The quantitative analysis of low-concentration (2%) ALA-PDT assisted with Q-switch 1064-nm Nd:YAG laser for acne vulgaris treatment.
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| Title: | The quantitative analysis of low-concentration (2%) ALA-PDT assisted with Q-switch 1064-nm Nd:YAG laser for acne vulgaris treatment. |
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| Authors: | Chen, Yu-Tsung1,2 (AUTHOR), Lin, Yun-Jhen3 (AUTHOR), Chang, Chang-Cheng3,4,5,6 (AUTHOR) changcc1975@gmail.com, Liu, Po-Heng7 (AUTHOR), Huang, Yung-Hsueh7 (AUTHOR), Shen, Jia-Wei5 (AUTHOR), Lu, Meng-En5 (AUTHOR), Chiang, Hsiu-Mei5 (AUTHOR), Lin, Bor-Shyh4 (AUTHOR) |
| Source: | Lasers in Medical Science. 10/16/2023, Vol. 38 Issue 1, p1-10. 10p. |
| Subjects: | Nd-YAG lasers, Acne, Skin imaging, Patient satisfaction, Quantitative research |
| Abstract: | Conventional 5‐aminolevulinic acid-photodynamic (ALA-PDT) therapy (10–20%) has been widely applied for moderate-to-severe acne. The aim of this study is to investigate the effects of non-ablative Q-switched 1064-nm Nd:YAG laser-assisted ALA-PDT with low concentration (2%) on the treatment of acne vulgaris. Enrolled patients were randomly assigned to 2 groups. One group received combined therapy of 2% ALA-PDT and non-ablative Q-switched 1064-nm Nd:YAG laser, and the other received only 2% ALA-PDT. Patients in each group had received 3-session treatments with 4-week intervals (week 0, 4, and 8). Sebum secretion, melanin index, erythema index, and transepidermal water loss (TEWL) were assessed at week 2, 8, 12, and 24. VISIA® skin image system score and global esthetic improvement scale (GAIS) were also evaluated. Twenty-four participants were enrolled and evenly randomized to two groups. Significant improvement in sebum secretion was noted in combined therapy group compared to the monotherapy group at week 12 (37.5% versus 16.3%), and the improvement would still be noted until week 24 (18.3% versus 17.4%). Combined group also showed more severe melanin index and erythema index after treatment. For VISIA® skin analysis, patients in combined group had better percentile ranking in porphyrins and red-light images. There were no significant differences in GAIS at the end of the follow-up between each group, whereas higher proportion of satisfaction was noted in combined group at week 2. With the assistance of laser, low concentrations (2%) of 5-ALA can provide effective phototoxic reactions in treating acne vulgaris. The satisfaction of patients is high with acceptable adverse effects. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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