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Investigation of the Influence of Wound-Treatment-Relevant Buffer Systems on the Colloidal and Optical Properties of Gold Nanoparticles.

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Title: Investigation of the Influence of Wound-Treatment-Relevant Buffer Systems on the Colloidal and Optical Properties of Gold Nanoparticles.
Authors: Selmani, Atiđa1 (AUTHOR) atida.selmani@uni-graz.at, Jeitler, Ramona1,2 (AUTHOR) carolin.tetyczka@rcpe.at, Auinger, Michael3 (AUTHOR) michael.auinger@tuwien.ac.at, Tetyczka, Carolin2 (AUTHOR), Banzer, Peter4 (AUTHOR) peter.banzer@uni-graz.at, Kantor, Brian4 (AUTHOR) brian.kantor@uni-graz.at, Leitinger, Gerd5 (AUTHOR) gerd.leitinger@medunigraz.at, Roblegg, Eva1,2 (AUTHOR) eva.roblegg@uni-graz.at
Source: Nanomaterials (2079-4991). Jun2023, Vol. 13 Issue 12, p1878. 21p.
Subjects: Colloids, Gold nanoparticles, Optical properties, Ionic strength, Wound healing, Intermolecular interactions
Abstract: Biocompatible gold nanoparticles (AuNPs) are used in wound healing due to their radical scavenging activity. They shorten wound healing time by, for example, improving re-epithelialization and promoting the formation of new connective tissue. Another approach that promotes wound healing through cell proliferation while inhibiting bacterial growth is an acidic microenvironment, which can be achieved with acid-forming buffers. Accordingly, a combination of these two approaches appears promising and is the focus of the present study. Here, 18 nm and 56 nm gold NP (Au) were prepared with Turkevich reduction synthesis using design-of-experiments methodology, and the influence of pH and ionic strength on their behaviour was investigated. The citrate buffer had a pronounced effect on the stability of AuNPs due to the more complex intermolecular interactions, which was also confirmed by the changes in optical properties. In contrast, AuNPs dispersed in lactate and phosphate buffer were stable at therapeutically relevant ionic strength, regardless of their size. Simulation of the local pH distribution near the particle surface also showed a steep pH gradient for particles smaller than 100 nm. This suggests that the healing potential is further enhanced by a more acidic environment at the particle surface, making this strategy a promising approach. [ABSTRACT FROM AUTHOR]
Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Investigation of the Influence of Wound-Treatment-Relevant Buffer Systems on the Colloidal and Optical Properties of Gold Nanoparticles.
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  Data: <searchLink fieldCode="AR" term="%22Selmani%2C+Atiđa%22">Selmani, Atiđa</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> atida.selmani@uni-graz.at</i><br /><searchLink fieldCode="AR" term="%22Jeitler%2C+Ramona%22">Jeitler, Ramona</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> carolin.tetyczka@rcpe.at</i><br /><searchLink fieldCode="AR" term="%22Auinger%2C+Michael%22">Auinger, Michael</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> michael.auinger@tuwien.ac.at</i><br /><searchLink fieldCode="AR" term="%22Tetyczka%2C+Carolin%22">Tetyczka, Carolin</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Banzer%2C+Peter%22">Banzer, Peter</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> peter.banzer@uni-graz.at</i><br /><searchLink fieldCode="AR" term="%22Kantor%2C+Brian%22">Kantor, Brian</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> brian.kantor@uni-graz.at</i><br /><searchLink fieldCode="AR" term="%22Leitinger%2C+Gerd%22">Leitinger, Gerd</searchLink><relatesTo>5</relatesTo> (AUTHOR)<i> gerd.leitinger@medunigraz.at</i><br /><searchLink fieldCode="AR" term="%22Roblegg%2C+Eva%22">Roblegg, Eva</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> eva.roblegg@uni-graz.at</i>
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  Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. Jun2023, Vol. 13 Issue 12, p1878. 21p.
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  Data: <searchLink fieldCode="DE" term="%22Colloids%22">Colloids</searchLink><br /><searchLink fieldCode="DE" term="%22Gold+nanoparticles%22">Gold nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Optical+properties%22">Optical properties</searchLink><br /><searchLink fieldCode="DE" term="%22Ionic+strength%22">Ionic strength</searchLink><br /><searchLink fieldCode="DE" term="%22Wound+healing%22">Wound healing</searchLink><br /><searchLink fieldCode="DE" term="%22Intermolecular+interactions%22">Intermolecular interactions</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Biocompatible gold nanoparticles (AuNPs) are used in wound healing due to their radical scavenging activity. They shorten wound healing time by, for example, improving re-epithelialization and promoting the formation of new connective tissue. Another approach that promotes wound healing through cell proliferation while inhibiting bacterial growth is an acidic microenvironment, which can be achieved with acid-forming buffers. Accordingly, a combination of these two approaches appears promising and is the focus of the present study. Here, 18 nm and 56 nm gold NP (Au) were prepared with Turkevich reduction synthesis using design-of-experiments methodology, and the influence of pH and ionic strength on their behaviour was investigated. The citrate buffer had a pronounced effect on the stability of AuNPs due to the more complex intermolecular interactions, which was also confirmed by the changes in optical properties. In contrast, AuNPs dispersed in lactate and phosphate buffer were stable at therapeutically relevant ionic strength, regardless of their size. Simulation of the local pH distribution near the particle surface also showed a steep pH gradient for particles smaller than 100 nm. This suggests that the healing potential is further enhanced by a more acidic environment at the particle surface, making this strategy a promising approach. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3390/nano13121878
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      – Code: eng
        Text: English
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        PageCount: 21
        StartPage: 1878
    Subjects:
      – SubjectFull: Colloids
        Type: general
      – SubjectFull: Gold nanoparticles
        Type: general
      – SubjectFull: Optical properties
        Type: general
      – SubjectFull: Ionic strength
        Type: general
      – SubjectFull: Wound healing
        Type: general
      – SubjectFull: Intermolecular interactions
        Type: general
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      – TitleFull: Investigation of the Influence of Wound-Treatment-Relevant Buffer Systems on the Colloidal and Optical Properties of Gold Nanoparticles.
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            – D: 15
              M: 06
              Text: Jun2023
              Type: published
              Y: 2023
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