Recent advances in the application of deep eutectic solvents for the synthesis of Spiro heterocyclic scaffolds via multicomponent reactions.
Saved in:
| Title: | Recent advances in the application of deep eutectic solvents for the synthesis of Spiro heterocyclic scaffolds via multicomponent reactions. |
|---|---|
| Authors: | Javahershenas, Ramin1 (AUTHOR) jshbco@gmail.com |
| Source: | Journal of Molecular Liquids. Sep2023, Vol. 385, pN.PAG-N.PAG. 1p. |
| Subjects: | Eutectics, Organic chemistry, Liquid mixtures, Solvents, Spiro compounds, Organic solvents |
| Abstract: | [Display omitted] • Deep eutectic solvents (DESs) in green chemistry due to low toxicity, recoverability, and easy reusability. • Synthesizing Spiro heterocyclic scaffolds with widespread pharmacological and biological activities. • Multicomponent reactions (MCRs) are a valuable synthetic strategy. Deep eutectic solvents (DESs) consist of liquid mixtures of solid components and complexing agents as a hydrogen bond donor (eutectic combinations of Lewis or Bronsted acids and bases) at room temperature, which is a reliable, sustainable, safe, and significant alternative to conventional and common volatile and toxic solvents in green organic synthesis that have tunable physicochemical properties. The advantages of these solvents include their low toxicity, recoverability, ultra-solvent capacity, negligible flammability, easy reusability, high biodegradation, low volatile organic compound character, tunable polarity, and low flammability. As a result, these solvents have opened up a revolutionary era in green chemistry, motivating all chemists to protect the environment. In the field of organic chemistry and medicinal research, MCR has been a valuable synthetic strategy method thanks to its high yields, regioselectivity, and short reaction times. Over the last decade, Spiro cyclic skeletons have gained widespread recognition due to their pharmacological properties as well as potential biological activities. Accordingly, this review will briefly discuss and highlight recent research progress on the synergistic effect of the combined use of MCRs and DESs for developing novel eco-friendly methodologies aimed at synthesizing various Spiro heterocyclic compounds through multicomponent reactions using deep eutectic solvents between 2015 and 2022. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Molecular Liquids is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: egs DbLabel: Engineering Source An: 164962998 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Recent advances in the application of deep eutectic solvents for the synthesis of Spiro heterocyclic scaffolds via multicomponent reactions. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Javahershenas%2C+Ramin%22">Javahershenas, Ramin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> jshbco@gmail.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Molecular+Liquids%22">Journal of Molecular Liquids</searchLink>. Sep2023, Vol. 385, pN.PAG-N.PAG. 1p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Eutectics%22">Eutectics</searchLink><br /><searchLink fieldCode="DE" term="%22Organic+chemistry%22">Organic chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Liquid+mixtures%22">Liquid mixtures</searchLink><br /><searchLink fieldCode="DE" term="%22Solvents%22">Solvents</searchLink><br /><searchLink fieldCode="DE" term="%22Spiro+compounds%22">Spiro compounds</searchLink><br /><searchLink fieldCode="DE" term="%22Organic+solvents%22">Organic solvents</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: [Display omitted] • Deep eutectic solvents (DESs) in green chemistry due to low toxicity, recoverability, and easy reusability. • Synthesizing Spiro heterocyclic scaffolds with widespread pharmacological and biological activities. • Multicomponent reactions (MCRs) are a valuable synthetic strategy. Deep eutectic solvents (DESs) consist of liquid mixtures of solid components and complexing agents as a hydrogen bond donor (eutectic combinations of Lewis or Bronsted acids and bases) at room temperature, which is a reliable, sustainable, safe, and significant alternative to conventional and common volatile and toxic solvents in green organic synthesis that have tunable physicochemical properties. The advantages of these solvents include their low toxicity, recoverability, ultra-solvent capacity, negligible flammability, easy reusability, high biodegradation, low volatile organic compound character, tunable polarity, and low flammability. As a result, these solvents have opened up a revolutionary era in green chemistry, motivating all chemists to protect the environment. In the field of organic chemistry and medicinal research, MCR has been a valuable synthetic strategy method thanks to its high yields, regioselectivity, and short reaction times. Over the last decade, Spiro cyclic skeletons have gained widespread recognition due to their pharmacological properties as well as potential biological activities. Accordingly, this review will briefly discuss and highlight recent research progress on the synergistic effect of the combined use of MCRs and DESs for developing novel eco-friendly methodologies aimed at synthesizing various Spiro heterocyclic compounds through multicomponent reactions using deep eutectic solvents between 2015 and 2022. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Molecular Liquids is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=164962998 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.molliq.2023.122398 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: N.PAG Subjects: – SubjectFull: Eutectics Type: general – SubjectFull: Organic chemistry Type: general – SubjectFull: Liquid mixtures Type: general – SubjectFull: Solvents Type: general – SubjectFull: Spiro compounds Type: general – SubjectFull: Organic solvents Type: general Titles: – TitleFull: Recent advances in the application of deep eutectic solvents for the synthesis of Spiro heterocyclic scaffolds via multicomponent reactions. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Javahershenas, Ramin IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 01677322 Numbering: – Type: volume Value: 385 Titles: – TitleFull: Journal of Molecular Liquids Type: main |
| ResultId | 1 |
