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PET and SPECT Imaging of ALS: An Educational Review.

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Title: PET and SPECT Imaging of ALS: An Educational Review.
Authors: Jamali, Ayaan M.1 (AUTHOR), Kethamreddy, Manasa1 (AUTHOR), Burkett, Brian J.1 (AUTHOR), Port, John D.1 (AUTHOR), Pandey, Mukesh K.1 (AUTHOR), Vasdev, Neil1 (AUTHOR)
Source: Molecular Imaging. 8/19/2023, p1-20. 20p.
Subjects: Single-photon emission computed tomography, Positron emission tomography, Magnetic resonance imaging, Pathology, Amyotrophic lateral sclerosis, Cerebral circulation
Abstract: Amyotrophic lateral sclerosis (ALS) is a disease leading to progressive motor degeneration and ultimately death. It is a complex disease that can take a significantly long time to be diagnosed, as other similar pathological conditions must be ruled out for a definite diagnosis of ALS. Noninvasive imaging of ALS has shed light on disease pathology and altered biochemistry in the ALS brain. Other than magnetic resonance imaging (MRI), two types of functional imaging, positron emission tomography (PET) and single photon emission computed tomography (SPECT), have provided valuable data about what happens in the brain of ALS patients compared to healthy controls. PET imaging has revealed a specific pattern of brain metabolism through [18F]FDG, while other radiotracers have uncovered neuroinflammation, changes in neuronal density, and protein aggregation. SPECT imaging has shown a general decrease in regional cerebral blood flow (rCBF) in ALS patients. This educational review summarizes the current state of ALS imaging with various PET and SPECT radiopharmaceuticals to better understand the pathophysiology of ALS. [ABSTRACT FROM AUTHOR]
Copyright of Molecular Imaging is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: <searchLink fieldCode="JN" term="%22Molecular+Imaging%22">Molecular Imaging</searchLink>. 8/19/2023, p1-20. 20p.
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  Data: <searchLink fieldCode="DE" term="%22Single-photon+emission+computed+tomography%22">Single-photon emission computed tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Positron+emission+tomography%22">Positron emission tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Pathology%22">Pathology</searchLink><br /><searchLink fieldCode="DE" term="%22Amyotrophic+lateral+sclerosis%22">Amyotrophic lateral sclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+circulation%22">Cerebral circulation</searchLink>
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  Data: Amyotrophic lateral sclerosis (ALS) is a disease leading to progressive motor degeneration and ultimately death. It is a complex disease that can take a significantly long time to be diagnosed, as other similar pathological conditions must be ruled out for a definite diagnosis of ALS. Noninvasive imaging of ALS has shed light on disease pathology and altered biochemistry in the ALS brain. Other than magnetic resonance imaging (MRI), two types of functional imaging, positron emission tomography (PET) and single photon emission computed tomography (SPECT), have provided valuable data about what happens in the brain of ALS patients compared to healthy controls. PET imaging has revealed a specific pattern of brain metabolism through [18F]FDG, while other radiotracers have uncovered neuroinflammation, changes in neuronal density, and protein aggregation. SPECT imaging has shown a general decrease in regional cerebral blood flow (rCBF) in ALS patients. This educational review summarizes the current state of ALS imaging with various PET and SPECT radiopharmaceuticals to better understand the pathophysiology of ALS. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Molecular Imaging is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1155/2023/5864391
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        Text: English
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        Type: general
      – SubjectFull: Positron emission tomography
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      – SubjectFull: Magnetic resonance imaging
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      – SubjectFull: Amyotrophic lateral sclerosis
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      – SubjectFull: Cerebral circulation
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      – TitleFull: PET and SPECT Imaging of ALS: An Educational Review.
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              M: 08
              Text: 8/19/2023
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