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Integer Programming Applied to Intensity-Modulated Radiation Therapy Treatment Planning.

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Title: Integer Programming Applied to Intensity-Modulated Radiation Therapy Treatment Planning.
Authors: Lee, Eva1,2 eva.lee@isye.gatech.edu, Fox, Tim2, Crocker, Ian2
Source: Annals of Operations Research. Mar2003, Vol. 119 Issue 1-4, p165-181. 17p.
Subjects: Integer programming, Radiotherapy, Medical radiology, Electrotherapeutics, Physiological effects of radiation, Collimators, Scientific apparatus & instruments
Abstract: In intensity-modulated radiation therapy (IMRT) not only is the shape of the beam controlled, but combinations of open and closed multileaf collimators modulate the intensity as well. In this paper, we offer a mixed integer programming approach which allows optimization over beamlet fluence weights as well as beam and couch angles. Computational strategies, including a constraint and column generator, a specialized set-based branching scheme, a geometric heuristic procedure, and the use of disjunctive cuts, are described. Our algorithmic design thus far has been motivated by clinical cases. Numerical tests on real patient cases reveal that good treatment plans are returned within 30 minutes. The MIP plans consistently provide superior tumor coverage and conformity, as well as dose homogeneity within the tumor region while maintaining a low irradiation to important critical and normal tissues. [ABSTRACT FROM AUTHOR]
Copyright of Annals of Operations Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Integer Programming Applied to Intensity-Modulated Radiation Therapy Treatment Planning.
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  Data: <searchLink fieldCode="JN" term="%22Annals+of+Operations+Research%22">Annals of Operations Research</searchLink>. Mar2003, Vol. 119 Issue 1-4, p165-181. 17p.
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  Data: In intensity-modulated radiation therapy (IMRT) not only is the shape of the beam controlled, but combinations of open and closed multileaf collimators modulate the intensity as well. In this paper, we offer a mixed integer programming approach which allows optimization over beamlet fluence weights as well as beam and couch angles. Computational strategies, including a constraint and column generator, a specialized set-based branching scheme, a geometric heuristic procedure, and the use of disjunctive cuts, are described. Our algorithmic design thus far has been motivated by clinical cases. Numerical tests on real patient cases reveal that good treatment plans are returned within 30 minutes. The MIP plans consistently provide superior tumor coverage and conformity, as well as dose homogeneity within the tumor region while maintaining a low irradiation to important critical and normal tissues. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Annals of Operations Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1023/A:1022938707934
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        Text: English
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        PageCount: 17
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      – SubjectFull: Integer programming
        Type: general
      – SubjectFull: Radiotherapy
        Type: general
      – SubjectFull: Medical radiology
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      – SubjectFull: Electrotherapeutics
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      – SubjectFull: Physiological effects of radiation
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      – SubjectFull: Collimators
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      – SubjectFull: Scientific apparatus & instruments
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      – TitleFull: Integer Programming Applied to Intensity-Modulated Radiation Therapy Treatment Planning.
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              Text: Mar2003
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