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Long-term effects of photobiomodulation therapy on blood pressure in obese rats induced by a high-fat diet.

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Title: Long-term effects of photobiomodulation therapy on blood pressure in obese rats induced by a high-fat diet.
Authors: Oishi, Jorge Camargo1 (AUTHOR), de Moraes, Luis Henrique Oliveira1,2 (AUTHOR) luis.h.o.moraes@gmail.com, Filho, Julio Cesar Conceição1 (AUTHOR), de Moraes, Thiago Francisco1 (AUTHOR), Terroni, Barbara3 (AUTHOR), de Castro, Cynthia Aparecida1 (AUTHOR), Almeida-Lopes, Luciana4 (AUTHOR), Rodrigues, Gerson Jhonatan1 (AUTHOR)
Source: Lasers in Medical Science. 1/2/2024, Vol. 39 Issue 1, p1-8. 8p.
Subjects: Photobiomodulation therapy, High-fat diet, Blood pressure, Systolic blood pressure, Arterial diseases
Abstract: The main cardiovascular disease risk associated with obesity is hypertension. The therapeutic use of photobiomodulation therapy (PBM) is suggested for the treatment of wound healing, osteoarthritis, and arterial diseases. However, few studies have measured how red laser (at 660 nm) acts over hypertension, and any of those studies used experimental obesity model. The aim of the study was an attempt to evaluate the long-term effect of PBM on systolic blood pressure in an animal model of obesity, induced by a high-fat diet (HFD). Our results indicate that PBM carried out 3 days a week was able to prevent the increase in blood pressure (133.75 ± 4.82 mmHg, n = 8) induced by a high-fat diet (150.00 ± 4.57 mmHg, n = 8; p < 0.05), restore nitric oxide levels (control: 31.7 ± 5.5 μM, n = 8; HFD + PBM: 29.9 ± 3.7 μM, n = 8 > HFD: 22.2 ± 2.9 μM, n = 8, p < 0.05), decrease lipoperoxidation (control: 1.65 ± 0.25 nM, n = 8; HFD + PBM: 2.05 ± 0.55 nM, n = 8 < HFD: 3.20 ± 0.47 nM, n = 8; p < 0.05), and improve endothelial function (pD2 control: 7.39 ± 0.08, n = 8 > pD2 HFD + PBM: 7.15 ± 0.07, n = 8 > HFD: 6.94 ± 0.07, n = 8; p < 0.05). Our results indicate that PBM prevents the elevation of blood pressure in an obese animal model by a mechanism that involves improvement of endothelial function through an antioxidant effect. [ABSTRACT FROM AUTHOR]
Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Long-term effects of photobiomodulation therapy on blood pressure in obese rats induced by a high-fat diet.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Oishi%2C+Jorge+Camargo%22&quot;&gt;Oishi, Jorge Camargo&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22de+Moraes%2C+Luis+Henrique+Oliveira%22&quot;&gt;de Moraes, Luis Henrique Oliveira&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; luis.h.o.moraes@gmail.com&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Filho%2C+Julio+Cesar+Concei&#231;&#227;o%22&quot;&gt;Filho, Julio Cesar Concei&#231;&#227;o&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22de+Moraes%2C+Thiago+Francisco%22&quot;&gt;de Moraes, Thiago Francisco&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Terroni%2C+Barbara%22&quot;&gt;Terroni, Barbara&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22de+Castro%2C+Cynthia+Aparecida%22&quot;&gt;de Castro, Cynthia Aparecida&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Almeida-Lopes%2C+Luciana%22&quot;&gt;Almeida-Lopes, Luciana&lt;/searchLink&gt;&lt;relatesTo&gt;4&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rodrigues%2C+Gerson+Jhonatan%22&quot;&gt;Rodrigues, Gerson Jhonatan&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Lasers+in+Medical+Science%22&quot;&gt;Lasers in Medical Science&lt;/searchLink&gt;. 1/2/2024, Vol. 39 Issue 1, p1-8. 8p.
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  Label: Abstract
  Group: Ab
  Data: The main cardiovascular disease risk associated with obesity is hypertension. The therapeutic use of photobiomodulation therapy (PBM) is suggested for the treatment of wound healing, osteoarthritis, and arterial diseases. However, few studies have measured how red laser (at 660 nm) acts over hypertension, and any of those studies used experimental obesity model. The aim of the study was an attempt to evaluate the long-term effect of PBM on systolic blood pressure in an animal model of obesity, induced by a high-fat diet (HFD). Our results indicate that PBM carried out 3 days a week was able to prevent the increase in blood pressure (133.75 &#177; 4.82 mmHg, n = 8) induced by a high-fat diet (150.00 &#177; 4.57 mmHg, n = 8; p &lt; 0.05), restore nitric oxide levels (control: 31.7 &#177; 5.5 μM, n = 8; HFD + PBM: 29.9 &#177; 3.7 μM, n = 8 &gt; HFD: 22.2 &#177; 2.9 μM, n = 8, p &lt; 0.05), decrease lipoperoxidation (control: 1.65 &#177; 0.25 nM, n = 8; HFD + PBM: 2.05 &#177; 0.55 nM, n = 8 &lt; HFD: 3.20 &#177; 0.47 nM, n = 8; p &lt; 0.05), and improve endothelial function (pD2 control: 7.39 &#177; 0.08, n = 8 &gt; pD2 HFD + PBM: 7.15 &#177; 0.07, n = 8 &gt; HFD: 6.94 &#177; 0.07, n = 8; p &lt; 0.05). Our results indicate that PBM prevents the elevation of blood pressure in an obese animal model by a mechanism that involves improvement of endothelial function through an antioxidant effect. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: &lt;i&gt;Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10103-023-03950-8
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        Text: English
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      – SubjectFull: Photobiomodulation therapy
        Type: general
      – SubjectFull: High-fat diet
        Type: general
      – SubjectFull: Blood pressure
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      – SubjectFull: Systolic blood pressure
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      – SubjectFull: Arterial diseases
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              Text: 1/2/2024
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