Deuterium metabolic imaging for 3D mapping of glucose metabolism in humans with central nervous system lesions at 3T.
Saved in:
| Title: | Deuterium metabolic imaging for 3D mapping of glucose metabolism in humans with central nervous system lesions at 3T. |
|---|---|
| Authors: | Adamson, Philip M.1 (AUTHOR) padamson@stanford.edu, Datta, Keshav2 (AUTHOR), Watkins, Ron2 (AUTHOR), Recht, Lawrence D.3 (AUTHOR), Hurd, Ralph E.2 (AUTHOR), Spielman, Daniel M.2 (AUTHOR) |
| Source: | Magnetic Resonance in Medicine. Jan2024, Vol. 91 Issue 1, p39-50. 12p. |
| Subjects: | Central nervous system, Glucose metabolism, Deuterium, Three-dimensional imaging, Signal-to-noise ratio |
| Abstract: | Purpose: To explore the potential of 3T deuterium metabolic imaging (DMI) using a birdcage 2H radiofrequency (RF) coil in both healthy volunteers and patients with central nervous system (CNS) lesions. Methods: A modified gradient filter, home‐built 2H volume RF coil, and spherical k‐space sampling were employed in a three‐dimensional chemical shift imaging acquisition to obtain high‐quality whole‐brain metabolic images of 2H‐labeled water and glucose metabolic products. These images were acquired in a healthy volunteer and three subjects with CNS lesions of varying pathologies. Hardware and pulse sequence experiments were also conducted to improve the signal‐to‐noise ratio of DMI at 3T. Results: The ability to quantify local glucose metabolism in correspondence to anatomical landmarks across patients with varying CNS lesions is demonstrated, and increased lactate is observed in one patient with the most active disease. Conclusion: DMI offers the potential to examine metabolic activity in human subjects with CNS lesions with DMI at 3T, promising for the potential of the future clinical translation of this metabolic imaging technique. [ABSTRACT FROM AUTHOR] |
| Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
|
Full text is not displayed to guests.
Login for full access.
|
|
| FullText | Links: – Type: pdflink Text: Availability: 1 |
|---|---|
| Header | DbId: egs DbLabel: Engineering Source An: 173604464 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Deuterium metabolic imaging for 3D mapping of glucose metabolism in humans with central nervous system lesions at 3T. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Adamson%2C+Philip+M%2E%22">Adamson, Philip M.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> padamson@stanford.edu</i><br /><searchLink fieldCode="AR" term="%22Datta%2C+Keshav%22">Datta, Keshav</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Watkins%2C+Ron%22">Watkins, Ron</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Recht%2C+Lawrence+D%2E%22">Recht, Lawrence D.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hurd%2C+Ralph+E%2E%22">Hurd, Ralph E.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Spielman%2C+Daniel+M%2E%22">Spielman, Daniel M.</searchLink><relatesTo>2</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Jan2024, Vol. 91 Issue 1, p39-50. 12p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Central+nervous+system%22">Central nervous system</searchLink><br /><searchLink fieldCode="DE" term="%22Glucose+metabolism%22">Glucose metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Deuterium%22">Deuterium</searchLink><br /><searchLink fieldCode="DE" term="%22Three-dimensional+imaging%22">Three-dimensional imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Signal-to-noise+ratio%22">Signal-to-noise ratio</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: To explore the potential of 3T deuterium metabolic imaging (DMI) using a birdcage 2H radiofrequency (RF) coil in both healthy volunteers and patients with central nervous system (CNS) lesions. Methods: A modified gradient filter, home‐built 2H volume RF coil, and spherical k‐space sampling were employed in a three‐dimensional chemical shift imaging acquisition to obtain high‐quality whole‐brain metabolic images of 2H‐labeled water and glucose metabolic products. These images were acquired in a healthy volunteer and three subjects with CNS lesions of varying pathologies. Hardware and pulse sequence experiments were also conducted to improve the signal‐to‐noise ratio of DMI at 3T. Results: The ability to quantify local glucose metabolism in correspondence to anatomical landmarks across patients with varying CNS lesions is demonstrated, and increased lactate is observed in one patient with the most active disease. Conclusion: DMI offers the potential to examine metabolic activity in human subjects with CNS lesions with DMI at 3T, promising for the potential of the future clinical translation of this metabolic imaging technique. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=173604464 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mrm.29830 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 39 Subjects: – SubjectFull: Central nervous system Type: general – SubjectFull: Glucose metabolism Type: general – SubjectFull: Deuterium Type: general – SubjectFull: Three-dimensional imaging Type: general – SubjectFull: Signal-to-noise ratio Type: general Titles: – TitleFull: Deuterium metabolic imaging for 3D mapping of glucose metabolism in humans with central nervous system lesions at 3T. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Adamson, Philip M. – PersonEntity: Name: NameFull: Datta, Keshav – PersonEntity: Name: NameFull: Watkins, Ron – PersonEntity: Name: NameFull: Recht, Lawrence D. – PersonEntity: Name: NameFull: Hurd, Ralph E. – PersonEntity: Name: NameFull: Spielman, Daniel M. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 07403194 Numbering: – Type: volume Value: 91 – Type: issue Value: 1 Titles: – TitleFull: Magnetic Resonance in Medicine Type: main |
| ResultId | 1 |
