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Hydrogen nanobubbles: A novel approach toward radio‐sensitization agents.

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Title: Hydrogen nanobubbles: A novel approach toward radio‐sensitization agents.
Authors: Hashemi, Samaneh1 (AUTHOR), Aghamiri, Seyed Mahmoud‐Reza1 (AUTHOR), Siavashpour, Zahra2 (AUTHOR) z_siavashpour@sbmu.ac.ir, Kahani, Mahdi1 (AUTHOR), Zaidi, Habib3 (AUTHOR), Jaberi, Ramin4,5 (AUTHOR)
Source: Medical Physics. Oct2023, Vol. 50 Issue 10, p6589-6599. 11p.
Subjects: Imaging phantoms, High dose rate brachytherapy, Thermoluminescence dosimetry, Sclera, Absorbed dose, Drug dosage, Hydrogen, Radioisotope brachytherapy
Abstract: Background: Ocular melanoma is a rare kind of eye malignancy that threatens the patient's eyesight. Radiotherapy and surgical removal are the most commonly used therapeutic modalities, and nanomedicine has lately entered this field. Brachytherapy using Ruthenium‐106 (106Ru) ophthalmic plaques has been used for decades to treat ocular melanoma, with the applicator placed on the patient's eyes until the prescribed dose reaches the tumor apex. Purpose: To investigate the efficiency of hydrogen nanobubbles (H2‐NBs) employment during intraocular melanoma brachytherapy using a 106Ru electron emitter plaque. Methods: The Monte Carlo (MC) simulation and experimental investigation using a 3D‐designed phantom and thermoluminescence dosimetry (TLD) were employed. Various concentrations of H2‐NBs with a diameter of 100 nm were simulated inside tumor tissue. The results were presented as deposited energy and dose enhancement factor (DEF). An equivalent Resin phantom of the human eyeball was made using AutoCAD and 3D‐Printer technologies. The glass‐bead TLDs dosimeter were employed and placed inside the phantom. Results: Using a 1% concentration of H2‐NBs, a DEF of 93% and 98% were achieved at the tumor apex of 10 mm from the experimental setup and MC simulation, respectively. For simulated concentrations of 0.1%, 0.3%, 0.5%, 1%, and 4% H2‐NBs, a maximum dose enhancement of 154%, 174%, 188%, 200%, and 300% were achieved, respectively, and a dose reduction was seen at about 3 mm from the plaque surface. Conclusion: H2‐NBs can be used as an absorbed dose enhancer in 106Ru eye brachytherapy because of their unique physical characteristics. Reducing plaque implantation time on the patient's eye, reducing sclera absorbed dose, and decreasing the risk of patients' healthy organs irradiation are reported as some of the potential benefits of using H2‐NBs. [ABSTRACT FROM AUTHOR]
Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Hydrogen nanobubbles: A novel approach toward radio‐sensitization agents.
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  Data: <searchLink fieldCode="AR" term="%22Hashemi%2C+Samaneh%22">Hashemi, Samaneh</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Aghamiri%2C+Seyed+Mahmoud‐Reza%22">Aghamiri, Seyed Mahmoud‐Reza</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Siavashpour%2C+Zahra%22">Siavashpour, Zahra</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> z_siavashpour@sbmu.ac.ir</i><br /><searchLink fieldCode="AR" term="%22Kahani%2C+Mahdi%22">Kahani, Mahdi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zaidi%2C+Habib%22">Zaidi, Habib</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jaberi%2C+Ramin%22">Jaberi, Ramin</searchLink><relatesTo>4,5</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Medical+Physics%22">Medical Physics</searchLink>. Oct2023, Vol. 50 Issue 10, p6589-6599. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Imaging+phantoms%22">Imaging phantoms</searchLink><br /><searchLink fieldCode="DE" term="%22High+dose+rate+brachytherapy%22">High dose rate brachytherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Thermoluminescence+dosimetry%22">Thermoluminescence dosimetry</searchLink><br /><searchLink fieldCode="DE" term="%22Sclera%22">Sclera</searchLink><br /><searchLink fieldCode="DE" term="%22Absorbed+dose%22">Absorbed dose</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+dosage%22">Drug dosage</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrogen%22">Hydrogen</searchLink><br /><searchLink fieldCode="DE" term="%22Radioisotope+brachytherapy%22">Radioisotope brachytherapy</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Background: Ocular melanoma is a rare kind of eye malignancy that threatens the patient's eyesight. Radiotherapy and surgical removal are the most commonly used therapeutic modalities, and nanomedicine has lately entered this field. Brachytherapy using Ruthenium‐106 (106Ru) ophthalmic plaques has been used for decades to treat ocular melanoma, with the applicator placed on the patient's eyes until the prescribed dose reaches the tumor apex. Purpose: To investigate the efficiency of hydrogen nanobubbles (H2‐NBs) employment during intraocular melanoma brachytherapy using a 106Ru electron emitter plaque. Methods: The Monte Carlo (MC) simulation and experimental investigation using a 3D‐designed phantom and thermoluminescence dosimetry (TLD) were employed. Various concentrations of H2‐NBs with a diameter of 100 nm were simulated inside tumor tissue. The results were presented as deposited energy and dose enhancement factor (DEF). An equivalent Resin phantom of the human eyeball was made using AutoCAD and 3D‐Printer technologies. The glass‐bead TLDs dosimeter were employed and placed inside the phantom. Results: Using a 1% concentration of H2‐NBs, a DEF of 93% and 98% were achieved at the tumor apex of 10 mm from the experimental setup and MC simulation, respectively. For simulated concentrations of 0.1%, 0.3%, 0.5%, 1%, and 4% H2‐NBs, a maximum dose enhancement of 154%, 174%, 188%, 200%, and 300% were achieved, respectively, and a dose reduction was seen at about 3 mm from the plaque surface. Conclusion: H2‐NBs can be used as an absorbed dose enhancer in 106Ru eye brachytherapy because of their unique physical characteristics. Reducing plaque implantation time on the patient's eye, reducing sclera absorbed dose, and decreasing the risk of patients' healthy organs irradiation are reported as some of the potential benefits of using H2‐NBs. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/mp.16521
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      – Code: eng
        Text: English
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        PageCount: 11
        StartPage: 6589
    Subjects:
      – SubjectFull: Imaging phantoms
        Type: general
      – SubjectFull: High dose rate brachytherapy
        Type: general
      – SubjectFull: Thermoluminescence dosimetry
        Type: general
      – SubjectFull: Sclera
        Type: general
      – SubjectFull: Absorbed dose
        Type: general
      – SubjectFull: Drug dosage
        Type: general
      – SubjectFull: Hydrogen
        Type: general
      – SubjectFull: Radioisotope brachytherapy
        Type: general
    Titles:
      – TitleFull: Hydrogen nanobubbles: A novel approach toward radio‐sensitization agents.
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            NameFull: Hashemi, Samaneh
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            NameFull: Aghamiri, Seyed Mahmoud‐Reza
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            NameFull: Siavashpour, Zahra
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            NameFull: Kahani, Mahdi
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            – D: 01
              M: 10
              Text: Oct2023
              Type: published
              Y: 2023
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