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The effect of splenic vein diameter on the diagnosis of portal vein thrombosis.

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Title: The effect of splenic vein diameter on the diagnosis of portal vein thrombosis.
Authors: Xiong, Zhuxiang1,2 (AUTHOR), Yan, Yuling3 (AUTHOR), Wang, Xiaoze3 (AUTHOR), Liu, Zhan1,2 (AUTHOR), Luo, Xuefeng3 (AUTHOR), Zheng, Tinghui1,2,4 (AUTHOR) tinghuizh@scu.edu.cn
Source: Medical Physics. Oct2023, Vol. 50 Issue 10, p6614-6623. 10p.
Subjects: Mesenteric veins, Computational fluid dynamics, Veins, Hepatic portal system, Thrombosis, Diameter, Portal vein
Abstract: Background: It was still controversial that whether the increase of splenic vein (SV) diameter increased the risk of portal vein thrombosis (PVT), which was a severe disease with high mortality, in the clinic. Purposes: This study, using computational fluid dynamics method, aimed to investigate how the increase of SV diameter affects the portal vein hemodynamics under different anatomical and geometric features of the portal venous system, thus how it induced to PVT. Methods: The ideal models of the portal system, including different anatomical structures according to the location of left gastric vein (LGV) and inferior mesenteric vein (IMV), and different geometric morphological parameters models were established to carry out numerical simulation in this study. In addition, the morphological parameters of real patients were measured to verify the numerical simulation results. Results: First, the wall shear stress (WSS) and helicity intensity, which were closely related to the occurrence of thrombosis, gradually decreased with the increase of SV diameter in all models. However, the degree of decrease was bigger in following models: (1) the models with LGV and IMV linking to SV compared with them linking to PV; (2) the models with big angle of PV and SV compared with small angle. In addition, the morbidity of PVT was higher when LGV and IMV linked to SV rather than them linked to PV in the real patients. Moreover, the angle of PV and SV was also different between PVT and non‐PVT patients (125.53° ± 16.90° vs. 115.03° ± 16.10°, p = 0.01). Conclusion: Whether the increase of SV diameter will result in PVT is depended on the anatomical structure of portal system and the angle between PV and SV, this is also the reason leading to the clinical controversy that the increase of SV diameter is the risk factor of PVT. [ABSTRACT FROM AUTHOR]
Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: The effect of splenic vein diameter on the diagnosis of portal vein thrombosis.
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  Data: <searchLink fieldCode="AR" term="%22Xiong%2C+Zhuxiang%22">Xiong, Zhuxiang</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yan%2C+Yuling%22">Yan, Yuling</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Xiaoze%22">Wang, Xiaoze</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Zhan%22">Liu, Zhan</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Luo%2C+Xuefeng%22">Luo, Xuefeng</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zheng%2C+Tinghui%22">Zheng, Tinghui</searchLink><relatesTo>1,2,4</relatesTo> (AUTHOR)<i> tinghuizh@scu.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Medical+Physics%22">Medical Physics</searchLink>. Oct2023, Vol. 50 Issue 10, p6614-6623. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Mesenteric+veins%22">Mesenteric veins</searchLink><br /><searchLink fieldCode="DE" term="%22Computational+fluid+dynamics%22">Computational fluid dynamics</searchLink><br /><searchLink fieldCode="DE" term="%22Veins%22">Veins</searchLink><br /><searchLink fieldCode="DE" term="%22Hepatic+portal+system%22">Hepatic portal system</searchLink><br /><searchLink fieldCode="DE" term="%22Thrombosis%22">Thrombosis</searchLink><br /><searchLink fieldCode="DE" term="%22Diameter%22">Diameter</searchLink><br /><searchLink fieldCode="DE" term="%22Portal+vein%22">Portal vein</searchLink>
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  Label: Abstract
  Group: Ab
  Data: Background: It was still controversial that whether the increase of splenic vein (SV) diameter increased the risk of portal vein thrombosis (PVT), which was a severe disease with high mortality, in the clinic. Purposes: This study, using computational fluid dynamics method, aimed to investigate how the increase of SV diameter affects the portal vein hemodynamics under different anatomical and geometric features of the portal venous system, thus how it induced to PVT. Methods: The ideal models of the portal system, including different anatomical structures according to the location of left gastric vein (LGV) and inferior mesenteric vein (IMV), and different geometric morphological parameters models were established to carry out numerical simulation in this study. In addition, the morphological parameters of real patients were measured to verify the numerical simulation results. Results: First, the wall shear stress (WSS) and helicity intensity, which were closely related to the occurrence of thrombosis, gradually decreased with the increase of SV diameter in all models. However, the degree of decrease was bigger in following models: (1) the models with LGV and IMV linking to SV compared with them linking to PV; (2) the models with big angle of PV and SV compared with small angle. In addition, the morbidity of PVT was higher when LGV and IMV linked to SV rather than them linked to PV in the real patients. Moreover, the angle of PV and SV was also different between PVT and non‐PVT patients (125.53° ± 16.90° vs. 115.03° ± 16.10°, p = 0.01). Conclusion: Whether the increase of SV diameter will result in PVT is depended on the anatomical structure of portal system and the angle between PV and SV, this is also the reason leading to the clinical controversy that the increase of SV diameter is the risk factor of PVT. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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        Value: 10.1002/mp.16481
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 10
        StartPage: 6614
    Subjects:
      – SubjectFull: Mesenteric veins
        Type: general
      – SubjectFull: Computational fluid dynamics
        Type: general
      – SubjectFull: Veins
        Type: general
      – SubjectFull: Hepatic portal system
        Type: general
      – SubjectFull: Thrombosis
        Type: general
      – SubjectFull: Diameter
        Type: general
      – SubjectFull: Portal vein
        Type: general
    Titles:
      – TitleFull: The effect of splenic vein diameter on the diagnosis of portal vein thrombosis.
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            NameFull: Xiong, Zhuxiang
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            NameFull: Yan, Yuling
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              M: 10
              Text: Oct2023
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              Y: 2023
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