
              Value: 1997
          Titles:
            – TitleFull: Proceedings of the Royal Society B: Biological Sciences
              Type: main
ResultId 1