Mucoadhesive Hybrid System of Silk Fibroin Nanoparticles and Thermosensitive In Situ Hydrogel for Amphotericin B Delivery: A Potential Option for Fungal Keratitis Treatment.
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| Title: | Mucoadhesive Hybrid System of Silk Fibroin Nanoparticles and Thermosensitive In Situ Hydrogel for Amphotericin B Delivery: A Potential Option for Fungal Keratitis Treatment. |
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| Authors: | Chomchalao, Pratthana1,2 (AUTHOR) pratthana.c@ubu.ac.th, Saelim, Nuttawut3 (AUTHOR), Lamlertthon, Supaporn4 (AUTHOR), Sisopa, Premnapa5 (AUTHOR), Tiyaboonchai, Waree1 (AUTHOR) wareet@nu.ac.th |
| Source: | Polymers (20734360). Jan2024, Vol. 16 Issue 1, p148. 17p. |
| Subjects: | Hybrid systems, Fungal keratitis, Silk fibroin, Amphotericin B, Eye drops, Biomedical adhesives, Chemical stability, Hydrogels |
| Abstract: | The purpose of this work was to investigate the feasibility of a novel ophthalmic formulation of amphotericin B-encapsulated silk fibroin nanoparticles incorporated in situ hydrogel (AmB-FNPs ISG) for fungal keratitis (FK) treatment. AmB-FNPs ISG composites were successfully developed and have shown optimized physicochemical properties for ocular drug delivery. Antifungal effects against Candida albicans and in vitro ocular irritation using corneal epithelial cells were performed to evaluate the efficacy and safety of the composite formulations. The combined system of AmB-FNPs-ISG exhibited effective antifungal activity and showed significantly less toxicity to HCE cells than commercial AmB. In vitro and ex vivo mucoadhesive tests demonstrated that the combination of silk fibroin nanoparticles with in situ hydrogels could enhance the adhesion ability of the particles on the ocular surface for more than 6 h, which would increase the ocular retention time of AmB and reduce the frequency of administration during the treatment. In addition, AmB-FNP-PEG ISG showed good physical and chemical stability under storage condition for 90 days. These findings indicate that AmB-FNP-PEG ISG has a great potential and be used in mucoadhesive AmB eye drops for FK treatment. [ABSTRACT FROM AUTHOR] |
| Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 174718485 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Mucoadhesive Hybrid System of Silk Fibroin Nanoparticles and Thermosensitive In Situ Hydrogel for Amphotericin B Delivery: A Potential Option for Fungal Keratitis Treatment. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Chomchalao%2C+Pratthana%22">Chomchalao, Pratthana</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> pratthana.c@ubu.ac.th</i><br /><searchLink fieldCode="AR" term="%22Saelim%2C+Nuttawut%22">Saelim, Nuttawut</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lamlertthon%2C+Supaporn%22">Lamlertthon, Supaporn</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sisopa%2C+Premnapa%22">Sisopa, Premnapa</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tiyaboonchai%2C+Waree%22">Tiyaboonchai, Waree</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> wareet@nu.ac.th</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Polymers+%2820734360%29%22">Polymers (20734360)</searchLink>. Jan2024, Vol. 16 Issue 1, p148. 17p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Hybrid+systems%22">Hybrid systems</searchLink><br /><searchLink fieldCode="DE" term="%22Fungal+keratitis%22">Fungal keratitis</searchLink><br /><searchLink fieldCode="DE" term="%22Silk+fibroin%22">Silk fibroin</searchLink><br /><searchLink fieldCode="DE" term="%22Amphotericin+B%22">Amphotericin B</searchLink><br /><searchLink fieldCode="DE" term="%22Eye+drops%22">Eye drops</searchLink><br /><searchLink fieldCode="DE" term="%22Biomedical+adhesives%22">Biomedical adhesives</searchLink><br /><searchLink fieldCode="DE" term="%22Chemical+stability%22">Chemical stability</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrogels%22">Hydrogels</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The purpose of this work was to investigate the feasibility of a novel ophthalmic formulation of amphotericin B-encapsulated silk fibroin nanoparticles incorporated in situ hydrogel (AmB-FNPs ISG) for fungal keratitis (FK) treatment. AmB-FNPs ISG composites were successfully developed and have shown optimized physicochemical properties for ocular drug delivery. Antifungal effects against Candida albicans and in vitro ocular irritation using corneal epithelial cells were performed to evaluate the efficacy and safety of the composite formulations. The combined system of AmB-FNPs-ISG exhibited effective antifungal activity and showed significantly less toxicity to HCE cells than commercial AmB. In vitro and ex vivo mucoadhesive tests demonstrated that the combination of silk fibroin nanoparticles with in situ hydrogels could enhance the adhesion ability of the particles on the ocular surface for more than 6 h, which would increase the ocular retention time of AmB and reduce the frequency of administration during the treatment. In addition, AmB-FNP-PEG ISG showed good physical and chemical stability under storage condition for 90 days. These findings indicate that AmB-FNP-PEG ISG has a great potential and be used in mucoadhesive AmB eye drops for FK treatment. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/polym16010148 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 17 StartPage: 148 Subjects: – SubjectFull: Hybrid systems Type: general – SubjectFull: Fungal keratitis Type: general – SubjectFull: Silk fibroin Type: general – SubjectFull: Amphotericin B Type: general – SubjectFull: Eye drops Type: general – SubjectFull: Biomedical adhesives Type: general – SubjectFull: Chemical stability Type: general – SubjectFull: Hydrogels Type: general Titles: – TitleFull: Mucoadhesive Hybrid System of Silk Fibroin Nanoparticles and Thermosensitive In Situ Hydrogel for Amphotericin B Delivery: A Potential Option for Fungal Keratitis Treatment. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Chomchalao, Pratthana – PersonEntity: Name: NameFull: Saelim, Nuttawut – PersonEntity: Name: NameFull: Lamlertthon, Supaporn – PersonEntity: Name: NameFull: Sisopa, Premnapa – PersonEntity: Name: NameFull: Tiyaboonchai, Waree IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 20734360 Numbering: – Type: volume Value: 16 – Type: issue Value: 1 Titles: – TitleFull: Polymers (20734360) Type: main |
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