Elective nodal irradiation versus involved-field irradiation for stage II–IV cervical esophageal squamous cell carcinoma patients undergoing definitive concurrent chemoradiotherapy: a retrospective propensity study with 8-year survival outcomes.
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| Title: | Elective nodal irradiation versus involved-field irradiation for stage II–IV cervical esophageal squamous cell carcinoma patients undergoing definitive concurrent chemoradiotherapy: a retrospective propensity study with 8-year survival outcomes. |
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| Authors: | Wang, Jianing1 (AUTHOR), Wu, Yajing1 (AUTHOR), Zhang, Wei1 (AUTHOR), Chen, Yujia1 (AUTHOR), Liu, Qing1 (AUTHOR), Jing, Shaowu1 (AUTHOR), Zhang, Jiandong2 (AUTHOR), Wu, Fengpeng1 (AUTHOR), Wang, Jun1 (AUTHOR) wangjun0818@hebmu.edu.cn, Qiao, Xueying1 (AUTHOR) xueying_qiao@126.com |
| Source: | Radiation Oncology. 8/28/2023, Vol. 18 Issue 1, p1-9. 9p. |
| Subjects: | Eni SpA, Chemoradiotherapy, Squamous cell carcinoma, Survival rate, Esophageal cancer, Propensity score matching, Irradiation, Overall survival |
| Abstract: | Background: Definitive concurrent chemoradiotherapy (dCCRT) is suggested as the standard treatment for cervical esophageal squamous cell carcinoma (CESCC). This retrospective propensity study compared the 8-year survival outcomes and acute treatment toxicities of these patients treated with elective nodal irradiation (ENI) versus involved-field irradiation (IFI). Materials and methods: Patients with stage II–IV CESCC treated with dCCRT at the Fourth Hospital of Hebei Medical University between January 1, 2007 and December 31, 2020 were enrolled in the study. All the patients were restaged according to the American Joint Commission 8th edition criteria. The propensity score matching (PSM) was used to minimize the effects of treatment selection bias and potential confounding factors including sex, age, ECOG score, clinical T stage, clinical N stage, clinical TNM stage and radiation dose between the ENI group and IFI group. Survival and the prognostic factors were evaluated. Results: The 131 eligible patients underwent ENI (60 patients, 45.8%) or IFI (71 patients, 54.2%). The median follow-up time was 91.1 months (range, 23.8–182.0 months) for all the patients. The median OS, 1-, 3-, 5-, and 8-year OS rates were 44.4 months, 87.8%, 55.1%, 38.3%, and 27.2%, respectively. After PSM, there were 49 patients in each group. The median OS, 1-, 3-, 5-, and 8-year OS rates for ENI and IFI group were 32.0 months, 83.7%, 48.5%, 38.5% and 31.1% versus 45.2 months, 89.8%, 52.5%, 37.5%, 26.1%, respectively (P = 0.966; HR 0.99, 95% CI 0.61–1.61). Similar locoregional control was obtained in both groups. The tendency of leukocytopenia and neutropenia was higher in ENI than in IFI (59.2% vs. 38.8%; P = 0.068 and 30.6% vs. 14.3%; P = 0.089) at the end of dCCRT. Conclusion: Cervical esophageal squamous cell carcinoma patients undergoing definitive concurrent chemoradiotherapy has a satisfactory prognosis with organ conservation. The involved-field irradiation might be a better alternative owing to similar overall survival outcomes and local control with less toxicity of myelosuppression. [ABSTRACT FROM AUTHOR] |
| Copyright of Radiation Oncology is the property of BioMed Central and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Items | – Name: Title Label: Title Group: Ti Data: Elective nodal irradiation versus involved-field irradiation for stage II–IV cervical esophageal squamous cell carcinoma patients undergoing definitive concurrent chemoradiotherapy: a retrospective propensity study with 8-year survival outcomes. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Wang%2C+Jianing%22">Wang, Jianing</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wu%2C+Yajing%22">Wu, Yajing</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Wei%22">Zhang, Wei</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Yujia%22">Chen, Yujia</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Qing%22">Liu, Qing</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jing%2C+Shaowu%22">Jing, Shaowu</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Jiandong%22">Zhang, Jiandong</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wu%2C+Fengpeng%22">Wu, Fengpeng</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Jun%22">Wang, Jun</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> wangjun0818@hebmu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Qiao%2C+Xueying%22">Qiao, Xueying</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> xueying_qiao@126.