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Photobiomodulation at molecular, cellular, and systemic levels.

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Title: Photobiomodulation at molecular, cellular, and systemic levels.
Authors: da Silva, Thayssa Gomes1 (AUTHOR) thayssa.biomed@gmail.com, Ribeiro, Rickson Souza1 (AUTHOR), Mencalha, Andre Luiz1 (AUTHOR), de Souza Fonseca, Adenilson1,2 (AUTHOR)
Source: Lasers in Medical Science. 6/13/2023, Vol. 38 Issue 1, p1-11. 11p.
Subjects: Photobiomodulation therapy, Light emitting diodes, Nonionizing radiation, Transcription factors, Inflammation
Abstract: Since the reporting of Endre Mester's results, researchers have investigated the biological effects induced by non-ionizing radiation emitted from low-power lasers. Recently, owing to the use of light-emitting diodes (LEDs), the term photobiomodulation (PBM) has been used. However, the molecular, cellular, and systemic effects involved in PBM are still under investigation, and a better understanding of these effects could improve clinical safety and efficacy. Our aim was to review the molecular, cellular, and systemic effects involved in PBM to elucidate the levels of biological complexity. PBM occurs as a consequence of photon-photoacceptor interactions, which lead to the production of trigger molecules capable of inducing signaling, effector molecules, and transcription factors, which feature it at the molecular level. These molecules and factors are responsible for cellular effects, such as cell proliferation, migration, differentiation, and apoptosis, which feature PBM at the cellular level. Finally, molecular and cellular effects are responsible for systemic effects, such as modulation of the inflammatory process, promotion of tissue repair and wound healing, reduction of edema and pain, and improvement of muscle performance, which features PBM at the systemic level. [ABSTRACT FROM AUTHOR]
Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Photobiomodulation at molecular, cellular, and systemic levels.
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  Data: <searchLink fieldCode="AR" term="%22da+Silva%2C+Thayssa+Gomes%22">da Silva, Thayssa Gomes</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> thayssa.biomed@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Ribeiro%2C+Rickson+Souza%22">Ribeiro, Rickson Souza</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mencalha%2C+Andre+Luiz%22">Mencalha, Andre Luiz</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Souza+Fonseca%2C+Adenilson%22">de Souza Fonseca, Adenilson</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Lasers+in+Medical+Science%22">Lasers in Medical Science</searchLink>. 6/13/2023, Vol. 38 Issue 1, p1-11. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Photobiomodulation+therapy%22">Photobiomodulation therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Light+emitting+diodes%22">Light emitting diodes</searchLink><br /><searchLink fieldCode="DE" term="%22Nonionizing+radiation%22">Nonionizing radiation</searchLink><br /><searchLink fieldCode="DE" term="%22Transcription+factors%22">Transcription factors</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammation%22">Inflammation</searchLink>
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  Label: Abstract
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  Data: Since the reporting of Endre Mester's results, researchers have investigated the biological effects induced by non-ionizing radiation emitted from low-power lasers. Recently, owing to the use of light-emitting diodes (LEDs), the term photobiomodulation (PBM) has been used. However, the molecular, cellular, and systemic effects involved in PBM are still under investigation, and a better understanding of these effects could improve clinical safety and efficacy. Our aim was to review the molecular, cellular, and systemic effects involved in PBM to elucidate the levels of biological complexity. PBM occurs as a consequence of photon-photoacceptor interactions, which lead to the production of trigger molecules capable of inducing signaling, effector molecules, and transcription factors, which feature it at the molecular level. These molecules and factors are responsible for cellular effects, such as cell proliferation, migration, differentiation, and apoptosis, which feature PBM at the cellular level. Finally, molecular and cellular effects are responsible for systemic effects, such as modulation of the inflammatory process, promotion of tissue repair and wound healing, reduction of edema and pain, and improvement of muscle performance, which features PBM at the systemic level. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10103-023-03801-6
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        Text: English
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        Type: general
      – SubjectFull: Light emitting diodes
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      – SubjectFull: Nonionizing radiation
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      – SubjectFull: Transcription factors
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              Text: 6/13/2023
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