Dietary flavanols restore hippocampal-dependent memory in older adults with lower diet quality and lower habitual flavanol consumption.
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| Title: | Dietary flavanols restore hippocampal-dependent memory in older adults with lower diet quality and lower habitual flavanol consumption. |
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| Authors: | Brickman, Adam M.1,2,3 amb2139@columbia.edu, Lok-Kin Yeung1,2,3, Alschuler, Daniel M.4, Ottaviani, Javier I.5, Kuhnle, Gunter G. C.6, Sloan, Richard P.4,7, Luttmann-Gibson, Heike8,9, Copeland, Trisha8, Schroeter, Hagen5, Sesso, Howard D.8,10, Manson, JoAnn E.8,10, Wall, Melanie4,7, Small, Scott A.1,2,3,7 sas68@columbia.edu |
| Source: | Proceedings of the National Academy of Sciences of the United States of America. 6/6/2023, Vol. 120 Issue 23, p1-11. 17p. |
| Subjects: | Older people, Cognitive aging, Flavanols, Diet, Food habits |
| Abstract: | Dietary flavanols are food constituents found in certain fruits and vegetables that have been linked to cognitive aging. Previous studies suggested that consumption of dietary flavanols might specifically be associated with the hippocampal-dependent memory component of cognitive aging and that memory benefits of a flavanol intervention might depend on habitual diet quality. Here, we tested these hypotheses in the context of a large-scale study of 3,562 older adults, who were randomly assigned to a 3-y intervention of cocoa extract (500 mg of cocoa flavanols per day) or a placebo [(COcoa Supplement and Multivitamin Outcomes Study) COSMOS-Web, NCT04582617]. Using the alternative Healthy Eating Index in all participants and a urine-based biomarker of flavanol intake in a subset of participants [n = 1,361], we show that habitual flavanol consumption and diet quality at baseline are positively and selectively correlated with hippocampal-dependent memory. While the prespecified primary end point testing for an intervention-related improvement in memory in all participants after 1 y was not statistically significant, the flavanol intervention restored memory among participants in lower tertiles of habitual diet quality or habitual flavanol consumption. Increases in the flavanol biomarker over the course of the trial were associated with improving memory. Collectively, our results allow dietary flavanols to be considered in the context of a depletion-repletion paradigm and suggest that low flavanol consumption can act as a driver of the hippocampal-dependent component of cognitive aging. [ABSTRACT FROM AUTHOR] |
| Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 164319725 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Dietary flavanols restore hippocampal-dependent memory in older adults with lower diet quality and lower habitual flavanol consumption. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Brickman%2C+Adam+M%2E%22">Brickman, Adam M.</searchLink><relatesTo>1,2,3</relatesTo><i> amb2139@columbia.edu</i><br /><searchLink fieldCode="AR" term="%22Lok-Kin+Yeung%22">Lok-Kin Yeung</searchLink><relatesTo>1,2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Alschuler%2C+Daniel+M%2E%22">Alschuler, Daniel M.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Ottaviani%2C+Javier+I%2E%22">Ottaviani, Javier I.</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Kuhnle%2C+Gunter+G%2E+C%2E%22">Kuhnle, Gunter G. C.</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Sloan%2C+Richard+P%2E%22">Sloan, Richard P.</searchLink><relatesTo>4,7</relatesTo><br /><searchLink fieldCode="AR" term="%22Luttmann-Gibson%2C+Heike%22">Luttmann-Gibson, Heike</searchLink><relatesTo>8,9</relatesTo><br /><searchLink fieldCode="AR" term="%22Copeland%2C+Trisha%22">Copeland, Trisha</searchLink><relatesTo>8</relatesTo><br /><searchLink fieldCode="AR" term="%22Schroeter%2C+Hagen%22">Schroeter, Hagen</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Sesso%2C+Howard+D%2E%22">Sesso, Howard D.</searchLink><relatesTo>8,10</relatesTo><br /><searchLink fieldCode="AR" term="%22Manson%2C+JoAnn+E%2E%22">Manson, JoAnn E.