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Robust cardiac T1ρ$$ {\mathrm{T}}_{1_{\boldsymbol{\rho}}} $$ mapping at 3T using adiabatic spin‐lock preparations.

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Title: Robust cardiac T1ρ$$ {\mathrm{T}}_{1_{\boldsymbol{\rho}}} $$ mapping at 3T using adiabatic spin‐lock preparations.
Authors: Coletti, Chiara1 (AUTHOR), Fotaki, Anastasia2 (AUTHOR), Tourais, Joao1 (AUTHOR), Zhao, Yidong1 (AUTHOR), van de Steeg‐Henzen, Christal3 (AUTHOR), Akçakaya, Mehmet4 (AUTHOR), Tao, Qian1 (AUTHOR), Prieto, Claudia2,5,6 (AUTHOR), Weingärtner, Sebastian1 (AUTHOR) s.weingartner@tudelft.nl
Source: Magnetic Resonance in Medicine. Oct2023, Vol. 90 Issue 4, p1363-1379. 17p.
Subjects: Cardiovascular diseases, Myocardium
Abstract: Purpose: The aim of this study is to develop and optimize an adiabatic T1ρ$$ {\mathrm{T}}_{1\uprho} $$ (T1ρ,adiab$$ {\mathrm{T}}_{1\uprho, \mathrm{adiab}} $$) mapping method for robust quantification of spin‐lock (SL) relaxation in the myocardium at 3T. Methods: Adiabatic SL (aSL) preparations were optimized for resilience against B0$$ {\mathrm{B}}_0 $$ and B1+$$ {\mathrm{B}}_1^{+} $$ inhomogeneities using Bloch simulations. Optimized B0$$ {\mathrm{B}}_0 $$‐aSL, Bal‐aSL and B1$$ {\mathrm{B}}_1 $$‐aSL modules, each compensating for different inhomogeneities, were first validated in phantom and human calf. Myocardial T1ρ$$ {\mathrm{T}}_{1\uprho} $$ mapping was performed using a single breath‐hold cardiac‐triggered bSSFP‐based sequence. Then, optimized T1ρ,adiab$$ {\mathrm{T}}_{1\uprho, \mathrm{adiab}} $$ preparations were compared to each other and to conventional SL‐prepared T1ρ$$ {\mathrm{T}}_{1\uprho} $$ maps (RefSL) in phantoms to assess repeatability, and in 13 healthy subjects to investigate image quality, precision, reproducibility and intersubject variability. Finally, aSL and RefSL sequences were tested on six patients with known or suspected cardiovascular disease and compared with LGE, T1$$ {\mathrm{T}}_1 $$, and ECV mapping. Results: The highest T1ρ,adiab$$ {\mathrm{T}}_{1\uprho, \mathrm{adiab}} $$ preparation efficiency was obtained in simulations for modules comprising 2 HS pulses of 30 ms each. In vivo T1ρ,adiab$$ {\mathrm{T}}_{1\uprho, \mathrm{adiab}} $$ maps yielded significantly higher quality than RefSL maps. Average myocardial T1ρ,adiab$$ {\mathrm{T}}_{1\uprho, \mathrm{adiab}} $$ values were 183.28 ±$$ \pm $$ 25.53 ms, compared with 38.21 ±$$ \pm $$ 14.37 ms RefSL‐prepared T1ρ$$ {\mathrm{T}}_{1\uprho} $$. T1ρ,adiab$$ {\mathrm{T}}_{1\uprho, \mathrm{adiab}} $$ maps showed a significant improvement in precision (avg. 14.47 ±$$ \pm $$ 3.71% aSL, 37.61 ±$$ \pm $$ 19.42% RefSL, p < 0.01) and reproducibility (avg. 4.64 ±$$ \pm $$ 2.18% aSL, 47.39 ±$$ \pm $$ 12.06% RefSL, p < 0.0001), with decreased inter‐subject variability (avg. 8.76 ±$$ \pm $$ 3.65% aSL, 51.90 ±$$ \pm $$ 15.27% RefSL, p < 0.0001). Among aSL preparations, B0$$ {\mathrm{B}}_0 $$‐aSL achieved the better inter‐subject variability. In patients, B1$$ {\mathrm{B}}_1 $$‐aSL preparations showed the best artifact resilience among the adiabatic preparations. T1ρ,adiab$$ {\mathrm{T}}_{1\uprho, \mathrm{adiab}} $$ times show focal alteration colocalized with areas of hyper‐enhancement in the LGE images. Conclusion: Adiabatic preparations enable robust in vivo quantification of myocardial SL relaxation times at 3T. [ABSTRACT FROM AUTHOR]
Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Robust cardiac T1ρ$$ {\mathrm{T}}_{1_{\boldsymbol{\rho}}} $$ mapping at 3T using adiabatic spin‐lock preparations.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Coletti%2C+Chiara%22&quot;&gt;Coletti, Chiara&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Fotaki%2C+Anastasia%22&quot;&gt;Fotaki, Anastasia&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Tourais%2C+Joao%22&quot;&gt;Tourais, Joao&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zhao%2C+Yidong%22&quot;&gt;Zhao, Yidong&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22van+de+Steeg‐Henzen%2C+Christal%22&quot;&gt;van de Steeg‐Henzen, Christal&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ak&#231;akaya%2C+Mehmet%22&quot;&gt;Ak&#231;akaya, Mehmet&lt;/searchLink&gt;&lt;relatesTo&gt;4&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Tao%2C+Qian%22&quot;&gt;Tao, Qian&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Prieto%2C+Claudia%22&quot;&gt;Prieto, Claudia&lt;/searchLink&gt;&lt;relatesTo&gt;2,5,6&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Weing&#228;rtner%2C+Sebastian%22&quot;&gt;Weing&#228;rtner, Sebastian&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; s.weingartner@tudelft.nl&lt;/i&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Magnetic+Resonance+in+Medicine%22&quot;&gt;Magnetic Resonance in Medicine&lt;/searchLink&gt;. Oct2023, Vol. 90 Issue 4, p1363-1379. 17p.
