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Dynamic T2* relaxometry of hyperpolarized [1‐13C]pyruvate MRI in the human brain and kidneys.

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Title: Dynamic T2* relaxometry of hyperpolarized [1‐13C]pyruvate MRI in the human brain and kidneys.
Authors: Liu, Xiaoxi1 (AUTHOR) xiaoxi.liu@ucsf.edu, Cui, Di1 (AUTHOR), Xu, Duan1 (AUTHOR), Bok, Robert1 (AUTHOR), Wang, Zhen J.1 (AUTHOR), Vigneron, Daniel B.1,2 (AUTHOR), Larson, Peder E. Z.1,2 (AUTHOR), Gordon, Jeremy W.1 (AUTHOR)
Source: Magnetic Resonance in Medicine. Mar2024, Vol. 91 Issue 3, p1030-1042. 13p.
Subjects: Pyruvates, Renal cell carcinoma, Kidneys, Gray matter (Nerve tissue), Kidney tumors
Abstract: Purpose: This study aimed to quantify T2*$$ {T}_2^{\ast } $$ for hyperpolarized [1‐13C]pyruvate and metabolites in the healthy human brain and renal cell carcinoma (RCC) patients at 3 T. Methods: Dynamic T2*$$ {T}_2^{\ast } $$ values were measured with a metabolite‐specific multi‐echo spiral sequence. The dynamic T2*$$ {T}_2^{\ast } $$ of [1‐13C]pyruvate, [1‐13C]lactate, and 13C‐bicarbonate was estimated in regions of interest in the whole brain, sinus vein, gray matter, and white matter in healthy volunteers, as well as in kidney tumors and the contralateral healthy kidneys in a separate group of RCC patients. T2*$$ {T}_2^{\ast } $$ was fit using a mono‐exponential function; and metabolism was quantified using pyruvate‐to‐lactate conversion rate maps and lactate‐to‐pyruvate ratio maps, which were compared with and without an estimated T2*$$ {T}_2^{\ast } $$ correction. Results: The T2*$$ {T}_2^{\ast } $$ of pyruvate was shown to vary during the acquisition, whereas the T2*$$ {T}_2^{\ast } $$ of lactate and bicarbonate were relatively constant through time and across the organs studied. The T2*$$ {T}_2^{\ast } $$ of lactate was similar in gray matter (29.75 ± 1.04 ms), white matter (32.89 ± 0.9 ms), healthy kidney (34.61 ± 4.07 ms), and kidney tumor (33.01 ± 2.31 ms); and the T2*$$ {T}_2^{\ast } $$ of bicarbonate was different between whole‐brain (108.17 ± 14.05 ms) and healthy kidney (58.45 ± 6.63 ms). The T2*$$ {T}_2^{\ast } $$ of pyruvate had similar trends in both brain and RCC studies, reducing from 75.56 ± 2.23 ms to 22.24 ± 1.24 ms in the brain and reducing from 122.72 ± 9.86 ms to 57.38 ± 7.65 ms in the kidneys. Conclusion: Multi‐echo dynamic imaging can quantify T2*$$ {T}_2^{\ast } $$ and metabolism in a single integrated acquisition. Clear differences were observed in the T2*$$ {T}_2^{\ast } $$ of metabolites and in their behavior throughout the timecourse. [ABSTRACT FROM AUTHOR]
Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
  Group: Ti
  Data: Dynamic T2* relaxometry of hyperpolarized [1‐<superscript>13</superscript>C]pyruvate MRI in the human brain and kidneys.
