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Polyethylenimine-functionalized fibroin nanoparticles as a potential oral delivery system for BCS class-IV drugs, a case study of furosemide.

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Title: Polyethylenimine-functionalized fibroin nanoparticles as a potential oral delivery system for BCS class-IV drugs, a case study of furosemide.
Authors: Pham, Duy Toan1 (AUTHOR) pdtoan@ctu.edu.vn, Nguyen, Thanh Lich1 (AUTHOR), Nguyen, Thi Truc Linh1 (AUTHOR), Nguyen, Thi Truc Phuong1 (AUTHOR), Ho, Tuan Kiet1 (AUTHOR), Nguyen, Ngoc Yen2 (AUTHOR), Tran, Van De3 (AUTHOR), Ha, Thi Kim Quy1 (AUTHOR)
Source: Journal of Materials Science. Jun2023, Vol. 58 Issue 23, p9660-9674. 15p. 1 Color Photograph, 1 Black and White Photograph, 3 Charts, 5 Graphs.
Subjects: Furosemide, Drug solubility, Drug adsorption, Drug delivery systems, Silk fibroin, Infrared spectra
Abstract: Limited studies have exploited the silk fibroin potential as an oral drug delivery system. Herein, this study developed and characterized the polyethylenimine-functionalized fibroin nanoparticles (PEI-FNP) and the FNP (as a reference), loaded with furosemide, a Biopharmaceutics Classification System (BCS) class-IV drug, for oral application. Furosemide was incorporated into the systems by two different methods of co-condensation and adsorption. The optimal formulas possessed particles with sizes of ~ 200 nm, positive charges of + 60 mV, silk-II structured confirmed by infrared spectra, appropriate drug entrapment efficiencies of ~ 65%, and insignificant hemolysis action at concentrations of up to 1 mg/mL. Additionally, the PEI-FNP significantly increased the drug solubility up to 1.5-folds. Kinetically, the drug adsorption processes followed the physical type and pseudo-second-order model. In the simulated gastrointestinal condition, the particles could protect the furosemide from the stomach acidic environment. Interestingly, the particles release profiles in the intestinal condition were heavily dependent on the formulation fabrication methods. Particles prepared by the co-condensation method demonstrated an initial burst release phase, followed by a sustained release phase. Conversely, the adsorption method yielded particles with an initial sustained release phase, followed by a burst release phase. Conclusively, the PEI-FNP showed much potentials in improving the oral bioavailability of furosemide. Proven by this case, PEI-FNP could be further explored to be a potential oral delivery system for BCS class-IV drugs. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Materials Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Polyethylenimine-functionalized fibroin nanoparticles as a potential oral delivery system for BCS class-IV drugs, a case study of furosemide.
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  Data: <searchLink fieldCode="AR" term="%22Pham%2C+Duy+Toan%22">Pham, Duy Toan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> pdtoan@ctu.edu.vn</i><br /><searchLink fieldCode="AR" term="%22Nguyen%2C+Thanh+Lich%22">Nguyen, Thanh Lich</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nguyen%2C+Thi+Truc+Linh%22">Nguyen, Thi Truc Linh</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nguyen%2C+Thi+Truc+Phuong%22">Nguyen, Thi Truc Phuong</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ho%2C+Tuan+Kiet%22">Ho, Tuan Kiet</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nguyen%2C+Ngoc+Yen%22">Nguyen, Ngoc Yen</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tran%2C+Van+De%22">Tran, Van De</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ha%2C+Thi+Kim+Quy%22">Ha, Thi Kim Quy</searchLink><relatesTo>1</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Materials+Science%22">Journal of Materials Science</searchLink>. Jun2023, Vol. 58 Issue 23, p9660-9674. 15p. 1 Color Photograph, 1 Black and White Photograph, 3 Charts, 5 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Furosemide%22">Furosemide</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+solubility%22">Drug solubility</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+adsorption%22">Drug adsorption</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+delivery+systems%22">Drug delivery systems</searchLink><br /><searchLink fieldCode="DE" term="%22Silk+fibroin%22">Silk fibroin</searchLink><br /><searchLink fieldCode="DE" term="%22Infrared+spectra%22">Infrared spectra</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Limited studies have exploited the silk fibroin potential as an oral drug delivery system. Herein, this study developed and characterized the polyethylenimine-functionalized fibroin nanoparticles (PEI-FNP) and the FNP (as a reference), loaded with furosemide, a Biopharmaceutics Classification System (BCS) class-IV drug, for oral application. Furosemide was incorporated into the systems by two different methods of co-condensation and adsorption. The optimal formulas possessed particles with sizes of ~ 200 nm, positive charges of + 60 mV, silk-II structured confirmed by infrared spectra, appropriate drug entrapment efficiencies of ~ 65%, and insignificant hemolysis action at concentrations of up to 1 mg/mL. Additionally, the PEI-FNP significantly increased the drug solubility up to 1.5-folds. Kinetically, the drug adsorption processes followed the physical type and pseudo-second-order model. In the simulated gastrointestinal condition, the particles could protect the furosemide from the stomach acidic environment. Interestingly, the particles release profiles in the intestinal condition were heavily dependent on the formulation fabrication methods. Particles prepared by the co-condensation method demonstrated an initial burst release phase, followed by a sustained release phase. Conversely, the adsorption method yielded particles with an initial sustained release phase, followed by a burst release phase. Conclusively, the PEI-FNP showed much potentials in improving the oral bioavailability of furosemide. Proven by this case, PEI-FNP could be further explored to be a potential oral delivery system for BCS class-IV drugs. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Materials Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10853-023-08640-y
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      – Code: eng
        Text: English
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        PageCount: 15
        StartPage: 9660
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      – SubjectFull: Furosemide
        Type: general
      – SubjectFull: Drug solubility
        Type: general
      – SubjectFull: Drug adsorption
        Type: general
      – SubjectFull: Drug delivery systems
        Type: general
      – SubjectFull: Silk fibroin
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      – SubjectFull: Infrared spectra
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              Text: Jun2023
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