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: The aim of this study is to develop and optimize an adiabatic T1ρ$$ {\mathrm{T}}_{1\uprho} $$ (T1ρ,adiab$$ {\mathrm{T}}_{1\uprho, \mathrm{adiab}} $$) mapping method for robust quantification of spin‐lock (SL) relaxation in the myocardium at 3T. Methods: Adiabatic SL (aSL) preparations were optimized for resilience against B0$$ {\mathrm{B}}_0 $$ and B1+$$ {\mathrm{B}}_1^{+} $$ inhomogeneities using Bloch simulations. Optimized B0$$ {\mathrm{B}}_0 $$‐aSL, Bal‐aSL and B1$$ {\mathrm{B}}_1 $$‐aSL modules, each compensating for different inhomogeneities, were first validated in phantom and human calf. Myocardial T1ρ$$ {\mathrm{T}}_{1\uprho} $$ mapping was performed using a single breath‐hold cardiac‐triggered bSSFP‐based sequence. Then, optimized T1ρ,adiab$$ {\mathrm{T}}_{1\uprho, \mathrm{adiab}} $$ preparations were compared to each other and to conventional SL‐prepared T1ρ$$ {\mathrm{T}}_{1\uprho} $$ maps (RefSL) in phantoms to assess repeatability, and in 13 healthy subjects to investigate image quality, precision, reproducibility and intersubject variability. Finally, aSL and RefSL sequences were tested on six patients with known or suspected cardiovascular disease and compared with LGE, T1$$ {\mathrm{T}}_1 $$, and ECV mapping. Results: The highest T1ρ,adiab$$ {\mathrm{T}}_{1\uprho, \mathrm{adiab}} $$ preparation efficiency was obtained in simulations for modules comprising 2 HS pulses of 30 ms each. In vivo T1ρ,adiab$$ {\mathrm{T}}_{1\uprho, \mathrm{adiab}} $$ maps yielded significantly higher quality than RefSL maps. Average myocardial T1ρ,adiab$$ {\mathrm{T}}_{1\uprho, \mathrm{adiab}} $$ values were 183.28 &#177;$$ \pm $$ 25.53 ms, compared with 38.21 &#177;$$ \pm $$ 14.37 ms RefSL‐prepared T1ρ$$ {\mathrm{T}}_{1\uprho} $$. T1ρ,adiab$$ {\mathrm{T}}_{1\uprho, \mathrm{adiab}} $$ maps showed a significant improvement in precision (avg. 14.47 &#177;$$ \pm $$ 3.71% aSL, 37.61 &#177;$$ \pm $$ 19.42% RefSL, p &lt; 0.01) and reproducibility (avg. 4.64 &#177;$$ \pm $$ 2.18% aSL, 47.39 &#177;$$ \pm $$ 12.06% RefSL, p &lt; 0.0001), with decreased inter‐subject variability (avg. 8.76 &#177;$$ \pm $$ 3.65% aSL, 51.90 &#177;$$ \pm $$ 15.27% RefSL, p &lt; 0.0001). Among aSL preparations, B0$$ {\mathrm{B}}_0 $$‐aSL achieved the better inter‐subject variability. In patients, B1$$ {\mathrm{B}}_1 $$‐aSL preparations showed the best artifact resilience among the adiabatic preparations. T1ρ,adiab$$ {\mathrm{T}}_{1\uprho, \mathrm{adiab}} $$ times show focal alteration colocalized with areas of hyper‐enhancement in the LGE images. Conclusion: Adiabatic preparations enable robust in vivo quantification of myocardial SL relaxation times at 3T. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: &lt;i&gt;Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1002/mrm.29713
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        Text: English
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      – SubjectFull: Myocardium
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              Text: Oct2023
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