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Using T1 mapping indices to evaluate muscle function and predict conservative treatment outcomes in diabetic patients with peripheral arterial disease.

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Title: Using T1 mapping indices to evaluate muscle function and predict conservative treatment outcomes in diabetic patients with peripheral arterial disease.
Authors: Lin, Yu-Ching1 (AUTHOR), Fu, Tieh-Cheng2 (AUTHOR), Lin, Gigin3 (AUTHOR), Ng, Shu-Hang3 (AUTHOR), Yeh, Chi-Hsiao4 (AUTHOR), Ng, Soh-Chin5 (AUTHOR), Chang, Tsun-Ching1 (AUTHOR), Juan, Yu-Hsiang3,6 (AUTHOR) jonat126@yahoo.com.tw
Source: European Radiology. Jul2023, Vol. 33 Issue 7, p4927-4937. 11p. 1 Diagram, 4 Charts, 1 Graph, 1 Map.
Subjects: Ankle brachial index, Peripheral vascular diseases, Conservative treatment, Treatment effectiveness, Transluminal angioplasty, Pearson correlation (Statistics), Calf muscles
Abstract: Objectives: To investigate interstitial muscle fibrosis via T1 mapping indices and its relationships with muscle function and conservative treatment outcomes. Methods: A total of 49 DM patients with PAD were prospectively recruited from 2016 to 2017. All PAD patients underwent pre-treatment MRI with conservative treatment via a rehabilitation program and antiplatelet therapy. The need to require percutaneous transluminal angioplasty intervention was recorded as intolerance to conservative treatment outcomes. We quantified calf interstitial muscle fibrosis using T1 mapping indices (native T1, post-contrast T1, and the extracellular volume fraction [ECV]). Muscle function was evaluated using a 6-min walking test (6MWT) and a 3-min stepping test (3MST). PAD patients were divided into two groups according to their tolerance or intolerance of the conservative treatment. Pearson's correlation, reproducibility, and multivariable Cox hazard analyses were performed with p < 0.05 indicating statistical significance. Results: Among the T1 mapping indices in the posterior compartment of the calf in PAD patients, the native T1 value was significantly correlated with 6MWT (r = −0.422, p = 0.010) and 3MST (r = −0.427, p = 0.009). All T1 mapping indices showed excellent intra-observer and inter-observer correlations. ECV was an independent predictor of conservative treatment intolerance (average ECV, hazard ratio: 1.045, 95% confidence interval: 1.011–1.079, p = 0.009). Conclusions: T1 mapping measurements are reproducible with excellent intra-observer and inter-observer correlations. T1 mapping indices may be predictive of treatment and functional outcomes and carry promise in patient evaluation. Trial registration: Clinical Trials Identifier: NCT 02850432. Key Points: • T1 mapping measurements of the calf muscles are reproducible with excellent intra-observer and inter-observer correlations (0.98 and 0.95 for anterior and posterior compartment muscle extracellular volume matrix [ECV] measurements, respectively). • ECV is shown to independently predict conservative treatment intolerance. • T1 mapping indices may be predictive of treatment and functional outcomes and carry promise in patient evaluation. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Using T1 mapping indices to evaluate muscle function and predict conservative treatment outcomes in diabetic patients with peripheral arterial disease.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lin%2C+Yu-Ching%22&quot;&gt;Lin, Yu-Ching&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Fu%2C+Tieh-Cheng%22&quot;&gt;Fu, Tieh-Cheng&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lin%2C+Gigin%22&quot;&gt;Lin, Gigin&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ng%2C+Shu-Hang%22&quot;&gt;Ng, Shu-Hang&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Yeh%2C+Chi-Hsiao%22&quot;&gt;Yeh, Chi-Hsiao&lt;/searchLink&gt;&lt;relatesTo&gt;4&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ng%2C+Soh-Chin%22&quot;&gt;Ng, Soh-Chin&lt;/searchLink&gt;&lt;relatesTo&gt;5&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Chang%2C+Tsun-Ching%22&quot;&gt;Chang, Tsun-Ching&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Juan%2C+Yu-Hsiang%22&quot;&gt;Juan, Yu-Hsiang&lt;/searchLink&gt;&lt;relatesTo&gt;3,6&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; jonat126@yahoo.com.tw&lt;/i&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22European+Radiology%22&quot;&gt;European Radiology&lt;/searchLink&gt;. Jul2023, Vol. 33 Issue 7, p4927-4937. 11p. 1 Diagram, 4 Charts, 1 Graph, 1 Map.
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objectives: To investigate interstitial muscle fibrosis via T1 mapping indices and its relationships with muscle function and conservative treatment outcomes. Methods: A total of 49 DM patients with PAD were prospectively recruited from 2016 to 2017. All PAD patients underwent pre-treatment MRI with conservative treatment via a rehabilitation program and antiplatelet therapy. The need to require percutaneous transluminal angioplasty intervention was recorded as intolerance to conservative treatment outcomes. We quantified calf interstitial muscle fibrosis using T1 mapping indices (native T1, post-contrast T1, and the extracellular volume fraction [ECV]). Muscle function was evaluated using a 6-min walking test (6MWT) and a 3-min stepping test (3MST). PAD patients were divided into two groups according to their tolerance or intolerance of the conservative treatment. Pearson&#39;s correlation, reproducibility, and multivariable Cox hazard analyses were performed with p &lt; 0.05 indicating statistical significance. Results: Among the T1 mapping indices in the posterior compartment of the calf in PAD patients, the native T1 value was significantly correlated with 6MWT (r = −0.422, p = 0.010) and 3MST (r = −0.427, p = 0.009). All T1 mapping indices showed excellent intra-observer and inter-observer correlations. ECV was an independent predictor of conservative treatment intolerance (average ECV, hazard ratio: 1.045, 95% confidence interval: 1.011–1.079, p = 0.009). Conclusions: T1 mapping measurements are reproducible with excellent intra-observer and inter-observer correlations. T1 mapping indices may be predictive of treatment and functional outcomes and carry promise in patient evaluation. Trial registration: Clinical Trials Identifier: NCT 02850432. Key Points: • T1 mapping measurements of the calf muscles are reproducible with excellent intra-observer and inter-observer correlations (0.98 and 0.95 for anterior and posterior compartment muscle extracellular volume matrix [ECV] measurements, respectively). • ECV is shown to independently predict conservative treatment intolerance. • T1 mapping indices may be predictive of treatment and functional outcomes and carry promise in patient evaluation. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00330-023-09392-8
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        Text: English
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        PageCount: 11
        StartPage: 4927
    Subjects:
      – SubjectFull: Ankle brachial index
        Type: general
      – SubjectFull: Peripheral vascular diseases
        Type: general
      – SubjectFull: Conservative treatment
        Type: general
      – SubjectFull: Treatment effectiveness
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      – SubjectFull: Transluminal angioplasty
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      – SubjectFull: Pearson correlation (Statistics)
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      – SubjectFull: Calf muscles
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    Titles:
      – TitleFull: Using T1 mapping indices to evaluate muscle function and predict conservative treatment outcomes in diabetic patients with peripheral arterial disease.
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              M: 07
              Text: Jul2023
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              Y: 2023
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