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Light-driven micromotor swarm induced in-situ polymerization and synergistic photothermal therapy.

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Title: Light-driven micromotor swarm induced in-situ polymerization and synergistic photothermal therapy.
Authors: Li, Zeqi1 (AUTHOR), Fu, Shaoming1 (AUTHOR), Li, Huaan2 (AUTHOR), Chen, Bin1 (AUTHOR), Xie, Dazhi1 (AUTHOR), Fu, Dongmei1 (AUTHOR), Feng, Ye1 (AUTHOR), Gao, Chao1 (AUTHOR), Liu, Suyi1 (AUTHOR), Wilson, Daniela A.3 (AUTHOR), Tu, Yingfeng1,2 (AUTHOR) tuyingfeng1@smu.edu.cn, Peng, Fei1 (AUTHOR) pengf26@mail.sysu.edu.cn
Source: Chemical Engineering Journal. Jul2023, Vol. 468, pN.PAG-N.PAG. 1p.
Subjects: Polymerization, Biological systems, Micromotors, Copper, Cell survival, Photothermal effect
Abstract: • Maneuverable swarming of micromotors induces targeted polymerization of dopamine. • Micromotors providing heat for in situ polymerization in bio-system. • In situ polymerization of dopamine generate heat and block cellular nutrient supply. • Cellular targeting photothermal therapy with low tumor cell viability. Photothermal therapy (PTT) is a promising tumor therapy with advantages of spatially directed light, minimal invasiveness, and reduced treatment time. However, poor accumulation of photothermal agents at the tumor site and insufficient penetration of NIR light severely restrict PTT therapeutic efficacy. Herein, we report the maneuverable swarming of micromotors induces targeted polymerization of dopamine, and offers a synergistic photothermal strategy to eradicate tumors precisely and efficiently. Under NIR, the Au/Cu micromotors successfully swarm to the illumination area. In situ polymerization of dopamine was induced thereby producing photothermal polydopamine bound to the glioma cells to block the cellular nutrient supply and generate heat, showing great potential in precise and efficient photothermal therapy. Remarkably, by accurate in-situ polymerization of polydopamine, thus sufficient contact between the photothermal agent and the tumor cells, a cellular targeting photothermal therapy with low tumor cell viability, can be achieved. This is also the first study to report on the controllable swarm of motors to provide propulsion and heat for in situ polymerization in biological systems.. [ABSTRACT FROM AUTHOR]
Copyright of Chemical Engineering Journal is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 164278395
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Light-driven micromotor swarm induced in-situ polymerization and synergistic photothermal therapy.
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  Data: <searchLink fieldCode="AR" term="%22Li%2C+Zeqi%22">Li, Zeqi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fu%2C+Shaoming%22">Fu, Shaoming</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Huaan%22">Li, Huaan</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Bin%22">Chen, Bin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xie%2C+Dazhi%22">Xie, Dazhi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fu%2C+Dongmei%22">Fu, Dongmei</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Feng%2C+Ye%22">Feng, Ye</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gao%2C+Chao%22">Gao, Chao</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Suyi%22">Liu, Suyi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wilson%2C+Daniela+A%2E%22">Wilson, Daniela A.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tu%2C+Yingfeng%22">Tu, Yingfeng</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> tuyingfeng1@smu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Peng%2C+Fei%22">Peng, Fei</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> pengf26@mail.sysu.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Chemical+Engineering+Journal%22">Chemical Engineering Journal</searchLink>. Jul2023, Vol. 468, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Polymerization%22">Polymerization</searchLink><br /><searchLink fieldCode="DE" term="%22Biological+systems%22">Biological systems</searchLink><br /><searchLink fieldCode="DE" term="%22Micromotors%22">Micromotors</searchLink><br /><searchLink fieldCode="DE" term="%22Copper%22">Copper</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+survival%22">Cell survival</searchLink><br /><searchLink fieldCode="DE" term="%22Photothermal+effect%22">Photothermal effect</searchLink>
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  Label: Abstract
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  Data: • Maneuverable swarming of micromotors induces targeted polymerization of dopamine. • Micromotors providing heat for in situ polymerization in bio-system. • In situ polymerization of dopamine generate heat and block cellular nutrient supply. • Cellular targeting photothermal therapy with low tumor cell viability. Photothermal therapy (PTT) is a promising tumor therapy with advantages of spatially directed light, minimal invasiveness, and reduced treatment time. However, poor accumulation of photothermal agents at the tumor site and insufficient penetration of NIR light severely restrict PTT therapeutic efficacy. Herein, we report the maneuverable swarming of micromotors induces targeted polymerization of dopamine, and offers a synergistic photothermal strategy to eradicate tumors precisely and efficiently. Under NIR, the Au/Cu micromotors successfully swarm to the illumination area. In situ polymerization of dopamine was induced thereby producing photothermal polydopamine bound to the glioma cells to block the cellular nutrient supply and generate heat, showing great potential in precise and efficient photothermal therapy. Remarkably, by accurate in-situ polymerization of polydopamine, thus sufficient contact between the photothermal agent and the tumor cells, a cellular targeting photothermal therapy with low tumor cell viability, can be achieved. This is also the first study to report on the controllable swarm of motors to provide propulsion and heat for in situ polymerization in biological systems.. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Chemical Engineering Journal is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=164278395
RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.cej.2023.143393
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Polymerization
        Type: general
      – SubjectFull: Biological systems
        Type: general
      – SubjectFull: Micromotors
        Type: general
      – SubjectFull: Copper
        Type: general
      – SubjectFull: Cell survival
        Type: general
      – SubjectFull: Photothermal effect
        Type: general
    Titles:
      – TitleFull: Light-driven micromotor swarm induced in-situ polymerization and synergistic photothermal therapy.
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              Text: Jul2023
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