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Aggregation of Thermoresponsive Polymethacrylates in a Dulbecco's Modified Eagle Medium and Its Salts.

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Title: Aggregation of Thermoresponsive Polymethacrylates in a Dulbecco's Modified Eagle Medium and Its Salts.
Authors: Otulakowski, Łukasz1 (AUTHOR) lotulakowski@cmpw-pan.pl, Trzebicka, Barbara1 (AUTHOR) lotulakowski@cmpw-pan.pl
Source: Polymers (20734360). Sep2023, Vol. 15 Issue 17, p3587. 16p.
Subjects: Methyl methacrylate, Polymethacrylates, Thermoresponsive polymers, Ethylene glycol, Salts, Methacrylates, Polymers, Acrylamide
Abstract: The thermal behavior and aggregation process of the poly(N-isopropyl acrylamide), poly[oligo(ethylene glycol) methyl ether methacrylate], and poly[(2-hydroxyethyl methacrylate)-co-oligo(ethylene glycol) methyl ether methacrylate] thermoresponsive polymers were studied in a commonly used Dulbecco's Modified Eagle Medium (DMEM) cell culture medium and solutions of its individual components in the same concentration as found in DMEM. All studied copolymers exhibited an unexpected transmittance profile in the DMEM. During heating above the cloud point temperature (TCP), the polymers additionally aggregated, which led to the formation of their precipitates. The behavior of the polymers was further studied to evaluate how individual salts affected the transition temperature, size (Dh), and stability of the polymer particles. Organic additives, such as amino acids and glucose, had a significantly lesser impact on the thermoresponsive aggregation of the polymers than inorganic ones. Changes to the TCP were small and the formation of precipitates was not observed. The presence of small amounts of amino acids caused a decrease in the polymer aggregate sizes. Obtained results are of utmost importance in thermoresponsive drug nanocarrier studies. [ABSTRACT FROM AUTHOR]
Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Aggregation of Thermoresponsive Polymethacrylates in a Dulbecco's Modified Eagle Medium and Its Salts.
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  Data: <searchLink fieldCode="AR" term="%22Otulakowski%2C+Łukasz%22">Otulakowski, Łukasz</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> lotulakowski@cmpw-pan.pl</i><br /><searchLink fieldCode="AR" term="%22Trzebicka%2C+Barbara%22">Trzebicka, Barbara</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> lotulakowski@cmpw-pan.pl</i>
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  Data: <searchLink fieldCode="JN" term="%22Polymers+%2820734360%29%22">Polymers (20734360)</searchLink>. Sep2023, Vol. 15 Issue 17, p3587. 16p.
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  Data: <searchLink fieldCode="DE" term="%22Methyl+methacrylate%22">Methyl methacrylate</searchLink><br /><searchLink fieldCode="DE" term="%22Polymethacrylates%22">Polymethacrylates</searchLink><br /><searchLink fieldCode="DE" term="%22Thermoresponsive+polymers%22">Thermoresponsive polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Ethylene+glycol%22">Ethylene glycol</searchLink><br /><searchLink fieldCode="DE" term="%22Salts%22">Salts</searchLink><br /><searchLink fieldCode="DE" term="%22Methacrylates%22">Methacrylates</searchLink><br /><searchLink fieldCode="DE" term="%22Polymers%22">Polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Acrylamide%22">Acrylamide</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: The thermal behavior and aggregation process of the poly(N-isopropyl acrylamide), poly[oligo(ethylene glycol) methyl ether methacrylate], and poly[(2-hydroxyethyl methacrylate)-co-oligo(ethylene glycol) methyl ether methacrylate] thermoresponsive polymers were studied in a commonly used Dulbecco's Modified Eagle Medium (DMEM) cell culture medium and solutions of its individual components in the same concentration as found in DMEM. All studied copolymers exhibited an unexpected transmittance profile in the DMEM. During heating above the cloud point temperature (TCP), the polymers additionally aggregated, which led to the formation of their precipitates. The behavior of the polymers was further studied to evaluate how individual salts affected the transition temperature, size (Dh), and stability of the polymer particles. Organic additives, such as amino acids and glucose, had a significantly lesser impact on the thermoresponsive aggregation of the polymers than inorganic ones. Changes to the TCP were small and the formation of precipitates was not observed. The presence of small amounts of amino acids caused a decrease in the polymer aggregate sizes. Obtained results are of utmost importance in thermoresponsive drug nanocarrier studies. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Group: Ab
  Data: <i>Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.3390/polym15173587
    Languages:
      – Code: eng
        Text: English
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        PageCount: 16
        StartPage: 3587
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      – SubjectFull: Methyl methacrylate
        Type: general
      – SubjectFull: Polymethacrylates
        Type: general
      – SubjectFull: Thermoresponsive polymers
        Type: general
      – SubjectFull: Ethylene glycol
        Type: general
      – SubjectFull: Salts
        Type: general
      – SubjectFull: Methacrylates
        Type: general
      – SubjectFull: Polymers
        Type: general
      – SubjectFull: Acrylamide
        Type: general
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      – TitleFull: Aggregation of Thermoresponsive Polymethacrylates in a Dulbecco's Modified Eagle Medium and Its Salts.
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            NameFull: Otulakowski, Łukasz
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            NameFull: Trzebicka, Barbara
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          Dates:
            – D: 01
              M: 09
              Text: Sep2023
              Type: published
              Y: 2023
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