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Gold Nanorods as Radiopharmaceutical Carriers: Preparation and Preliminary Radiobiological In Vitro Tests.

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Title: Gold Nanorods as Radiopharmaceutical Carriers: Preparation and Preliminary Radiobiological In Vitro Tests.
Authors: Binelli, Ludovica1,2 (AUTHOR) ludovica.binelli@uniroma3.it, Dini, Valentina3,4 (AUTHOR) barbara.deberardis@iss.it, Amatori, Simone1 (AUTHOR) simone.amatori@uniroma3.it, Scotognella, Teresa5 (AUTHOR) teresa.scotognella@policlinicogemelli.it, Giordano, Alessandro5,6 (AUTHOR) alessandro.giordano@unicatt.it, De Berardis, Barbara3 (AUTHOR), Bertelà, Federica1 (AUTHOR) federica.bertela@uniroma3.it, Battocchio, Chiara1 (AUTHOR) chiara.battocchio@uniroma3.it, Iucci, Giovanna1 (AUTHOR) giovanna.iucci@uniroma3.it, Fratoddi, Ilaria7 (AUTHOR) ilaria.fratoddi@uniroma1.it, Cartoni, Antonella7 (AUTHOR) antonella.cartoni@uniroma1.it, Venditti, Iole1 (AUTHOR) valentina.dini@iss.it
Source: Nanomaterials (2079-4991). Jul2023, Vol. 13 Issue 13, p1898. 13p.
Subjects: Auger effect, Surface plasmon resonance, Radioisotopes, Nanorods, Nuclides, Radiopharmaceuticals, Irradiation, Synchrotron radiation, Radioactive decay
Abstract: Low-energy electrons (Auger electrons) can be produced via the interaction of photons with gold atoms in gold nanorods (AuNRs). These electrons are similar to those emitted during the decay of technetium-99m (99mTc), a radioactive nuclide widely used for diagnostics in nuclear medicine. Auger and internal conversion (IC) electron emitters appropriately targeted to the DNA of tumors cells may, therefore, represent a new radiotherapeutic approach. 99mTc radiopharmaceuticals, which are used for diagnosis, could indeed be used in theragnostic fields when loaded on AuNRs and delivered to a tumor site. This work aims to provide a proof of concept (i) to evaluate AuNRs as carriers of 99mTc-based radiopharmaceuticals, and (ii) to evaluate the efficacy of Auger electrons emitted by photon-irradiated AuNRs in inducing radio-induced damage in T98G cells, thus mimicking the effect of Auger electrons emitted during the decay of 99mTc used in clinical settings. Data are presented on AuNRs' chemical characterization (with an aspect ratio of 3.2 and Surface Plasmon Resonance bands at 520 and 680 nm) and the loading of pharmaceuticals (after 99mTc decay) on their surface. Spectroscopic characterizations, such as UV-Vis and synchrotron radiation-induced X-ray photoelectron (SR-XPS) spectroscopies, were performed to investigate the drug–AuNR interaction. Finally, preliminary radiobiological data on cell killing with AuNRs are presented. [ABSTRACT FROM AUTHOR]
Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
  Group: Ti
  Data: Gold Nanorods as Radiopharmaceutical Carriers: Preparation and Preliminary Radiobiological In Vitro Tests.
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  Data: <searchLink fieldCode="AR" term="%22Binelli%2C+Ludovica%22">Binelli, Ludovica</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> ludovica.binelli@uniroma3.it</i><br /><searchLink fieldCode="AR" term="%22Dini%2C+Valentina%22">Dini, Valentina</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<i> barbara.deberardis@iss.it</i><br /><searchLink fieldCode="AR" term="%22Amatori%2C+Simone%22">Amatori, Simone</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> simone.amatori@uniroma3.it</i><br /><searchLink fieldCode="AR" term="%22Scotognella%2C+Teresa%22">Scotognella, Teresa</searchLink><relatesTo>5</relatesTo> (AUTHOR)<i> teresa.scotognella@policlinicogemelli.it</i><br /><searchLink fieldCode="AR" term="%22Giordano%2C+Alessandro%22">Giordano, Alessandro</searchLink><relatesTo>5,6</relatesTo> (AUTHOR)<i> alessandro.giordano@unicatt.it</i><br /><searchLink fieldCode="AR" term="%22De+Berardis%2C+Barbara%22">De Berardis, Barbara</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bertelà%2C+Federica%22">Bertelà, Federica</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> federica.bertela@uniroma3.it</i><br /><searchLink fieldCode="AR" term="%22Battocchio%2C+Chiara%22">Battocchio, Chiara</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> chiara.battocchio@uniroma3.it</i><br /><searchLink fieldCode="AR" term="%22Iucci%2C+Giovanna%22">Iucci, Giovanna</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> giovanna.iucci@uniroma3.it</i><br /><searchLink fieldCode="AR" term="%22Fratoddi%2C+Ilaria%22">Fratoddi, Ilaria</searchLink><relatesTo>7</relatesTo> (AUTHOR)<i> ilaria.fratoddi@uniroma1.it</i><br /><searchLink fieldCode="AR" term="%22Cartoni%2C+Antonella%22">Cartoni, Antonella</searchLink><relatesTo>7</relatesTo> (AUTHOR)<i> antonella.cartoni@uniroma1.it</i><br /><searchLink fieldCode="AR" term="%22Venditti%2C+Iole%22">Venditti, Iole</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> valentina.dini@iss.it</i>
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Low-energy electrons (Auger electrons) can be produced via the interaction of photons with gold atoms in gold nanorods (AuNRs). These electrons are similar to those emitted during the decay of technetium-99m (99mTc), a radioactive nuclide widely used for diagnostics in nuclear medicine. Auger and internal conversion (IC) electron emitters appropriately targeted to the DNA of tumors cells may, therefore, represent a new radiotherapeutic approach. 99mTc radiopharmaceuticals, which are used for diagnosis, could indeed be used in theragnostic fields when loaded on AuNRs and delivered to a tumor site. This work aims to provide a proof of concept (i) to evaluate AuNRs as carriers of 99mTc-based radiopharmaceuticals, and (ii) to evaluate the efficacy of Auger electrons emitted by photon-irradiated AuNRs in inducing radio-induced damage in T98G cells, thus mimicking the effect of Auger electrons emitted during the decay of 99mTc used in clinical settings. Data are presented on AuNRs' chemical characterization (with an aspect ratio of 3.2 and Surface Plasmon Resonance bands at 520 and 680 nm) and the loading of pharmaceuticals (after 99mTc decay) on their surface. Spectroscopic characterizations, such as UV-Vis and synchrotron radiation-induced X-ray photoelectron (SR-XPS) spectroscopies, were performed to investigate the drug–AuNR interaction. Finally, preliminary radiobiological data on cell killing with AuNRs are presented. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.3390/nano13131898
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      – Code: eng
        Text: English
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        PageCount: 13
        StartPage: 1898
    Subjects:
      – SubjectFull: Auger effect
        Type: general
      – SubjectFull: Surface plasmon resonance
        Type: general
      – SubjectFull: Radioisotopes
        Type: general
      – SubjectFull: Nanorods
        Type: general
      – SubjectFull: Nuclides
        Type: general
      – SubjectFull: Radiopharmaceuticals
        Type: general
      – SubjectFull: Irradiation
        Type: general
      – SubjectFull: Synchrotron radiation
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      – SubjectFull: Radioactive decay
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      – TitleFull: Gold Nanorods as Radiopharmaceutical Carriers: Preparation and Preliminary Radiobiological In Vitro Tests.
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              Text: Jul2023
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