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  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22Liu%2C+Xiaoxi%22">Liu, Xiaoxi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> xiaoxi.liu@ucsf.edu</i><br /><searchLink fieldCode="AR" term="%22Cui%2C+Di%22">Cui, Di</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Duan%22">Xu, Duan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bok%2C+Robert%22">Bok, Robert</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Zhen+J%2E%22">Wang, Zhen J.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vigneron%2C+Daniel+B%2E%22">Vigneron, Daniel B.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Larson%2C+Peder+E%2E+Z%2E%22">Larson, Peder E. Z.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gordon%2C+Jeremy+W%2E%22">Gordon, Jeremy W.</searchLink><relatesTo>1</relatesTo> (AUTHOR)
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  Label: Source
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  Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Mar2024, Vol. 91 Issue 3, p1030-1042. 13p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Pyruvates%22">Pyruvates</searchLink><br /><searchLink fieldCode="DE" term="%22Renal+cell+carcinoma%22">Renal cell carcinoma</searchLink><br /><searchLink fieldCode="DE" term="%22Kidneys%22">Kidneys</searchLink><br /><searchLink fieldCode="DE" term="%22Gray+matter+%28Nerve+tissue%29%22">Gray matter (Nerve tissue)</searchLink><br /><searchLink fieldCode="DE" term="%22Kidney+tumors%22">Kidney tumors</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: This study aimed to quantify T2*$$ {T}_2^{\ast } $$ for hyperpolarized [1‐13C]pyruvate and metabolites in the healthy human brain and renal cell carcinoma (RCC) patients at 3 T. Methods: Dynamic T2*$$ {T}_2^{\ast } $$ values were measured with a metabolite‐specific multi‐echo spiral sequence. The dynamic T2*$$ {T}_2^{\ast } $$ of [1‐13C]pyruvate, [1‐13C]lactate, and 13C‐bicarbonate was estimated in regions of interest in the whole brain, sinus vein, gray matter, and white matter in healthy volunteers, as well as in kidney tumors and the contralateral healthy kidneys in a separate group of RCC patients. T2*$$ {T}_2^{\ast } $$ was fit using a mono‐exponential function; and metabolism was quantified using pyruvate‐to‐lactate conversion rate maps and lactate‐to‐pyruvate ratio maps, which were compared with and without an estimated T2*$$ {T}_2^{\ast } $$ correction. Results: The T2*$$ {T}_2^{\ast } $$ of pyruvate was shown to vary during the acquisition, whereas the T2*$$ {T}_2^{\ast } $$ of lactate and bicarbonate were relatively constant through time and across the organs studied. The T2*$$ {T}_2^{\ast } $$ of lactate was similar in gray matter (29.75 ± 1.04 ms), white matter (32.89 ± 0.9 ms), healthy kidney (34.61 ± 4.07 ms), and kidney tumor (33.01 ± 2.31 ms); and the T2*$$ {T}_2^{\ast } $$ of bicarbonate was different between whole‐brain (108.17 ± 14.05 ms) and healthy kidney (58.45 ± 6.63 ms). The T2*$$ {T}_2^{\ast } $$ of pyruvate had similar trends in both brain and RCC studies, reducing from 75.56 ± 2.23 ms to 22.24 ± 1.24 ms in the brain and reducing from 122.72 ± 9.86 ms to 57.38 ± 7.65 ms in the kidneys. Conclusion: Multi‐echo dynamic imaging can quantify T2*$$ {T}_2^{\ast } $$ and metabolism in a single integrated acquisition. Clear differences were observed in the T2*$$ {T}_2^{\ast } $$ of metabolites and in their behavior throughout the timecourse. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1002/mrm.29942
    Languages:
      – Code: eng
        Text: English
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        PageCount: 13
        StartPage: 1030
    Subjects:
      – SubjectFull: Pyruvates
        Type: general
      – SubjectFull: Renal cell carcinoma
        Type: general
      – SubjectFull: Kidneys
        Type: general
      – SubjectFull: Gray matter (Nerve tissue)
        Type: general
      – SubjectFull: Kidney tumors
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      – TitleFull: Dynamic T2* relaxometry of hyperpolarized [1‐13C]pyruvate MRI in the human brain and kidneys.
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            NameFull: Liu, Xiaoxi
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              Text: Mar2024
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              Y: 2024
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