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Whole knee joint mapping using a phase modulated UTE adiabatic T1ρ (PM‐UTE‐AdiabT1ρ) sequence.

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Title: Whole knee joint mapping using a phase modulated UTE adiabatic T1ρ (PM‐UTE‐AdiabT1ρ) sequence.
Authors: Ma, Yajun1 (AUTHOR) yam013@ucsd.edu, Carl, Michael2 (AUTHOR), Tang, Qingbo1,3 (AUTHOR), Moazamian, Dina1 (AUTHOR), Athertya, Jiyo S.1 (AUTHOR), Jang, Hyungseok1 (AUTHOR), Bukata, Susan V.4 (AUTHOR), Chung, Christine B.1,3 (AUTHOR), Chang, Eric Y.1,3 (AUTHOR), Du, Jiang1,3,5 (AUTHOR)
Source: Magnetic Resonance in Medicine. Mar2024, Vol. 91 Issue 3, p896-910. 15p.
Subjects: Knee joint, Posterior cruciate ligament, Anterior cruciate ligament, Patellar tendon, Phase modulation
Abstract: Purpose: To develop a 3D phase modulated UTE adiabatic T1ρ (PM‐UTE‐AdiabT1ρ) sequence for whole knee joint mapping on a clinical 3 T scanner. Methods: This new sequence includes six major features: (1) a magnetization reset module, (2) a train of adiabatic full passage pulses for spin locking, (3) a phase modulation scheme (i.e., RF cycling pair), (4) a fat saturation module, (5) a variable flip angle scheme, and (6) a 3D UTE Cones sequence for data acquisition. A simple exponential fitting was used for T1ρ quantification. Phantom studies were performed to investigate PM‐UTE‐AdiabT1ρ's sensitivity to compositional changes and reproducibility as well as its correlation with continuous wave–T1ρ measurement. The PM‐UTE‐AdiabT1ρ technique was then applied to five ex vivo and five in vivo normal knees to measure T1ρ values of femoral cartilage, meniscus, posterior cruciate ligament, anterior cruciate ligament, patellar tendon, and muscle. Results: The phantom study demonstrated PM‐UTE‐AdiabT1ρ's high sensitivity to compositional changes, its high reproducibility, and its strong linear correlation with continuous wave–T1ρ measurement. The ex vivo and in vivo knee studies demonstrated average T1ρ values of 105.6 ± 8.4 and 77.9 ± 3.9 ms for the femoral cartilage, 39.2 ± 5.1 and 30.1 ± 2.2 ms for the meniscus, 51.6 ± 5.3 and 29.2 ± 2.4 ms for the posterior cruciate ligament, 79.0 ± 9.3 and 52.0 ± 3.1 ms for the anterior cruciate ligament, 19.8 ± 4.5 and 17.0 ± 1.8 ms for the patellar tendon, and 91.1 ± 8.8 and 57.6 ± 2.8 ms for the muscle, respectively. Conclusion: The 3D PM‐UTE‐AdiabT1ρ sequence allows volumetric T1ρ assessment for both short and long T2 tissues in the knee joint on a clinical 3 T scanner. [ABSTRACT FROM AUTHOR]
Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: <searchLink fieldCode="AR" term="%22Ma%2C+Yajun%22">Ma, Yajun</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> yam013@ucsd.edu</i><br /><searchLink fieldCode="AR" term="%22Carl%2C+Michael%22">Carl, Michael</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tang%2C+Qingbo%22">Tang, Qingbo</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Moazamian%2C+Dina%22">Moazamian, Dina</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Athertya%2C+Jiyo+S%2E%22">Athertya, Jiyo S.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jang%2C+Hyungseok%22">Jang, Hyungseok</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bukata%2C+Susan+V%2E%22">Bukata, Susan V.</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chung%2C+Christine+B%2E%22">Chung, Christine B.</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chang%2C+Eric+Y%2E%22">Chang, Eric Y.</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Du%2C+Jiang%22">Du, Jiang</searchLink><relatesTo>1,3,5</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Mar2024, Vol. 91 Issue 3, p896-910. 15p.
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  Data: <searchLink fieldCode="DE" term="%22Knee+joint%22">Knee joint</searchLink><br /><searchLink fieldCode="DE" term="%22Posterior+cruciate+ligament%22">Posterior cruciate ligament</searchLink><br /><searchLink fieldCode="DE" term="%22Anterior+cruciate+ligament%22">Anterior cruciate ligament</searchLink><br /><searchLink fieldCode="DE" term="%22Patellar+tendon%22">Patellar tendon</searchLink><br /><searchLink fieldCode="DE" term="%22Phase+modulation%22">Phase modulation</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: To develop a 3D phase modulated UTE adiabatic T1ρ (PM‐UTE‐AdiabT1ρ) sequence for whole knee joint mapping on a clinical 3 T scanner. Methods: This new sequence includes six major features: (1) a magnetization reset module, (2) a train of adiabatic full passage pulses for spin locking, (3) a phase modulation scheme (i.e., RF cycling pair), (4) a fat saturation module, (5) a variable flip angle scheme, and (6) a 3D UTE Cones sequence for data acquisition. A simple exponential fitting was used for T1ρ quantification. Phantom studies were performed to investigate PM‐UTE‐AdiabT1ρ's sensitivity to compositional changes and reproducibility as well as its correlation with continuous wave–T1ρ measurement. The PM‐UTE‐AdiabT1ρ technique was then applied to five ex vivo and five in vivo normal knees to measure T1ρ values of femoral cartilage, meniscus, posterior cruciate ligament, anterior cruciate ligament, patellar tendon, and muscle. Results: The phantom study demonstrated PM‐UTE‐AdiabT1ρ's high sensitivity to compositional changes, its high reproducibility, and its strong linear correlation with continuous wave–T1ρ measurement. The ex vivo and in vivo knee studies demonstrated average T1ρ values of 105.6 ± 8.4 and 77.9 ± 3.9 ms for the femoral cartilage, 39.2 ± 5.1 and 30.1 ± 2.2 ms for the meniscus, 51.6 ± 5.3 and 29.2 ± 2.4 ms for the posterior cruciate ligament, 79.0 ± 9.3 and 52.0 ± 3.1 ms for the anterior cruciate ligament, 19.8 ± 4.5 and 17.0 ± 1.8 ms for the patellar tendon, and 91.1 ± 8.8 and 57.6 ± 2.8 ms for the muscle, respectively. Conclusion: The 3D PM‐UTE‐AdiabT1ρ sequence allows volumetric T1ρ assessment for both short and long T2 tissues in the knee joint on a clinical 3 T scanner. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1002/mrm.29871
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 15
        StartPage: 896
    Subjects:
      – SubjectFull: Knee joint
        Type: general
      – SubjectFull: Posterior cruciate ligament
        Type: general
      – SubjectFull: Anterior cruciate ligament
        Type: general
      – SubjectFull: Patellar tendon
        Type: general
      – SubjectFull: Phase modulation
        Type: general
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      – TitleFull: Whole knee joint mapping using a phase modulated UTE adiabatic T1ρ (PM‐UTE‐AdiabT1ρ) sequence.
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              Text: Mar2024
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              Y: 2024
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