Selective Activation of Retinal Ganglion Cell Subtypes Through Targeted Electrical Stimulation Parameters.
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| Title: | Selective Activation of Retinal Ganglion Cell Subtypes Through Targeted Electrical Stimulation Parameters. |
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| Authors: | Paknahad, Javad1 (AUTHOR) paknahad@usc.edu, Humayun, Mark2 (AUTHOR), Lazzi, Gianluca3 (AUTHOR) |
| Source: | IEEE Transactions on Neural Systems & Rehabilitation Engineering. 2022, Vol. 30, p350-359. 10p. |
| Subjects: | Retinal ganglion cells, Electric stimulation, Vision, Low vision, Amplitude modulation, Calcium channels |
| Abstract: | To restore vision to the low vision, epiretinal implants have been developed to electrically stimulate the healthy retinal ganglion cells (RGCs) in the degenerate retina. Given the diversity of retinal ganglion cells as well as the difference in their visual function, selective activation of RGCs subtypes can significantly improve the quality of the restored vision. Our recent results demonstrated that with the proper modulation of the current amplitude, small D1-bistratified cells with the contribution to blue/yellow color opponent pathway can be selectively activated at high frequency (200 Hz). The computational results correlated with the clinical findings revealing the blue sensation of 5/7 subjects with epiretinal implants at high frequency. Here we further explored the impacts of alterations in pulse duration and interphase gap on the response of RGCs at high frequency. We used the developed RGCs, A2-monostratified and D1-bistratified, and examined their response to a range of pulse durations (0.1-1.2 ms) and interphase gaps (0-1 ms). We found that the use of short pulse durations with no interphase gap at high frequency increases the differential response of RGCs, offering better opportunities for selective activation of D1 cells. The presence of the interphase gap has shown to reduce the overall differential response of RGCs. We also explored how the low density of calcium channels enhances the responsiveness of RGCs at high frequency. [ABSTRACT FROM AUTHOR] |
| Copyright of IEEE Transactions on Neural Systems & Rehabilitation Engineering is the property of IEEE and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 170416029 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Selective Activation of Retinal Ganglion Cell Subtypes Through Targeted Electrical Stimulation Parameters. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Paknahad%2C+Javad%22">Paknahad, Javad</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> paknahad@usc.edu</i><br /><searchLink fieldCode="AR" term="%22Humayun%2C+Mark%22">Humayun, Mark</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lazzi%2C+Gianluca%22">Lazzi, Gianluca</searchLink><relatesTo>3</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22IEEE+Transactions+on+Neural+Systems+%26+Rehabilitation+Engineering%22">IEEE Transactions on Neural Systems & Rehabilitation Engineering</searchLink>. 2022, Vol. 30, p350-359. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Retinal+ganglion+cells%22">Retinal ganglion cells</searchLink><br /><searchLink fieldCode="DE" term="%22Electric+stimulation%22">Electric stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22Vision%22">Vision</searchLink><br /><searchLink fieldCode="DE" term="%22Low+vision%22">Low vision</searchLink><br /><searchLink fieldCode="DE" term="%22Amplitude+modulation%22">Amplitude modulation</searchLink><br /><searchLink fieldCode="DE" term="%22Calcium+channels%22">Calcium channels</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: To restore vision to the low vision, epiretinal implants have been developed to electrically stimulate the healthy retinal ganglion cells (RGCs) in the degenerate retina. Given the diversity of retinal ganglion cells as well as the difference in their visual function, selective activation of RGCs subtypes can significantly improve the quality of the restored vision. Our recent results demonstrated that with the proper modulation of the current amplitude, small D1-bistratified cells with the contribution to blue/yellow color opponent pathway can be selectively activated at high frequency (200 Hz). The computational results correlated with the clinical findings revealing the blue sensation of 5/7 subjects with epiretinal implants at high frequency. Here we further explored the impacts of alterations in pulse duration and interphase gap on the response of RGCs at high frequency. We used the developed RGCs, A2-monostratified and D1-bistratified, and examined their response to a range of pulse durations (0.1-1.2 ms) and interphase gaps (0-1 ms). We found that the use of short pulse durations with no interphase gap at high frequency increases the differential response of RGCs, offering better opportunities for selective activation of D1 cells. The presence of the interphase gap has shown to reduce the overall differential response of RGCs. We also explored how the low density of calcium channels enhances the responsiveness of RGCs at high frequency. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of IEEE Transactions on Neural Systems & Rehabilitation Engineering is the property of IEEE and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1109/TNSRE.2022.3149967 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 350 Subjects: – SubjectFull: Retinal ganglion cells Type: general – SubjectFull: Electric stimulation Type: general – SubjectFull: Vision Type: general – SubjectFull: Low vision Type: general – SubjectFull: Amplitude modulation Type: general – SubjectFull: Calcium channels Type: general Titles: – TitleFull: Selective Activation of Retinal Ganglion Cell Subtypes Through Targeted Electrical Stimulation Parameters. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Paknahad, Javad – PersonEntity: Name: NameFull: Humayun, Mark – PersonEntity: Name: NameFull: Lazzi, Gianluca IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: 2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 15344320 Numbering: – Type: volume Value: 30 Titles: – TitleFull: IEEE Transactions on Neural Systems & Rehabilitation Engineering Type: main |
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