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Radiation+Oncology%22">Radiation Oncology</searchLink>. 8/28/2023, Vol. 18 Issue 1, p1-9. 9p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Eni+SpA%22">Eni SpA</searchLink><br /><searchLink fieldCode="DE" term="%22Chemoradiotherapy%22">Chemoradiotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Squamous+cell+carcinoma%22">Squamous cell carcinoma</searchLink><br /><searchLink fieldCode="DE" term="%22Survival+rate%22">Survival rate</searchLink><br /><searchLink fieldCode="DE" term="%22Esophageal+cancer%22">Esophageal cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Propensity+score+matching%22">Propensity score matching</searchLink><br /><searchLink fieldCode="DE" term="%22Irradiation%22">Irradiation</searchLink><br /><searchLink fieldCode="DE" term="%22Overall+survival%22">Overall survival</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Definitive concurrent chemoradiotherapy (dCCRT) is suggested as the standard treatment for cervical esophageal squamous cell carcinoma (CESCC). This retrospective propensity study compared the 8-year survival outcomes and acute treatment toxicities of these patients treated with elective nodal irradiation (ENI) versus involved-field irradiation (IFI). Materials and methods: Patients with stage II–IV CESCC treated with dCCRT at the Fourth Hospital of Hebei Medical University between January 1, 2007 and December 31, 2020 were enrolled in the study. All the patients were restaged according to the American Joint Commission 8th edition criteria. The propensity score matching (PSM) was used to minimize the effects of treatment selection bias and potential confounding factors including sex, age, ECOG score, clinical T stage, clinical N stage, clinical TNM stage and radiation dose between the ENI group and IFI group. Survival and the prognostic factors were evaluated. Results: The 131 eligible patients underwent ENI (60 patients, 45.8%) or IFI (71 patients, 54.2%). The median follow-up time was 91.1 months (range, 23.8–182.0 months) for all the patients. The median OS, 1-, 3-, 5-, and 8-year OS rates were 44.4 months, 87.8%, 55.1%, 38.3%, and 27.2%, respectively. After PSM, there were 49 patients in each group. The median OS, 1-, 3-, 5-, and 8-year OS rates for ENI and IFI group were 32.0 months, 83.7%, 48.5%, 38.5% and 31.1% versus 45.2 months, 89.8%, 52.5%, 37.5%, 26.1%, respectively (P = 0.966; HR 0.99, 95% CI 0.61–1.61). Similar locoregional control was obtained in both groups. The tendency of leukocytopenia and neutropenia was higher in ENI than in IFI (59.2% vs. 38.8%; P = 0.068 and 30.6% vs. 14.3%; P = 0.089) at the end of dCCRT. Conclusion: Cervical esophageal squamous cell carcinoma patients undergoing definitive concurrent chemoradiotherapy has a satisfactory prognosis with organ conservation. The involved-field irradiation might be a better alternative owing to similar overall survival outcomes and local control with less toxicity of myelosuppression. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Radiation Oncology is the property of BioMed Central and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s13014-023-02332-2 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 1 Subjects: – SubjectFull: Eni SpA Type: general – SubjectFull: Chemoradiotherapy Type: general – SubjectFull: Squamous cell carcinoma Type: general – SubjectFull: Survival rate Type: general – SubjectFull: Esophageal cancer Type: general – SubjectFull: Propensity score matching Type: general – SubjectFull: Irradiation Type: general – SubjectFull: Overall survival Type: general Titles: – TitleFull: Elective nodal irradiation versus involved-field irradiation for stage II–IV cervical esophageal squamous cell carcinoma patients undergoing definitive concurrent chemoradiotherapy: a retrospective propensity study with 8-year survival outcomes. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Wang, Jianing – PersonEntity: Name: NameFull: Wu, Yajing – PersonEntity: Name: NameFull: Zhang, Wei – PersonEntity: Name: NameFull: Chen, Yujia – PersonEntity: Name: NameFull: Liu, Qing – PersonEntity: Name: NameFull: Jing, Shaowu – PersonEntity: Name: NameFull: Zhang, Jiandong – PersonEntity: Name: NameFull: Wu, Fengpeng – PersonEntity: Name: NameFull: Wang, Jun – PersonEntity: Name: NameFull: Qiao, Xueying IsPartOfRelationships: – BibEntity: Dates: – D: 28 M: 08 Text: 8/28/2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 1748717X Numbering: – Type: volume Value: 18 – Type: issue Value: 1 Titles: – TitleFull: Radiation Oncology Type: main |
| ResultId | 1 |
