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Preparation of acid-responsive antibubbles from CaCO3-based Pickering emulsions.

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Title: Preparation of acid-responsive antibubbles from CaCO3-based Pickering emulsions.
Authors: Zia, Rabia1 (AUTHOR), Poortinga, Albert T.2 (AUTHOR), Nazir, Akmal1,3 (AUTHOR) akmal.nazir@uaeu.ac.ae, Ayyash, Mutamed3 (AUTHOR), van Nostrum, Cornelus F.1 (AUTHOR) C.F.vanNostrum@uu.nl
Source: Journal of Colloid & Interface Science. Dec2023:Part B, Vol. 652, p2054-2065. 12p.
Subjects: Stearic acid, Silica nanoparticles, Methylene blue, Emulsions, Bubbles, Calcium carbonate, Silica fume, Mesoporous silica
Abstract: [Display omitted] Hypothesis: Hydrophobized fumed silica particles were previously reported for producing antibubbles that are quite stable in neutral as well as in acidic media. To produce acid-responsive antibubbles (e.g., for gastric drug delivery), the silica nanoparticles must be replaced by suitable particles, e.g., calcium carbonate (CaCO 3), which can degrade at low pH to release the encapsulated drug. Experiments: Two variants of CaCO 3 -stabilized antibubbles were prepared (by using CaCO 3 particles pre-coated with stearic acid, or by using native CaCO 3 particles in combination with sodium stearoyl lactylate) and drug release was compared with classic antibubbles produced with hydrophobized fumed silica particles. Findings: CaCO 3 particles (pre-coated with stearic acid) can be used to produce stable antibubbles, which provided an entrapment efficiency of a model drug (methylene blue, MB) of around 85%. A burst release of MB (∼60%) from the antibubbles was observed at pH 2 (i.e., the pH of the stomach), which was further increased to 80% during the next 30 min. On the contrary, at neutral pH, about 70% of the drug remained encapsulated for at least 2 h. We further demonstrated that the acidic conditions led to the desorption of CaCO 3 particles from the air–liquid interface resulting in the destabilization of the antibubbles and the release of drug-containing cores. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Colloid & Interface Science is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 172775356
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PubTypeId: academicJournal
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  Label: Title
  Group: Ti
  Data: Preparation of acid-responsive antibubbles from CaCO3-based Pickering emulsions.
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  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22Zia%2C+Rabia%22">Zia, Rabia</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Poortinga%2C+Albert+T%2E%22">Poortinga, Albert T.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nazir%2C+Akmal%22">Nazir, Akmal</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> akmal.nazir@uaeu.ac.ae</i><br /><searchLink fieldCode="AR" term="%22Ayyash%2C+Mutamed%22">Ayyash, Mutamed</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22van+Nostrum%2C+Cornelus+F%2E%22">van Nostrum, Cornelus F.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> C.F.vanNostrum@uu.nl</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Colloid+%26+Interface+Science%22">Journal of Colloid & Interface Science</searchLink>. Dec2023:Part B, Vol. 652, p2054-2065. 12p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Stearic+acid%22">Stearic acid</searchLink><br /><searchLink fieldCode="DE" term="%22Silica+nanoparticles%22">Silica nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Methylene+blue%22">Methylene blue</searchLink><br /><searchLink fieldCode="DE" term="%22Emulsions%22">Emulsions</searchLink><br /><searchLink fieldCode="DE" term="%22Bubbles%22">Bubbles</searchLink><br /><searchLink fieldCode="DE" term="%22Calcium+carbonate%22">Calcium carbonate</searchLink><br /><searchLink fieldCode="DE" term="%22Silica+fume%22">Silica fume</searchLink><br /><searchLink fieldCode="DE" term="%22Mesoporous+silica%22">Mesoporous silica</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: [Display omitted] Hypothesis: Hydrophobized fumed silica particles were previously reported for producing antibubbles that are quite stable in neutral as well as in acidic media. To produce acid-responsive antibubbles (e.g., for gastric drug delivery), the silica nanoparticles must be replaced by suitable particles, e.g., calcium carbonate (CaCO 3), which can degrade at low pH to release the encapsulated drug. Experiments: Two variants of CaCO 3 -stabilized antibubbles were prepared (by using CaCO 3 particles pre-coated with stearic acid, or by using native CaCO 3 particles in combination with sodium stearoyl lactylate) and drug release was compared with classic antibubbles produced with hydrophobized fumed silica particles. Findings: CaCO 3 particles (pre-coated with stearic acid) can be used to produce stable antibubbles, which provided an entrapment efficiency of a model drug (methylene blue, MB) of around 85%. A burst release of MB (∼60%) from the antibubbles was observed at pH 2 (i.e., the pH of the stomach), which was further increased to 80% during the next 30 min. On the contrary, at neutral pH, about 70% of the drug remained encapsulated for at least 2 h. We further demonstrated that the acidic conditions led to the desorption of CaCO 3 particles from the air–liquid interface resulting in the destabilization of the antibubbles and the release of drug-containing cores. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Colloid & Interface Science is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.jcis.2023.09.007
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 12
        StartPage: 2054
    Subjects:
      – SubjectFull: Stearic acid
        Type: general
      – SubjectFull: Silica nanoparticles
        Type: general
      – SubjectFull: Methylene blue
        Type: general
      – SubjectFull: Emulsions
        Type: general
      – SubjectFull: Bubbles
        Type: general
      – SubjectFull: Calcium carbonate
        Type: general
      – SubjectFull: Silica fume
        Type: general
      – SubjectFull: Mesoporous silica
        Type: general
    Titles:
      – TitleFull: Preparation of acid-responsive antibubbles from CaCO3-based Pickering emulsions.
        Type: main
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      – PersonEntity:
          Name:
            NameFull: Zia, Rabia
      – PersonEntity:
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            NameFull: Poortinga, Albert T.
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            NameFull: Nazir, Akmal
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            NameFull: Ayyash, Mutamed
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            NameFull: van Nostrum, Cornelus F.
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          Dates:
            – D: 16
              M: 12
              Text: Dec2023:Part B
              Type: published
              Y: 2023
          Identifiers:
            – Type: issn-print
              Value: 00219797
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            – Type: volume
              Value: 652
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            – TitleFull: Journal of Colloid & Interface Science
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