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Electrosprayed Poly-butyl-succinate microparticles for sustained release of Ciprofloxacin as an antimicrobial delivery system.

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Title: Electrosprayed Poly-butyl-succinate microparticles for sustained release of Ciprofloxacin as an antimicrobial delivery system.
Authors: Puleo, Giorgia1,2 (AUTHOR), Terracina, Francesca1 (AUTHOR), Catania, Valentina3 (AUTHOR), Sciré, Sergio1 (AUTHOR), Schillaci, Domenico1 (AUTHOR), Licciardi, Mariano1 (AUTHOR) mariano.licciardi@unipa.it
Source: Powder Technology. Jan2024, Vol. 432, pN.PAG-N.PAG. 1p.
Subjects: Ciprofloxacin, Drug delivery systems, Chronic wounds & injuries, Antibacterial agents, Bacterial diseases, Healing
Abstract: The increasingly complex treatment of bacterial infections, and its relevance in the clinical setting, requires the development of innovative strategies to improve patients' quality of life. In this context, polymeric microparticles represents a versatile drug delivery system (DDS) capable of improving the antibiotics' efficacy in the treatments, by loading drugs while modifying their release profile. In this study we aimed to produce polymeric microparticles by electrospraying using Poly-Butyl-Succinate (PBS), a biodegradable and biocompatible polyester. This versatile and easy-to-use technique enabled the incorporation of the poorly water-soluble Ciprofloxacin (CPX) into the polymer matrix. CPX is a fluoroquinolone antibiotic, inhibiting bacterial replication and effectively treating various infections. PBS is a well-known water-insoluble polymer with tuneable chemical-physical properties, also used for tissue regeneration and wound healing applications. An ex-vivo permeation study on porcine skin, serving as a model for human skin, was performed to assess potential enhancement in drug permeation. The microparticles were characterized by means of different techniques (SEM-EDX, XRD, ATR-FTIR, DSC), and their degradation rate was tested in DPBS and human plasma. Moreover, the as-produced DDS enabled the sustained release of CPX for several days, which proved effective against S. aureus and P. aeruginosa and also against a reference group of bacteria of skin microbiota often involved in pathological processes that make wounds chronic and difficult to heal. MIC and MBC assays were conducted using different culture media. Effective antibacterial activity was observed, along with inhibition of P. aeruginosa biofilm formation at sub-MIC concentrations. [Display omitted] • Electrospraying enables production of polymeric microparticles (MPs) loading drugs. • MPs improve release of Ciprofloxacin (CPX), a poorly water-soluble antibiotic. • Polybutylsuccinate (PBS) aids wound healing, degrades slowly, and holds promise as a biodegradable polymer. • Electrosprayed MPs show a long release profile of CPX over long periods of time. • MPs-PBS-CPX showed effectiveness against S. aureus , P. aeruginosa and pathogenic skin bacteria. [ABSTRACT FROM AUTHOR]
Copyright of Powder Technology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
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PubType: Academic Journal
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  Data: Electrosprayed Poly-butyl-succinate microparticles for sustained release of Ciprofloxacin as an antimicrobial delivery system.
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  Data: <searchLink fieldCode="AR" term="%22Puleo%2C+Giorgia%22">Puleo, Giorgia</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Terracina%2C+Francesca%22">Terracina, Francesca</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Catania%2C+Valentina%22">Catania, Valentina</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sciré%2C+Sergio%22">Sciré, Sergio</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schillaci%2C+Domenico%22">Schillaci, Domenico</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Licciardi%2C+Mariano%22">Licciardi, Mariano</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> mariano.licciardi@unipa.it</i>
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  Data: <searchLink fieldCode="JN" term="%22Powder+Technology%22">Powder Technology</searchLink>. Jan2024, Vol. 432, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Ciprofloxacin%22">Ciprofloxacin</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+delivery+systems%22">Drug delivery systems</searchLink><br /><searchLink fieldCode="DE" term="%22Chronic+wounds+%26+injuries%22">Chronic wounds & injuries</searchLink><br /><searchLink fieldCode="DE" term="%22Antibacterial+agents%22">Antibacterial agents</searchLink><br /><searchLink fieldCode="DE" term="%22Bacterial+diseases%22">Bacterial diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Healing%22">Healing</searchLink>
– Name: Abstract
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  Data: The increasingly complex treatment of bacterial infections, and its relevance in the clinical setting, requires the development of innovative strategies to improve patients' quality of life. In this context, polymeric microparticles represents a versatile drug delivery system (DDS) capable of improving the antibiotics' efficacy in the treatments, by loading drugs while modifying their release profile. In this study we aimed to produce polymeric microparticles by electrospraying using Poly-Butyl-Succinate (PBS), a biodegradable and biocompatible polyester. This versatile and easy-to-use technique enabled the incorporation of the poorly water-soluble Ciprofloxacin (CPX) into the polymer matrix. CPX is a fluoroquinolone antibiotic, inhibiting bacterial replication and effectively treating various infections. PBS is a well-known water-insoluble polymer with tuneable chemical-physical properties, also used for tissue regeneration and wound healing applications. An ex-vivo permeation study on porcine skin, serving as a model for human skin, was performed to assess potential enhancement in drug permeation. The microparticles were characterized by means of different techniques (SEM-EDX, XRD, ATR-FTIR, DSC), and their degradation rate was tested in DPBS and human plasma. Moreover, the as-produced DDS enabled the sustained release of CPX for several days, which proved effective against S. aureus and P. aeruginosa and also against a reference group of bacteria of skin microbiota often involved in pathological processes that make wounds chronic and difficult to heal. MIC and MBC assays were conducted using different culture media. Effective antibacterial activity was observed, along with inhibition of P. aeruginosa biofilm formation at sub-MIC concentrations. [Display omitted] • Electrospraying enables production of polymeric microparticles (MPs) loading drugs. • MPs improve release of Ciprofloxacin (CPX), a poorly water-soluble antibiotic. • Polybutylsuccinate (PBS) aids wound healing, degrades slowly, and holds promise as a biodegradable polymer. • Electrosprayed MPs show a long release profile of CPX over long periods of time. • MPs-PBS-CPX showed effectiveness against S. aureus , P. aeruginosa and pathogenic skin bacteria. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Powder Technology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.powtec.2023.119152
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Ciprofloxacin
        Type: general
      – SubjectFull: Drug delivery systems
        Type: general
      – SubjectFull: Chronic wounds & injuries
        Type: general
      – SubjectFull: Antibacterial agents
        Type: general
      – SubjectFull: Bacterial diseases
        Type: general
      – SubjectFull: Healing
        Type: general
    Titles:
      – TitleFull: Electrosprayed Poly-butyl-succinate microparticles for sustained release of Ciprofloxacin as an antimicrobial delivery system.
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            NameFull: Puleo, Giorgia
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            NameFull: Terracina, Francesca
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            NameFull: Catania, Valentina
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            NameFull: Schillaci, Domenico
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            – D: 02
              M: 01
              Text: Jan2024
              Type: published
              Y: 2024
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              Value: 432
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