3D CEST MRI with an unevenly segmented RF irradiation scheme: A feasibility study in brain tumor imaging.
Saved in:
| Title: | 3D CEST MRI with an unevenly segmented RF irradiation scheme: A feasibility study in brain tumor imaging. |
|---|---|
| Authors: | Kim, Hahnsung1,2 (AUTHOR), Park, Suhyung3,4 (AUTHOR), Hu, Ranliang2 (AUTHOR), Hoang, Kimberly B.5 (AUTHOR), Sun, Phillip Zhe1,2 (AUTHOR) pzhesun@emory.edu |
| Source: | Magnetic Resonance in Medicine. Dec2023, Vol. 90 Issue 6, p2400-2410. 11p. |
| Subjects: | Brain tumors, Brain imaging, Magnetic resonance imaging, Irradiation, Feasibility studies |
| Abstract: | Purpose: To integrate 3D CEST EPI with an unevenly segmented RF irradiation module and preliminarily demonstrate it in the clinical setting. Methods: A CEST MRI with unevenly segmented RF saturation was implemented, including a long primary RF saturation to induce the steady‐state CEST effect, maintained with repetitive short secondary RF irradiation between readouts. This configuration reduces relaxation‐induced blur artifacts during acquisition, allowing fast 3D spatial coverage. Numerical simulations were performed to select parameters such as flip angle (FA), short RF saturation duration (Ts2), and the number of readout segments. The sequence was validated experimentally with data from a phantom, healthy volunteers, and a brain tumor patient. Results: Based on the numerical simulation and l‐carnosine gel phantom experiment, FA, Ts2, and the number of segments were set to 20°, 0.3 s, and the range from 4 to 8, respectively. The proposed method minimized signal modulation in the human brain images in the kz direction during the acquisition and provided the blur artifacts‐free CEST contrast over the whole volume. Additionally, the CEST contrast in the tumor tissue region is higher than in the contralateral normal tissue region. Conclusions: It is feasible to implement a highly accelerated 3D EPI CEST imaging with unevenly segmented RF irradiation. [ABSTRACT FROM AUTHOR] |
| Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
|
Full text is not displayed to guests.
Login for full access.
|
|
| FullText | Links: – Type: pdflink Text: Availability: 1 |
|---|---|
| Header | DbId: egs DbLabel: Engineering Source An: 172437285 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: 3D CEST MRI with an unevenly segmented RF irradiation scheme: A feasibility study in brain tumor imaging. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kim%2C+Hahnsung%22">Kim, Hahnsung</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Park%2C+Suhyung%22">Park, Suhyung</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hu%2C+Ranliang%22">Hu, Ranliang</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hoang%2C+Kimberly+B%2E%22">Hoang, Kimberly B.</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sun%2C+Phillip+Zhe%22">Sun, Phillip Zhe</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> pzhesun@emory.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Dec2023, Vol. 90 Issue 6, p2400-2410. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Brain+tumors%22">Brain tumors</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+imaging%22">Brain imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Irradiation%22">Irradiation</searchLink><br /><searchLink fieldCode="DE" term="%22Feasibility+studies%22">Feasibility studies</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: To integrate 3D CEST EPI with an unevenly segmented RF irradiation module and preliminarily demonstrate it in the clinical setting. Methods: A CEST MRI with unevenly segmented RF saturation was implemented, including a long primary RF saturation to induce the steady‐state CEST effect, maintained with repetitive short secondary RF irradiation between readouts. This configuration reduces relaxation‐induced blur artifacts during acquisition, allowing fast 3D spatial coverage. Numerical simulations were performed to select parameters such as flip angle (FA), short RF saturation duration (Ts2), and the number of readout segments. The sequence was validated experimentally with data from a phantom, healthy volunteers, and a brain tumor patient. Results: Based on the numerical simulation and l‐carnosine gel phantom experiment, FA, Ts2, and the number of segments were set to 20°, 0.3 s, and the range from 4 to 8, respectively. The proposed method minimized signal modulation in the human brain images in the kz direction during the acquisition and provided the blur artifacts‐free CEST contrast over the whole volume. Additionally, the CEST contrast in the tumor tissue region is higher than in the contralateral normal tissue region. Conclusions: It is feasible to implement a highly accelerated 3D EPI CEST imaging with unevenly segmented RF irradiation. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=172437285 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mrm.29810 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 2400 Subjects: – SubjectFull: Brain tumors Type: general – SubjectFull: Brain imaging Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Irradiation Type: general – SubjectFull: Feasibility studies Type: general Titles: – TitleFull: 3D CEST MRI with an unevenly segmented RF irradiation scheme: A feasibility study in brain tumor imaging. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kim, Hahnsung – PersonEntity: Name: NameFull: Park, Suhyung – PersonEntity: Name: NameFull: Hu, Ranliang – PersonEntity: Name: NameFull: Hoang, Kimberly B. – PersonEntity: Name: NameFull: Sun, Phillip Zhe IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 07403194 Numbering: – Type: volume Value: 90 – Type: issue Value: 6 Titles: – TitleFull: Magnetic Resonance in Medicine Type: main |
| ResultId | 1 |