</searchLink><relatesTo>8,10</relatesTo><br /><searchLink fieldCode="AR" term="%22Wall%2C+Melanie%22">Wall, Melanie</searchLink><relatesTo>4,7</relatesTo><br /><searchLink fieldCode="AR" term="%22Small%2C+Scott+A%2E%22">Small, Scott A.</searchLink><relatesTo>1,2,3,7</relatesTo><i> sas68@columbia.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink>. 6/6/2023, Vol. 120 Issue 23, p1-11. 17p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Older+people%22">Older people</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+aging%22">Cognitive aging</searchLink><br /><searchLink fieldCode="DE" term="%22Flavanols%22">Flavanols</searchLink><br /><searchLink fieldCode="DE" term="%22Diet%22">Diet</searchLink><br /><searchLink fieldCode="DE" term="%22Food+habits%22">Food habits</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Dietary flavanols are food constituents found in certain fruits and vegetables that have been linked to cognitive aging. Previous studies suggested that consumption of dietary flavanols might specifically be associated with the hippocampal-dependent memory component of cognitive aging and that memory benefits of a flavanol intervention might depend on habitual diet quality. Here, we tested these hypotheses in the context of a large-scale study of 3,562 older adults, who were randomly assigned to a 3-y intervention of cocoa extract (500 mg of cocoa flavanols per day) or a placebo [(COcoa Supplement and Multivitamin Outcomes Study) COSMOS-Web, NCT04582617]. Using the alternative Healthy Eating Index in all participants and a urine-based biomarker of flavanol intake in a subset of participants [n = 1,361], we show that habitual flavanol consumption and diet quality at baseline are positively and selectively correlated with hippocampal-dependent memory. While the prespecified primary end point testing for an intervention-related improvement in memory in all participants after 1 y was not statistically significant, the flavanol intervention restored memory among participants in lower tertiles of habitual diet quality or habitual flavanol consumption. Increases in the flavanol biomarker over the course of the trial were associated with improving memory. Collectively, our results allow dietary flavanols to be considered in the context of a depletion-repletion paradigm and suggest that low flavanol consumption can act as a driver of the hippocampal-dependent component of cognitive aging. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1073/pnas.2216932120 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 17 StartPage: 1 Subjects: – SubjectFull: Older people Type: general – SubjectFull: Cognitive aging Type: general – SubjectFull: Flavanols Type: general – SubjectFull: Diet Type: general – SubjectFull: Food habits Type: general Titles: – TitleFull: Dietary flavanols restore hippocampal-dependent memory in older adults with lower diet quality and lower habitual flavanol consumption. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Brickman, Adam M. – PersonEntity: Name: NameFull: Lok-Kin Yeung – PersonEntity: Name: NameFull: Alschuler, Daniel M. – PersonEntity: Name: NameFull: Ottaviani, Javier I. – PersonEntity: Name: NameFull: Kuhnle, Gunter G. C. – PersonEntity: Name: NameFull: Sloan, Richard P. – PersonEntity: Name: NameFull: Luttmann-Gibson, Heike – PersonEntity: Name: NameFull: Copeland, Trisha – PersonEntity: Name: NameFull: Schroeter, Hagen – PersonEntity: Name: NameFull: Sesso, Howard D. – PersonEntity: Name: NameFull: Manson, JoAnn E. – PersonEntity: Name: NameFull: Wall, Melanie – PersonEntity: Name: NameFull: Small, Scott A. IsPartOfRelationships: – BibEntity: Dates: – D: 06 M: 06 Text: 6/6/2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 00278424 Numbering: – Type: volume Value: 120 – Type: issue Value: 23 Titles: – TitleFull: Proceedings of the National Academy of Sciences of the United States of America Type: main |
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